Kawasaki Disease in the Time of COVID-19 and MIS-C: The International Kawasaki Disease Registry

Harahsheh, Ashraf S.; Shah, Samay; Dallaire, Frédéric; Manlhiot, Cedric; Khoury, Michael; Lee, Simon; Fabi, Marianna; Mauriello, Daniel; Tierney, Elif Seda Selamet; Sabati, Arash; Dionne, Audrey; Dahdah, Nagib; Choueiter, Nadine F.; Thacker, Deepika; Giglia, Therese M.; Truong, Dongngan T.; Jain, Supriya; Portman, Michael A.; Orr, William B.; Harris, Tyler H.; Szmuszkovicz, Jacqueline R.; Farid, Pedrom; McCrindle, Brian W.

doi:10.1016/j.cjca.2023.06.001

Cited by 8 publications

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Virus‐Induced Host Chemokine CCL2 in COVID‐19 Pathogenesis: Potential Prognostic Marker and Target of Anti‐Inflammatory Strategy

Ansari,

Ahmad,

Alam

et al. 2024

Reviews in Medical Virology

View full text Add to dashboard Cite

A wide variety of inflammatory mediators, mainly cytokines and chemokines, are induced during SARS CoV‐2 infection. Among these proinflammatory mediators, chemokines tend to play a pivotal role in virus‐mediated immunopathology. The C‐C chemokine ligand 2 (CCL2), also known as monocyte chemoattractant protein‐1 (MCP‐1) is a potent proinflammatory cytokine and strong chemoattractant of monocytes, macrophages and CD4+ T cells bearing C‐C chemokine receptor type‐2 (CCR2). Besides controlling immune cell trafficking, CCL2 is also involved in multiple pathophysiological processes including systemic hyperinflammation associated cytokine release syndrome (CRS), organ fibrosis and blood coagulation. These pathological features are commonly manifested in severe and fatal cases of COVID‐19. Given the crucial role of CCL2 in COVID‐19 pathogenesis, the CCL2:CCR2 axis may constitute a potential therapeutic target to control virus‐induced hyperinflammation and multi‐organ dysfunction. Herein we describe recent advances on elucidating the role of CCL2 in COVID‐19 pathogenesis, prognosis, and a potential target of anti‐inflammatory interventions.

show abstract

Virus‐Induced Host Chemokine CCL2 in COVID‐19 Pathogenesis: Potential Prognostic Marker and Target of Anti‐Inflammatory Strategy

Ansari,

Ahmad,

Alam

et al. 2024

Reviews in Medical Virology

View full text Add to dashboard Cite

show abstract

Multisystem Inflammatory Syndrome in Children vs Kawasaki Disease: A Never-Ending Spectrum of Phenotypes

Batu

2023

Canadian Journal of Cardiology

View full text Add to dashboard Cite

Factors Associated with Shock at Presentation in Kawasaki Disease Versus Multisystem Inflammatory Syndrome in Children Associated with COVID-19

Jain,

Harahsheh,

Lee

et al. 2024

Canadian Journal of Cardiology

View full text Add to dashboard Cite

Kawasaki Disease in the Time of COVID-19 and MIS-C: The International Kawasaki Disease Registry

Cited by 8 publications

References 43 publications

Virus‐Induced Host Chemokine CCL2 in COVID‐19 Pathogenesis: Potential Prognostic Marker and Target of Anti‐Inflammatory Strategy

Virus‐Induced Host Chemokine CCL2 in COVID‐19 Pathogenesis: Potential Prognostic Marker and Target of Anti‐Inflammatory Strategy

Multisystem Inflammatory Syndrome in Children vs Kawasaki Disease: A Never-Ending Spectrum of Phenotypes

Factors Associated with Shock at Presentation in Kawasaki Disease Versus Multisystem Inflammatory Syndrome in Children Associated with COVID-19

Contact Info

Product

Resources

About