KCNQ Channels and Novel Insights Into Coronary Perfusion

Gollasch, Maik

doi:10.1161/hypertensionaha.113.01869

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…Interestingly the BK Ca activator, NS‐1619 (30–50 μ M) induced similar vasorelaxation in both arteries (Figure S2C), suggesting that under basal conditions coronary circulation is more dependent on BK Ca than Kv7 channels. Further supporting this and as noted by Gollasch in the studies of Khanamiri et al. , Kv7 blockers (linopirdine and XE991) caused only a very modest reduction in flow (approximately 5–9% of baseline flow) in isolated perfused heart preparations.…”

Section: Discussionsupporting

confidence: 76%

“…To date, 5 subtypes of Kv7 channels encoded by KCNQ genes have been identified . Previously, we have shown heterogeneity in ion channel subunit expression between vascular beds with emphasis on differences in the molecular composition and role of BK Ca channels between the cerebral and the cremaster muscle vascular beds . Little is known, however, as to differences in the role of Kv7 channels between the cerebral and coronary vasculature, despite both these being vital organs and sites contributing to the morbidity and mortality associated with cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

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Heterogeneity in Kv7 Channel Function in the Cerebral and Coronary Circulation

Lee

Yang²,

Tanner³

et al. 2015

Microcirculation

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Kv7 channels are considered important regulators of vascular smooth muscle contractility. The present study examined the hypotheses that 1. Kv7 channels are present in mouse cerebral and coronary arteries and regulate vascular reactivity, and 2. regional differences exist in the activity of these channels. PCR confirmed that basilar, Circle of Willis and left anterior descending (LAD) arteries express predominantly Kv7.1 and 7.4. Western blot analysis, however, showed greater Kv7.4 protein levels in the cerebral vessels. Relaxation to the Kv7 channel activator, retigabine (1-50μM) was significantly greater in basilar compared to LAD. Similarly, the Kv7 channel inhibitor, linopirdine (10μM) caused stronger contraction of the basilar artery. Furthermore, pre-incubation with linopirdine reduced forskolin (cAMP activator)-induced vasorelaxation in basilar while not altering forskolin-induced vasorelaxation of the LAD, suggesting that Kv7 channels play a more prominent role in the cerebral than coronary circulation. Consistent with the vessel data, whole cell Kv7 currents in cerebral VSMCs were potentiated by retigabine and inhibited by linopirdine, while these responses were blunted in coronary VSMCs. This study provides evidence that mouse Kv7 channels may contribute differently to regulating the functional properties of cerebral and coronary arteries. Such heterogeneity has important implications for developing novel therapeutics for cardiovascular dysfunction.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Heterogeneity in Kv7 Channel Function in the Cerebral and Coronary Circulation

Lee

Yang²,

Tanner³

et al. 2015

Microcirculation

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A Clinical Perspective: Contribution of Dysfunctional Perivascular Adipose Tissue (PVAT) to Cardiovascular Risk

Lian

Gollasch

2016

Curr Hypertens Rep

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Perivascular adipose tissue (PVAT) is now recognized as an important paracrine organ influencing the homeostasis of the vessel wall, regional blood flow and peripheral arterial resistance. There is remarkable phenotypic variability and plasticity of PVAT among various vascular beds, exhibiting phenotypes from white to brown and beige adipocytes. PVAT dysfunction is characterized by disturbed secretion of various adipokines, which, together with endothelial dysfunction, contribute to hypertension and cardiovascular disease (CVD). This brief review describes our current knowledge on PVAT in health and cardiovascular disease, with a special focus on different phenotypes and signaling pathways in adipocytes of PVAT associated with hypertension, obesity and cardiovascular disorders.

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