KDM5 Family Demethylase Inhibitor KDOAM-25 Reduces Entry of SARS-CoV-2 Pseudotyped Viral Particles into Cells

Knyazev, E. N.; Kalinin, R. S.; Abrikosova, V. A.; Mokrushina, Yuliana A.; Tonevitskaya, S. A.

doi:10.1007/s10517-023-05827-w

Bull Exp Biol Med

2023

DOI: 10.1007/s10517-023-05827-w

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KDM5 Family Demethylase Inhibitor KDOAM-25 Reduces Entry of SARS-CoV-2 Pseudotyped Viral Particles into Cells

E. N. Knyazev

R. S. Kalinin

V. A. Abrikosova

et al.

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2024

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Histone Demethylases

Kales,

Simeonov

2024

Epigenetic Drug Discovery

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Histone methylation is a dynamic process that contributes to the control of gene expression by influencing chromatin structure. Since their initial discovery 20 years ago, histone demethylases have been shown to play a critical role in histone methylation and thus developmental, physiological, and pathological processes. Dysregulation of this class of enzymes has been linked to nearly all types of cancers but their complex interactions and elusive functions continue to impede therapeutic development. Here, we explore the demethylase family, its sub-families, and the great efforts to identify novel, specific inhibitors to understand their complex biological functions and therapeutic potential.

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Histone Demethylases

Kales,

Simeonov

2024

Epigenetic Drug Discovery

View full text Add to dashboard Cite

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Drug Discovery for Chromatin Readers, Writers, Erasers, Remodelers and Epitranscriptomic Targets

2024

Epigenetic Drug Discovery

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scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

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KDM5 Family Demethylase Inhibitor KDOAM-25 Reduces Entry of SARS-CoV-2 Pseudotyped Viral Particles into Cells

Cited by 2 publications

References 30 publications

Histone Demethylases

Histone Demethylases

Drug Discovery for Chromatin Readers, Writers, Erasers, Remodelers and Epitranscriptomic Targets

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