Kawasaki disease in children: Epidemiology, clinical symptoms and diagnostics of 231 cases in 10 years

Zhu, Hua; Yu, Shaofei; Bai, Yuxin; Liang, Yanyan; Su, Xuewen; Pan, Jing-ying

doi:10.3892/etm.2015.2487

Cited by 15 publications

(17 citation statements)

References 31 publications

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“…Several previous epidemiological surveys suggest the onset of incomplete KD experiences an increasing trend in China. A long‐term retrospective study from Inner Mongolia revealed that the incidence of incomplete KD increased from 10.38% in 2003 to 40.12% in 2012 28 . The earlier usage of IVIG and the enhancement of paediatricians' awareness may raise the diagnostic rate of incomplete KD to some extent 29,30 .…”

Section: Discussionmentioning

confidence: 99%

“…A long-term retrospective study from Inner Mongolia revealed that the incidence of incomplete KD increased from 10.38% in 2003 to 40.12% in 2012. 28 The earlier usage of IVIG and the enhancement of paediatricians' awareness may raise the diagnostic rate of incomplete KD to some extent. 29,30 However, the association of NCA with the clinical classification is rarely reported.…”

Section: Nca and Ivig Therapymentioning

confidence: 99%

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Clinical observation of noncoronary cardiac abnormalities in Chinese children with Kawasaki disease

Liu

Qiu

et al. 2020

Eur J Clin Investigation

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Background Kawasaki disease (KD) is an acute, self‐limited vasculitis. Coronary artery aneurysm (CAA) serves as a major contributor to the long‐term prognosis of KD. In addition, acute KD usually also leads to several kinds of noncoronary cardiac abnormalities (NCA) involving the pericardium, myocardium and endocardium. Materials and methods A total of 142 Chinese children with KD were recruited from July 2015 to April 2018. Blood samples were collected at 24 hours pre‐intravenous immunoglobulin (IVIG) therapy. Several inflammatory mediators and biomarkers for acute myocardial infarction were detected. Echocardiography and electrocardiography (ECG) were performed. Results Plasma white blood cell counts (WBC) were significantly increased in patients with IVIG‐nonresponsive KD when compared with their IVIG‐responsive counterparts. A total of 106 children (74.65%) suffered from NCA, including 8 patients (5.63%) with pericardial effusion, 23 patients (16.20%) with acute myocarditis, 101 patients (71.13%) with valvular regurgitation and 8 patients (5.63%) with abnormal ECG. No significant differences were observed in the distribution of clinical classification and the response to IVIG therapy regardless of NCA exhibited or not. Conclusions Noncoronary cardiac abnormalities is almost universal in acute KD and mainly manifests as valvular regurgitation. However, it has no influence on clinical classification and the response to IVIG therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Nca and Ivig Therapymentioning

confidence: 99%

Clinical observation of noncoronary cardiac abnormalities in Chinese children with Kawasaki disease

Liu

Qiu

et al. 2020

Eur J Clin Investigation

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“…Bunun, genetik yatkınlığı olan hastalarda, hiperimmünite ile aşı yerinde reaktivasyon sonucu olduğu düşünülmektedir 1,5,13 . Bu bulgu, özellikle atipik hastalıkta erken dönemde tanı konabilmesine yardımcı olur 64 .…”

Section: Cilt Bulgularıunclassified

Kawasaki Hastalığında Görülen Sıra Dışı Klinik Durumlar

Güvenç

Oflaz

2020

Arşiv Kaynak Tarama Dergisi

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Kawasaki disease is the most frequent reason for acquired heart diseases in developed countries. The disease may develop with many clinical pictures and the most important disease-related complication is coronary arterial aneurysm. The sooner the diagnosis is made and treatment is initiated, the lower the risk for its complications to arise. Atypical Kawasaki disease is characterized by organ and system involvement, which do not clinically meet the disease criteria, are unexpected or not frequently seen under normal circumstances. Approximately 7-10% of the patients show atypical involvement. In atypical patients, coronary arterial involvement is more frequent as a result of late diagnosis. This article presents the clinical conditions that may be seen as a result of atypical Kawasaki disease in the light of literature data.

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“…The disease usually occurs in infants and young children [1]. Although one or multiple infectious triggers are most likely, the precise etiology is still unknown.…”

Section: Introductionmentioning

confidence: 99%

Difficult diagnosis of atypical kawasaki disease in an infant younger than six months: a case report

et al. 2017

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BackgroundKawasaki disease (KD) is an acute inflammatory vasculitis of unknown origin.Case presentationWe report the case of a 5-month-old child with an atypical form of KD, characterized by undulating symptoms, who developed an aneurysm of the right coronary artery and an ectasia of the left anterior descending coronary artery.ConclusionThis case report underlines the difficulties in recognizing incomplete forms of the illness in young infants, who are at higher risk of cardiac complications.

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Kawasaki disease in children: Epidemiology, clinical symptoms and diagnostics of 231 cases in 10 years

Cited by 15 publications

References 31 publications

Clinical observation of noncoronary cardiac abnormalities in Chinese children with Kawasaki disease

Clinical observation of noncoronary cardiac abnormalities in Chinese children with Kawasaki disease

Kawasaki Hastalığında Görülen Sıra Dışı Klinik Durumlar

Difficult diagnosis of atypical kawasaki disease in an infant younger than six months: a case report

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