Kataraktoperation und kombinierte Katarakt-/Glaukomoperation als augeninnendrucksenkende Maßnahme in Augen mit relativem anterioren Mikrophthalmus

Stürmer, Jörg; Kniestedt, Christoph; Meier, F.

doi:10.1055/s-2005-858009

Cited by 3 publications

(1 citation statement)

References 4 publications

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“…Once a vicious cycle forms, the anterior chamber will become progressively shallow, and the IOP will increase continuously [35,36]. Despite the development of surgical techniques, malignant glaucoma is still frequently reported after microphthalmic cataract surgery (incidence rate: 1.85-9.52%) [6,9,18,19,37,38] [39].…”

Section: Glaucomamentioning

confidence: 99%

Cataract Surgery in Microphthalmic Eyes

Zheng¹,

Lu²,

Lin³

et al. 2024

Loss of Vision

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Microphthalmos is a congenital ocular abnormality that mainly manifests as a significant reduction in the size of the eye and is often associated with cataracts and other eye diseases. Due to its special anatomical features, cataract surgery in microphthalmos has a higher risk of intraoperative and postoperative complications and impaired visual prognosis and is associated with reduced intraocular lens (IOL) calculation accuracy. This chapter describes the characteristics of microphthalmic cataract surgery, the incidence of complications, classic and additional surgical procedures (e.g., phacoemulsification combined with prophylactic anterior lamellar sclerostomy, laser peripheral iridotomy, anterior segment vitrectomy, piggyback IOLs), and selection of IOL calculation formula.

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Section: Glaucomamentioning

confidence: 99%

Cataract Surgery in Microphthalmic Eyes

Zheng¹,

Lu²,

Lin³

et al. 2024

Loss of Vision

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Anterior Segment Optical Coherence Tomography for Evaluation of Changes in Anterior Chamber Angle and Depth after Intraocular Lens Implantation in Eyes with Glaucoma

Dawczynski

Koenigsdoerffer

Augsten

et al. 2007

European Journal of Ophthalmology

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Novel compound heterozygous variants in LTBP2 associated with relative anterior microphthalmos

Lin,

Xu,

Miao

et al. 2024

European Journal of Ophthalmology

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Purpose Relative anterior microphthalmos (RAM) is a rare congenital defect associated with severe vision impairment that is primarily caused by genetic alterations. The purpose of this study was to identify the causative genetic variants in two Chinese families with RAM with an autosomal recessive inheritance pattern. Methods DNA samples were obtained from two probands and their family members. Targeted next-generation sequencing (NGS) was used to screen 425 genes associated with inherited eye diseases to identify possible disease-causing variants in the two patients. Sanger sequencing was subsequently used to validate the results in both families. Results The targeted NGS panel identified potentially causative novel variants of the latent transforming growth factor beta binding protein 2 ( LTBP2) gene in the two RAM families: a missense variant (c.2771C > T; p.Ala924Val) and an intronic variant (c.4582 + 9A > G) in Family A and a different missense variant (c.5239C > A; p.Arg1747Ser) and a synonymous variant (c.951G > A; p.Pro317Pro) in Family B. These four novel variants all cosegregated with the disease phenotype. Conclusion To our knowledge, this is the first study to report novel LTBP2 gene variants related to RAM. Considering the importance of LTBP2 in ocular development, we provide initial insights into the potential pathogenic mechanisms of LTBP2 in RAM.

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Kataraktoperation und kombinierte Katarakt-/Glaukomoperation als augeninnendrucksenkende Maßnahme in Augen mit relativem anterioren Mikrophthalmus

Abstract: The results show that, in eyes with RAM, cataract surgery alone or in combination with glaucoma surgery can be performed with excellent results and low complication rate if adequate precautions are taken (especially the use of hyperosmotic agents).

Cited by 3 publications

References 4 publications

Cataract Surgery in Microphthalmic Eyes

Cataract Surgery in Microphthalmic Eyes

Anterior Segment Optical Coherence Tomography for Evaluation of Changes in Anterior Chamber Angle and Depth after Intraocular Lens Implantation in Eyes with Glaucoma

Novel compound heterozygous variants in LTBP2 associated with relative anterior microphthalmos

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