Kawasaki Disease in Infancy

Fuller, Martha G.

doi:10.1097/tme.0000000000000253

Cited by 9 publications

(21 citation statements)

References 13 publications

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“…KD in infants is often incomplete[ 11 ] and presents a diagnostic dilemma. [ 12 ] Infants in our cohort had significantly higher IVIg resistance and CAA. Singh et al .…”

Section: Discussionmentioning

confidence: 90%

Profile of Kawasaki disease at a tertiary care center in India

Bhattad¹,

Gupta²,

Israni³

et al. 2021

Annals of Pediatric Cardiology

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Background: Kawasaki disease (KD) is the most common cause of acquired heart disease in developed countries. KD is increasingly being reported from India; however, studies involving the large number of patients are few. Methods: All children presenting to the center from January 2017 to December 2019, diagnosed to have KD, were retrospectively included in the study. Clinical and laboratory profiles, including echocardiograms, were reviewed. Factors contributing to intravenous immunoglobulin (IVIg) refractoriness and the development of coronary artery abnormalities (CAA) were assessed. Results: A total of 39 children with KD presented to the center during the study. While 32 received initial treatment at our center, seven were referred after the initial IVIg infusion. The age range was 2 months to 11 years (mean 42.15 ± 38.51 months). More than two-thirds of the cohort was male ( n = 27/39). Mucosal involvement was the commonest clinical abnormality for the group, followed by rash. Hemoglobin was significantly lower in the group with coronary artery involvement ( P = 0.001). CAA (61.5%), incomplete KD, and atypical features were much more common in infants compared to the rest. Refractoriness to treatment was significantly more common in infants ( P = 0.029). Conclusions: A significant proportion of infants with KD had cardiac involvement. Infants were more likely to have IVIg-resistant disease.

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“…KD in infants is often incomplete[ 11 ] and presents a diagnostic dilemma. [ 12 ] Infants in our cohort had significantly higher IVIg resistance and CAA. Singh et al .…”

Section: Discussionmentioning

confidence: 90%

Profile of Kawasaki disease at a tertiary care center in India

Bhattad¹,

Gupta²,

Israni³

et al. 2021

Annals of Pediatric Cardiology

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“…13 Coronary artery involvement, as the paramount complication of KD, may lead to severe coronary artery stenosis and further cause ischemic heart disease. 14 Clinically, intravenous immunoglobulin combined with aspirin is regarded as the principal therapeutic regimen of KD. 15 With the combination of intravenous immunoglobulin (IVIG) and aspirin, the incidence of coronary artery disease in sick children was greatly reduced.…”

Section: Discussionmentioning

confidence: 99%

“… 13 Coronary artery involvement, as the paramount complication of KD, may lead to severe coronary artery stenosis and further cause ischemic heart disease. 14 …”

Section: Discussionmentioning

confidence: 99%

Observation on the clinical effect of high-dose Intravenous Immunoglobulin combined with low-dose prednisone acetate in the treatment of patients with Kawasaki Disease

Zhang¹,

Wang²,

Teng³

et al. 2021

Pak J Med Sci

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Objective: To evaluate the clinical effect of high-dose intravenous immunoglobulin (HDIVIG) single dose and pulse therapy combined with small-dose prednisone acetate in the treatment of patients with Kawasaki disease (KD). Methods: Eighty patients with KD from Baoding Children’s Hospital, China, were randomly divided into two groups: the experimental group and the control group, each with 40 cases. Patients in the experimental group were treated with HDIVIG single dose, pulse therapy combined with low-dose prednisone acetate, while patients in the control group were treated with conventional-dose immunoglobulin. Patients in both groups were treated with aspirin orally, and given symptomatic treatment including anti-inflammatory, nutritional support, correction of water and electrolyte disturbance and acid-base balance. Peripheral venous blood samples were drawn from all patients at the time of admission, Day-1, Day-7 and Day-14 after treatment, and in the basic state of getting up in the morning, and then the levels of tumor necrosis factor (TNF-a), C-reactive protein (CRP), interleukin-6 (IL-6) and other inflammatory factors were detected by enzyme-linked immunosorbent assay (ELISA). The time of body temperature falling to normal, lymph node swelling recovery, hands and feet swelling, mucosal hyperemia regression after treatment in the two groups was recorded, and the treatment effect of the two groups was comprehensively evaluated. Results: After treatment, the levels of inflammatory factors such as TNF-a, CRP, IL-6 in the experimental group were significantly lower than those in the control group, with a statistically significant difference (P<0.05). In addition, the time of body temperature falling to normal, lymph node swelling recovery, hands and feet swelling, and mucosal hyperemia regression in the experimental group was significantly shorter than that in the control group (p=0.00). The effective rate of the experimental group was 95% and that of the control group was 80%, with a statistically significant difference (p=0.04). Conclusion: HDIVIG single dose, pulse therapy combined with small-dose prednisone acetate has a favourable therapeutic effect in the treatment of patients with KD, by which the inflammatory factors can be significantly improved, clinical symptoms and weight can be quickly ameliorated, and therapeutic effect can be enhanced. doi: https://doi.org/10.12669/pjms.37.4.4023 How to cite this:Zhang H, Wang MY, Teng YN, Wang XD, Cao HT. Observation on the clinical effect of high-dose Intravenous Immunoglobulin combined with low-dose prednisone acetate in the treatment of patients with Kawasaki Disease. Pak J Med Sci. 2021;37(4):---------. doi: https://doi.org/10.12669/pjms.37.4.4023 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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“…Menina de oito anos com diagnóstico de DK. P15 25 Otimizar o tempo para o diagnóstico e o tratamento de crianças com DK.…”

Section: Publicação (P)unclassified

Assistência Hospitalar Multiprofissional À Criança Com Doença De Kawasaki

Lima¹,

Medeiros²,

Alves³

et al. 2021

Rev enferm UFPE on line.

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Objetivo: identificar e mapear a assistência hospitalar multiprofissional à saúde da criança com doença de Kawasaki (DK). Método: scoping review realizada a partir do Portal de Periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior, utilizando como fonte de coleta sete bases de dados. Foram analisados artigos, dissertações e teses produzidas por pesquisadores de língua portuguesa, inglesa e espanhola que abordassem a assistência multiprofissional à saúde da criança com DK. Utilizou-se estatística descritiva simples para análise dos dados. Resultados: a amostra final consistiu em 16 pesquisas. Os membros da equipe multiprofissional que foram citados: enfermeiro, médico, fonoaudiólogo, psicólogo, odontólogo e fisioterapeuta. O enfermeiro é um profissional que desenvolve seu trabalho na assistência direta e indireta à criança com DK. Ressaltou-se a importância de todos da equipe saberem a sintomatologia da doença, pois sendo uma enfermidade com identificação clínica, todos os assistencialistas estão envolvidos nesse processo. Conclusão: notou-se poucos estudos que descrevam as funções multidisciplinares integradas. Descritores: Síndrome de Linfonodos Mucocutâneos; Equipe de Assistência ao Paciente; Hospitais; Saúde da Criança; Criança; Enfermagem.

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Kawasaki Disease in Infancy

Cited by 9 publications

References 13 publications

Profile of Kawasaki disease at a tertiary care center in India

Profile of Kawasaki disease at a tertiary care center in India

Observation on the clinical effect of high-dose Intravenous Immunoglobulin combined with low-dose prednisone acetate in the treatment of patients with Kawasaki Disease

Assistência Hospitalar Multiprofissional À Criança Com Doença De Kawasaki

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