Kava: A Comprehensive Review of Efficacy, Safety, and Psychopharmacology

Sarris, Jerome; LaPorte, E.; Schweitzer, Isaac

doi:10.3109/00048674.2010.522554

Cited by 127 publications

(101 citation statements)

References 67 publications

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“…The pooled analysis found Kava to be effective in reducing the HAM-A total score relative to placebo (weighted mean difference = 3.9, n = 380). Another pooled analysis of six studies found an effect size of 1.1 (Cohen's d ) in favour of Kava reducing HAM-A score over placebo [64]. Those studies not included in the pooled analysis were generally congruent with this result.…”

Section: Resultsmentioning

confidence: 75%

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Complementary Medicine, Exercise, Meditation, Diet, and Lifestyle Modification for Anxiety Disorders: A Review of Current Evidence

Sarris

Moylan

Camfield

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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Use of complementary medicines and therapies (CAM) and modification of lifestyle factors such as physical activity, exercise, and diet are being increasingly considered as potential therapeutic options for anxiety disorders. The objective of this metareview was to examine evidence across a broad range of CAM and lifestyle interventions in the treatment of anxiety disorders. In early 2012 we conducted a literature search of PubMed, Scopus, CINAHL, Web of Science, PsycInfo, and the Cochrane Library, for key studies, systematic reviews, and metaanalyses in the area. Our paper found that in respect to treatment of generalized anxiety or specific disorders, CAM evidence revealed current support for the herbal medicine Kava. One isolated study shows benefit for naturopathic medicine, whereas acupuncture, yoga, and Tai chi have tentative supportive evidence, which is hampered by overall poor methodology. The breadth of evidence does not support homeopathy for treating anxiety. Strong support exists for lifestyle modifications including adoption of moderate exercise and mindfulness meditation, whereas dietary improvement, avoidance of caffeine, alcohol, and nicotine offer encouraging preliminary data. In conclusion, certain lifestyle modifications and some CAMs may provide a beneficial role in the treatment of anxiety disorders.

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Section: Resultsmentioning

confidence: 75%

“…The most researched herbal medicine in the treatment of anxiety is Piper methysticum (Kava); a perennial plant native to various regions of the South Pacific [62]. The roots of the Kava plant are traditionally prepared as a water-based beverage for its medicinal properties and psychotropic effects [63].…”

Section: Resultsmentioning

confidence: 99%

Complementary Medicine, Exercise, Meditation, Diet, and Lifestyle Modification for Anxiety Disorders: A Review of Current Evidence

Sarris

Moylan

Camfield

et al. 2012

Evidence-Based Complementary and Alternative Medicine

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“…There is no current convincing evidence for the effectiveness of homoeopathic preparations in the treatment of patients with anxiety disorders [I (M)] (Davidson et al, 2011;Pilkington et al, 2006). Kava preparations appeared to have some beneficial effects in patients with generalised anxiety disorder but have been withdrawn in many countries due to potential hepatotoxic effects [IV] (Sarris et al, 2011a (Merom et al, 2008). In panic disorder, regular exercise is marginally superior to relaxation [I (PCT)] (Wedekind et al, 2010); but less effective than either the TCA clomipramine [I (PCT)] (Broocks et al, 1998) or group CBT [II] (Hovland et al, 2012).…”

Section: Recommendations: General Aspects Of Psychological Treatmentmentioning

confidence: 99%

Evidence-based pharmacological treatment of anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder: A revision of the 2005 guidelines from the British Association for Psychopharmacology

et al. 2014

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This revision of the 2005 British Association for Psychopharmacology guidelines for the evidence-based pharmacological treatment of anxiety disorders provides an update on key steps in diagnosis and clinical management, including recognition, acute treatment, longer-term treatment, combination treatment, and further approaches for patients who have not responded to first-line interventions. A consensus meeting involving international experts in anxiety disorders reviewed the main subject areas and considered the strength of supporting evidence and its clinical implications. The guidelines are based on available evidence, were constructed after extensive feedback from participants, and are presented as recommendations to aid clinical decision-making in primary, secondary and tertiary medical care. They may also serve as a source of information for patients, their carers, and medicines management and formulary committees.

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“…Moreover, kava has been used by Western as an alcohol replacement to reduce anxiety and give relaxation feeling and as a treatment for sleeplessness, menopausal symptoms and depression (70,73). Rhizomes and roots of kava plant were the most used parts for their psychoactive properties that include sedation, anxiolysis and relaxation (74). Accordingly, the most active constituent of kava is kavalactones or kavapyrones, which is present in high concentration in roots.…”

Section: Kava (Piper Methysticum)mentioning

confidence: 99%

Hepatotoxic Botanicals - An Evidence-based Systematic Review

Abdualmjid

Sergi

2013

J Pharm Pharm Sci

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-Purpose. Herbal medicines have been increasingly used worldwide. However, the potential harms of these herbs have been noticed most recently following hepatotoxicity with ingestion of herbal remedies. The aim of this review is to evaluate the evidence of hepatotoxic effects linked to use of herbal preparations. Method. Electronic search was performed by searching several databases: PubMed, HerbMed, Google Scholar, Scopus, Cochrane Database of Systematic Reviews and Cochrane Library using both Latin and common names of several herbs. Language was restricted to English and articles were selected for relevance reporting incidence of hepatotoxicity associated with use of herbal products in human. Results. From a total of 565 relevant reviews and articles, 254 met our inclusion criteria and were analyzed.

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Kava: A Comprehensive Review of Efficacy, Safety, and Psychopharmacology

Abstract: While current evidence supports kava for generalized anxiety, more studies are required to assess comparative efficacy and safety (on the liver, cognition, driving, and sexual effects) versus established pharmaceutical comparators.

Cited by 127 publications

References 67 publications

Complementary Medicine, Exercise, Meditation, Diet, and Lifestyle Modification for Anxiety Disorders: A Review of Current Evidence

Complementary Medicine, Exercise, Meditation, Diet, and Lifestyle Modification for Anxiety Disorders: A Review of Current Evidence

Evidence-based pharmacological treatment of anxiety disorders, post-traumatic stress disorder and obsessive-compulsive disorder: A revision of the 2005 guidelines from the British Association for Psychopharmacology

Hepatotoxic Botanicals - An Evidence-based Systematic Review

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