Kawasaki disease-associated MERS: Pathological insights from SPECT findings

Sato, Tatsuharu; Ushiroda, Yoko; Oyama, Toshifumi; Nakatomi, Akiko; Motomura, Hideki; Moriuchi, Hiroyuki

doi:10.1016/j.braindev.2011.09.015

Cited by 27 publications

(19 citation statements)

References 10 publications

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“…Actually, none of 540 patients with KD presented with encephalitis/encephalopathy [4]. As far as we know, there have been only six patients with KD complicated by MERS (Table 1) [10,11], including the present four patients, their onset ranging from March 2010 to February 2011. The number of KD patients in 2010 in Japan has been reported to be 12,755, and that over 6 years being 466 [12].…”

Section: Discussionmentioning

confidence: 89%

Kawasaki disease complicated by mild encephalopathy with a reversible splenial lesion (MERS)

Takanashi

Shirai

Sugawara

et al. 2012

Journal of the Neurological Sciences

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Section: Discussionmentioning

confidence: 89%

Kawasaki disease complicated by mild encephalopathy with a reversible splenial lesion (MERS)

Takanashi

Shirai

Sugawara

et al. 2012

Journal of the Neurological Sciences

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“…MERS types 1 and 2 have been described in Kawasaki disease, a systemic vasculitis of unknown etiology . In a case report by Sato et al, while MRI showed only focal splenial‐restricted diffusion (MERS type 1), SPECT showed more diffuse hypoperfusion in the cingulate gyri, thalami, basal ganglia, brainstem, and frontal cortices, which overlapped with MERS type 2 . Diffusion abnormalities in the hemispheres where there is low density of fibers may result in subthreshold effects, whereas fibers in the CC are tightly packed and subtle diffusion abnormalities might become apparent .…”

Section: Reversible Splenial Lesionsmentioning

confidence: 99%

Lesions in the Splenium of the Corpus Callosum on MRI in Children: A Review

Kontzialis

Soares

Huisman

2017

Journal of Neuroimaging

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A wide variety of conditions may involve the splenium of the corpus callosum on magnetic resonance imaging in children. A single cause may present with different patterns of splenial involvement, and multiple diseases may have similar imaging findings. Keeping this limitation in mind, the goal of this text is to assist in the diagnostic process of pediatric neurological diseases that are characterized by prominent involvement of the splenium of the corpus callosum on imaging. The various pathologies will be reviewed and categorized based on etiology, reversibility, and pattern of additional or associated findings. Transient splenial lesions in children are an uncommon radiologic finding of unknown etiology in a long list of conditions that may present with altered consciousness, and it usually carries a favorable prognosis. The discussion continues with the presentation of diseases inflicting irreversible damage on the splenium. Familiarity with the various causes implicated in splenial injury may assist in the formulation of differential diagnosis in the appropriate clinical setting using an easily recognizable imaging finding.

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“…Sato et al [11] reported that SPECT findings of a patient with clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is associated with KD, which showed hypoperfusion of the brain and indicated that the pathogenesis of MERS is based on cerebral hypoperfusion due to vasculitis or cerebrovascular dehydration. Ichiyama et al [17] also reported that six of twenty one children’s SPECT imaging demonstrated localized cerebral hypoperfusion without abnormal neurological findings or clinical symptoms, and the follow-up SPECT revealed no abnormalities in acute stage of KD.…”

Section: Discussionmentioning

confidence: 99%

“…All information indicated cerebral hypoperfusion. Vasculitis or cerebrovascular dehydration might be important factors [11]. …”

Section: Introductionmentioning

confidence: 99%

Association between Kawasaki Disease and Autism: A Population-Based Study in Taiwan

Kuo

Chang

et al. 2014

IJERPH

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Objective: The association between Kawasaki disease and autism has rarely been studied in Asian populations. By using a nationwide Taiwanese population-based claims database, we tested the hypothesis that Kawasaki disease may increase the risk of autism in Taiwan. Materials and Methods: Our study cohort consisted of patients who had received the diagnosis of Kawasaki disease (ICD-9-CM: 446.1) between 1997 and 2005 (N = 563). For a comparison cohort, five age- and gender-matched control patients for every patient in the study cohort were selected using random sampling (N = 2,815). All subjects were tracked for 5 years from the date of cohort entry to identify whether they had developed autism (ICD-9-CM code 299.0) or not. Cox proportional hazard regressions were then performed to evaluate 5-year autism-free survival rates. Results: The main finding of this study was that patients with Kawasaki disease seem to not be at increased risk of developing autism. Of the total patients, four patients developed autism during the 5-year follow-up period, among whom two were Kawasaki disease patients and two were in the comparison cohort. Further, the adjusted hazard ratios (AHR) (AHR: 4.81; 95% confidence interval: 0.68–34.35; P = 0.117) did not show any statistical significance between the Kawasaki disease group and the control group during the 5-year follow-up. Conclusion: Our study indicated that patients with Kawasaki disease are not at increased risk of autism.

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Kawasaki disease-associated MERS: Pathological insights from SPECT findings

Cited by 27 publications

References 10 publications

Kawasaki disease complicated by mild encephalopathy with a reversible splenial lesion (MERS)

Kawasaki disease complicated by mild encephalopathy with a reversible splenial lesion (MERS)

Lesions in the Splenium of the Corpus Callosum on MRI in Children: A Review

Association between Kawasaki Disease and Autism: A Population-Based Study in Taiwan

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