Kawasaki disease triggered by EBV virus in a child with Familial Mediterranean Fever

Maggio, Maria Cristina; Fabiano, Carmelo; Corsello, Giovanni

doi:10.1186/s13052-019-0717-8

Cited by 12 publications

(8 citation statements)

References 20 publications

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“…Multiple infectious triggers such as adenovirus and novel coronavirus have been inconclusively associated with KD (11,12). Also, KD has been associated with Epstein-Barr virus (EBV), rotavirus, and speci c bacteria (13,14). In this regard, WHO has also developed a preliminary case de nition and case report form for MIS in children and adolescents for approaching these diseases (15).…”

Section: Discussionmentioning

confidence: 99%

COVID-19 Pandemic in the Disguise of Multi System Inflammatory Syndrome in Children: A Case Series

Dashti¹,

Ebrahimi²,

Shahriarirad³

et al. 2021

Preprint

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Although nearly a year has passed since the emerge of the SARS-CoV-2 virus, with it, a serious and novel pediatric condition called children's multisystem inflammatory syndrome (MIS-C) has subsequently emerged. In order to achieve a better understanding and management of the disease, documentation and reporting of atypical cases is justified, particularly with the growing number of children with inflammatory syndrome with clinical features simulating MIS during the ongoing COVID-19 pandemic. Based on similar reports from numerous countries with temporal relation to COVID-19 infection in the community, it is essential for general pediatricians to be on alert for such atypical presentations and early referral to tertiary care should be considered as appropriate. Here we four cases of Multisystem Inflammatory Syndrome (MIS) during the COVID-19 pandemic. Early diagnosis and treatment of patients meeting full or partial criteria for MIS are critical to preventing end-organ damage and other long-term complications, especially during times of public crisis and global health emergencies, such as the novel coronavirus pandemic.

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Section: Discussionmentioning

confidence: 99%

COVID-19 Pandemic in the Disguise of Multi System Inflammatory Syndrome in Children: A Case Series

Dashti¹,

Ebrahimi²,

Shahriarirad³

et al. 2021

Preprint

View full text Add to dashboard Cite

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“…41 A prospective study by Bajolle et al revealed that bocavirus was present in the serum of 3/32 (9%) and in the nasopharyngeal aspirate of 7/32 (21.8%) patients with KD, who probably had a previous bocavirus infection heralding KD. 42 Metagenomic sequencing and PCR detected torque teno virus 7 in only 2/11 (18%) patients with KD prospectively evaluated for one year, 43 while the most recent reports have highlighted the association of KD with Epstein-Barr virus, 44 parvovirus B19 45 and influenza virus. 46 The Outbreak of the New Coronavirus and Kawasaki Disease.…”

Section: A Systemic Vasculitis Is the Key To Explain Kawasakimentioning

confidence: 99%

- Kawasaki Disease as the Immune-Mediated Echo of a Viral Infection

Rigante

2020

Mediterr J Hematol Infect Dis

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Although etiology of Kawasaki disease remains elusive, the available evidence indicates that the primum movens might be a dysregulation of immune responses to various microbes, i.e. a kind of immune-mediated response induced by a viral infection. Even if several data might suggest that Kawasaki disease is an infection-related clinical syndrome, which can develop only in children with a predisposing genetic background, our knowledge on both the infectious agents involved and the genetic characteristics of children prone to the disease remains poor.

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“…Multiple infectious triggers such as adenovirus and New Haven coronavirus have been inconclusively associated with KD in the past [ 7 , 8 ]. Also, KD has been in associations with Epstein–Barr virus (EBV), rotavirus, and bacteria [ 9 , 10 ]. In this regard, the WHO has also developed a preliminary case definition and case report form for MIS in children and adolescents for approaching these diseases [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

Multisystem Inflammatory Syndrome with Features of Atypical Kawasaki Disease during the COVID-19 Pandemic

Shahriarirad

Dashti

Ghotbabadi

2021

Case Reports in Pediatrics

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Background. Although Kawasaki disease (KD) is the most common self-limited systemic vasculitis in pediatrics, the exact etiology of the disease, its association with other diseases, and pathogens is still unknown. In order to achieve a better understanding and management of the disease, documentation and reporting of atypical cases is justified, particularly with the growing number of children with inflammatory syndrome with clinical features simulating KD during the COVID-19 pandemic. Here, we present a case of an atypical case of KD presenting as multisystem inflammatory syndrome (MIS) during the COVID-19 pandemic. Case Presentation. The patient is a 7-year-old girl who developed fever (39°C) and erythematous multiform rash on the abdomen and along with erythema and edema on the extremities. Laboratory evaluation revealed neutrophilia and lymphopenia along with elevated C-reactive protein, erythrocyte sedimentation rate, troponin, lactate dehydrogenase, ferritin, and D-dimer. Although the patient did not fulfill the KD criteria, based on approved guidelines and approaches regarding atypical KD and multisystem inflammatory syndrome in children (MIS-C) during the COVID-19 pandemic, intravenous immunoglobulin along with aspirin was administered for the patients. The patient’s symptoms resolved with an uneventful postdischarge course. Conclusion. Early diagnosis and treatment of patients meeting full or partial criteria for KD are critical to preventing end-organ damage and other long-term complications, especially during times of public crisis and global health emergencies, such as the novel coronavirus pandemic.

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Kawasaki disease triggered by EBV virus in a child with Familial Mediterranean Fever

Cited by 12 publications

References 20 publications

COVID-19 Pandemic in the Disguise of Multi System Inflammatory Syndrome in Children: A Case Series

COVID-19 Pandemic in the Disguise of Multi System Inflammatory Syndrome in Children: A Case Series

- Kawasaki Disease as the Immune-Mediated Echo of a Viral Infection

Multisystem Inflammatory Syndrome with Features of Atypical Kawasaki Disease during the COVID-19 Pandemic

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