Kawasaki disease and sensorineural hearing loss: an (un)expected complication

Novo, Ana; Pinto, Susana; Prior, C.; Álvares, Sílvia; Soares, Teresa; Guedes, Margarida

doi:10.1007/s00431-011-1667-3

Cited by 25 publications

(18 citation statements)

References 11 publications

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“…We observed another kind of severe complication in this case: SNHL and vestibular loss; which is not frequently reported in the literature [56]. The presence of hearing loss during the subacute phase of KD in children is very rare, especially when accompanied by canal paresis causing vestibular hypofunction.…”

Section: Discussionmentioning

confidence: 58%

Kawasaki Disease and Labyrinthitis: An Underdiagnosed Complication

Kim

Park

et al. 2017

J Audiol Otol

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Sensorineural hearing loss (SNHL) that is seldom cited as a Kawasaki disease (KD) complication is known as an additional, potentially severe, and frequently irreversible sequel. Furthermore the vestibular functions of KD have been underestimated and it could be an important complication combined with SNHL in KD. We described a case that a 4 year-old boy who developed vestibular loss with SNHL has recovered successfully with a combined treatment.

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Section: Discussionmentioning

confidence: 58%

Kawasaki Disease and Labyrinthitis: An Underdiagnosed Complication

Kim

Park

et al. 2017

J Audiol Otol

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“…This case highlights another significant complication of Kawasaki disease: acute sensorineural hearing loss. Though infrequently reported in the literature, previous case reports have documented the development of hearing loss between 2 and 4 weeks after the onset of symptoms 9–11. Magalhaes et al 12 found sensorineural hearing loss more frequently than coronary complications in a cohort of 40 patients.…”

Section: Discussionmentioning

confidence: 95%

Kawasaki disease: always straight to the heart?

2012

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Kawasaki disease is an important differential diagnosis when evaluating prolonged fever in childhood. Although the aetiology of this vasculitic disease process remains obscure, prompt recognition and treatment significantly reduces vascular complications such as coronary artery aneurysms. Patients presenting with atypical or incomplete diagnostic features remain a challenge. Here the authors describe the atypical features of Kawasaki disease that led to profound acute hearing loss in a 6-year-old boy with complex congenital heart disease. Coronary changes were not seen on early follow-up, but the patient required bilateral hearing aids. Considering Kawasaki disease early, even in the possibly confusing context of complex congenital heart disease and atypical symptomatology, is crucial to avoid long-term sequelae.

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“…Our population included 11 children, nine of whom (81.8%) were found positive for at least two of four anti-inner ear antibodies. Adult populations diagnosed with autoimmune sensorineural hearing loss have been well described, but current pediatric data is limited to few case reports and small case series [11][12][13][14][15][16][17][18][19][20].…”

Section: Discussionmentioning

confidence: 99%

Identification of autoantibodies against inner ear antigens in a cohort of children with idiopathic sensorineural hearing loss

et al. 2013

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Immune-mediated pathogenesis has been suggested for idiopathic sensorineural hearing loss. Recent studies have investigated the relationship between idiopathic sensorineural hearing loss and autoantibodies against inner ear antigens. We conducted a prospective, observational study in a series of pediatric patients affected by idiopathic sensorineural hearing loss. Autoantibodies against inner ear (anti-Cogan peptide, anti-connexin 26, anti-DEP1/CD148 and anti-reovirus), previously described in the serum of patients with Cogan's syndrome, were detected in our population. The characteristics of children whose results were positive were also evaluated to verify if clinical data, disease progression and response to treatment could confirm an immune-mediated pathogenesis. Eleven patients were enrolled and 9 of them were positive for inner ear antibodies. Non-organ specific autoantibodies were present in 5 children out of 9. An immune-mediated condition was diagnosed in 2 cases and minor immune manifestations were found in 2 additional patients. In 5 cases hearing loss remained stable without therapy, while 4 children developed progression. Two subjects were treated with corticosteroids and methotrexate, achieving hearing improvement. Another subject showed stabilization on methotrexate. Inner ear autoantibodies can be positive in children with autoimmune sensorineural hearing loss, and in conjunction with clinical data may assist the clinician in identifying a subset amenable for immune modulation therapy. Large prospective studies are needed to investigate usefulness, diagnostic and prognostic role of these autoantibodies.

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Kawasaki disease and sensorineural hearing loss: an (un)expected complication

Abstract: Sensorineural hearing loss is an uncommonly reported complication of KD. Pediatricians should be aware of this potential complication to allow for early intervention.

Cited by 25 publications

References 11 publications

Kawasaki Disease and Labyrinthitis: An Underdiagnosed Complication

Kawasaki Disease and Labyrinthitis: An Underdiagnosed Complication

Kawasaki disease: always straight to the heart?

Identification of autoantibodies against inner ear antigens in a cohort of children with idiopathic sensorineural hearing loss

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