Kawasaki Disease in Kuwait: A Prospective Study of 41 Cases

Majeed, H. A.; Shaltout, Azza; Khuffash, Faisal A.; Othaman, Babu

doi:10.5144/0256-4947.1990.642

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…Although a lower rate was reported in Chinese population (83%) [5]. In an old report from Kuwait in 1990, 83% of 41 children with KD developed desquamation [6].…”

Section: Discussionmentioning

confidence: 88%

Severe desquamation in Kawasaki disease: Is it somehow protective?

Alqanatish

Babiker

2017

Sudan J Paed

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Kawasaki disease is a common vasculitis that typically affects children between one and five years of age. We report a 12-year-old boy who presented following a presumed diagnosis of pharyngitis associated with nondesquamating skin rash and conjunctivitis. Despite treatment with amoxicillin for seven days his fever persisted for ten days and then remitted. Two weeks later, he developed full thickness extensive desquamation of his palms and soles that mandated a visit to emergency department in our tertiary health centre. Physical examination revealed full thickness desquamation of his palms and soles with absence of erythema or swelling and he had unremarkable systemic examination. Laboratory tests showed thrombocytosis and high erythrocytes sedimentation rate. Throat culture and Anti-streptolysin-O titer were negative. Aspirin, anti-platelets dose, was initiated. Echocardiography was performed in the first visit and repeated three times later: at four weeks, six weeks and at three months of the illness revealing normal coronary arteries. Follow up complete blood count and sedimentation rate were normal after six weeks, therefore, aspirin was discontinued. Full thickness desquamation, not as it would be expected, might be somehow protective against the involvement of coronary arteries in Kawasaki disease.

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“…Although a lower rate was reported in Chinese population (83%) [5]. In an old report from Kuwait in 1990, 83% of 41 children with KD developed desquamation [6].…”

Section: Discussionmentioning

confidence: 88%

Severe desquamation in Kawasaki disease: Is it somehow protective?

Alqanatish

Babiker

2017

Sudan J Paed

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“…When Kawasaki first reported KD, he described it as a febrile illness characterized by desquamation of the fingers and toes, and 49 of 50 cases were confirmed ( 1 ). Studies performed before the 1990s reported a high desquamation incidence of approximately 90% among patients of all races ( 21 – 23 ). During the 2010s, studies reported rates between 53% and 68% ( 9 , 24 ).…”

Section: Discussionmentioning

confidence: 99%

The incidence of periungual desquamation and thrombocytosis in Kawasaki disease and the importance of systematic observation in the subacute phase

Kim,

Choi,

Kim

et al. 2024

Front. Pediatr.

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BackgroundPeriungual desquamation and thrombocytosis are characteristic of the subacute phase of Kawasaki disease (KD). However, accurate observations of periungual desquamation and thrombocytosis are lacking.MethodsThis retrospective study included patients with acute-phase KD who received treatment at seven affiliated university hospitals in Korea between 2015 and 2017. Data were extracted from an anonymized registry established by the Korean Society of Kawasaki Disease. We investigated whether the findings of patients observed according to a set protocol until the subacute stage (group I) were different from those of patients observed without the use of a protocol (group II).ResultsA total of 879 patients with KD were included in the analysis. Periungual desquamation was observed in 85% and 12.7% of patients in groups I and II, respectively. Thrombocytosis was observed in 76.7% and 44.7% of patients in groups I and II, respectively. Furthermore, compared to the initial test, the platelet counts of patients increased 100% and 67.9% in group I and II, respectively. When incomplete KD was defined only by the main symptoms during the acute stage and the diagnostic criterion of periungual desquamation during the subacute stage was excluded, the significant difference in the incidence of incomplete KD between groups I and II was no longer apparent.ConclusionPerforming regular and detailed observations has resulted in a higher incidence of periungual desquamation and thrombocytosis during the subacute phase of KD than those reported in recent studies. This indicates that until now, we have been neglecting the observation of symptoms and signs during the subacute phase. Regular monitoring during this period can also aid in differentiating suspected cases of KD and facilitate appropriate follow-up of complications.

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