The purpose of this study was to analyze the direct and indirect effect of Organizational Culture, Spiritual Quotient on Job Satisfaction and Performance of State Senior High School Teachers in Jekan Raya, Palangka Raya. This research employed a quantitative with correlation technique (correlational research). The research population was teachers of three schools in Palangka Raya, namely SMAN 3 Palangka Raya, SMAN 4 Palangka Raya and SMAN 5 Palangka Raya. As many as 238 teachers and 159 respondents were taken as research samples taken with random sampling technique. The data were collected by using a questionnaire instrument Organizational Culture (25 items), Spiritual Quotient (12 items), Job Satisfaction (21 items) and Teacher Performance (19 items). The data was analyzed by using path analysis. The results of this study indicate that the value of the variable regression coefficient is a positive number such as Organizational Culture (X1 ) with Job Satisfaction (Z) of 0.689, Organizational Culture (X1 ) with Teacher Performance (Y) of 0.621, Spiritual Quotient (X2 ) with Job Satisfaction (Z) is 1.499, Spiritual Quotient (X 2 ) with Teacher Performance (Y) is 1.348, Job Satisfaction (Z) is with Teacher Performance (Y) is 0.908, Organizational Culture (X 1 ) is Job Satisfaction (Z) through Teacher Performance (Y) is 0.563, Spiritual Quotient (X2 ) with Job Satisfaction (Z) through Teacher Performance (Y) is 1.223.