Kawasaki disease and acute haemolytic anaemia after two IVIG infusions

Telcharova-Mihaylovska, Albena; Stefanov, Stefan; Nikolova, Irina

doi:10.1080/13102818.2016.1159529

Cited by 2 publications

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References 28 publications

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“…Data of 107 patients diagnosed with KD over a period of 21 years (1993-2014) are presented. There have been few reports dealing with the clinical aspects of KD in Bulgaria [5,6].…”

Section: Introductionmentioning

confidence: 99%

Kawasaki disease – experience of Pediatric University Hospital, Sofia, Bulgaria, 1993–2014. Part I: clinical manifestations

Telcharova-Mihaylovska

Nikolova

Marinov

et al. 2017

Biotechnology & Biotechnological Equipment

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Kawasaki disease (KD) is a vasculitis syndrome causing coronaritis in young children. As a result of the vascular damage, coronary lesions (CL), ectasia and aneurysms form in 20%-25% of the untreated children. The assessment of KD is difficult and challenging because of the lack of specific diagnostic or laboratory criteria. This is a retrospective study of 107 patients for a period of 21 years (1993-2014). In the cohort, 30.8% of patients had CL (19.6% had coronary aneurysms and 11.2% had significant coronary dilatations). The number of CL was high compared to that reported in international studies, although 45% of children were treated by modern protocols. In an attempt to analyse the reasons for the high coronary risk, the aim of this study was to investigate the clinical aspects of the disease and to establish the diagnostic problems causing diagnosis delay, which is subsequently related to increased coronary risk. The high incidence of the observed CL was associated with the failure of recognizing the disease, delayed diagnosis and, subsequently, lack of correct treatment. The analysis of the clinical presentation indicated significant correlation of gastrointestinal syndrome with typical and atypical KD. The incidence of the gastrointestinal syndrome correlated with the typical KD symptoms (p = 0.030), suggesting that it could be considered as a further diagnostic criterion.

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“…Data of 107 patients diagnosed with KD over a period of 21 years (1993-2014) are presented. There have been few reports dealing with the clinical aspects of KD in Bulgaria [5,6].…”

Section: Introductionmentioning

confidence: 99%

Kawasaki disease – experience of Pediatric University Hospital, Sofia, Bulgaria, 1993–2014. Part I: clinical manifestations

Telcharova-Mihaylovska

Nikolova

Marinov

et al. 2017

Biotechnology & Biotechnological Equipment

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“…had a second IVIG infusion plus oral corticosteroid treatment [29]. All coronary aneurysms regressed within a year.…”

Section: Treatment Of Patients With Kawasaki Diseasementioning

confidence: 99%

Kawasaki disease – experience of Pediatric University Hospital, Sofia, Bulgaria, 1993–2014. Part II: cardiovascular manifestations and treatment

Telcharova-Mihaylovska

Nikolova

Marinov

et al. 2017

Biotechnology & Biotechnological Equipment

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Kawasaki disease (KD) is a childhood vasculitis syndrome and the coronary arteries are the main target of the vascular damage. The outcome is formation of coronary lesions (CL) that develop in 20%-25% of untreated children. KD is the leading cause of myocardial infarction in infancy. Its consequences among young people are acute coronary syndrome and susceptibility to early atherosclerosis, if the disease were to remain unrecognized. We investigated the cardiac manifestations during the acute phase of the disease, the values of the fever, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) and the therapeutic factors that created increased coronary risk in our cohort of patients. The study is retrospective . In the cohort (n = 107), 30.8% had coronary lesions, including 19.6% coronary aneurysms and 11.2% significant dilatations. We found association between myocarditis, papillary and left ventricular dysfunction in the acute phase of KD and the risk of coronary aneurysms (p < 0.001). The expressively elevated CRP levels and the persistent fever during the early subacute phase correlated significantly with coronary risk (p < 0.002). The treatment with intravenous immunoglobulin (IVIG) reduced the risk of coronary aneurysms 4.8 times (p < 0.002). A follow-up was performed in 53 children with coronary lesions during the first year of the disease. A longitudinal follow-up was performed in 38 patients. Their results indicate that cardiac monitoring is obligatory for all patients who have experienced KD.

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Kawasaki disease and acute haemolytic anaemia after two IVIG infusions

Cited by 2 publications

References 28 publications

Kawasaki disease – experience of Pediatric University Hospital, Sofia, Bulgaria, 1993–2014. Part I: clinical manifestations

Kawasaki disease – experience of Pediatric University Hospital, Sofia, Bulgaria, 1993–2014. Part I: clinical manifestations

Kawasaki disease – experience of Pediatric University Hospital, Sofia, Bulgaria, 1993–2014. Part II: cardiovascular manifestations and treatment

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