Keeping It Simple: Using Intestinal Ultrasound to Assess Ulcerative Colitis with a Novel UC-Ultrasound Index

Delisle, Maxime; Wilkens, Rune; Novak, Kerri L.

doi:10.1093/ecco-jcc/jjab066

Cited by 3 publications

(4 citation statements)

References 11 publications

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“…Maximum numerical points total will be recorded for continuous variables within these segments as well as binary scores for parameters which can be defined as either present/absent. Parameter measurement will be made in line with International Bowel Ultrasound Group consensus guidance 25. An overall composite score of these parameters will be recorded.…”

Section: Methods and Analysismentioning

confidence: 99%

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NIMBUS study protocol: a single-centre feasibility study of non-invasive monitoring with bowel ultrasound in paediatric inflammatory bowel disease

Green,

Mayberry,

Ashton

et al. 2023

BMJ Open

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IntroductionIncidence of inflammatory bowel disease (IBD) is increasing in childhood and treatment increasingly targets mucosal healing. Monitoring bowel inflammation requires endoscopy or MRI enterography which are invasive, expensive and have long waiting lists.We aim to examine the feasibility of a non-invasive monitoring tool—bowel ultrasound (BUS)—in children with IBD and explore correlations with inflammatory markers and disease activity measures. Some BUS criteria have been found to correlate with these markers; however, this has not been validated in children.We aim to examine the feasibility of BUS for monitoring inflammation in this population; highlighting useful parameters for this purpose. We aim to inform a larger scale randomised controlled trial using BUS.Methods and analysisThis prospective observational feasibility study will be carried out over 24 months at the Noah’s Ark Children’s Hospital for Wales, Cardiff; with the endpoint recruitment of 50 participants. Children aged 2–18 years with a modified Porto criteria diagnosis of IBD will be included.Patients without IBD or who have previously undergone IBD-related surgery will be excluded; as will families unable to give informed consent.Ultrasound scan images and reports will be collected, as well as laboratory results and clinical outcomes.The primary aim will assess the feasibility of targeted BUS for disease monitoring; including recruitment statistics. The secondary aims will involve data collection and correlation analysis for targeted ultrasound parameters, biomarkers, disease activity scores and prediction of changes in treatment. The statistical methods will include: feasibility metrics, descriptive statistics, cross-tabulation and χ2analysis, correlation analysis, regression analysis.Ethics and disseminationEthical approval is granted by NHS Research Ethics Committee. The sponsor is Cardiff and Vale University Health Board. We will publish the results in a peer-reviewed medical journal.Trial registration numberNCT05673278.

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Section: Methods and Analysismentioning

confidence: 99%

“…Parameter measurement will be made in line with International Bowel Ultrasound Group consensus guidance. 25 An overall composite score of these parameters will be recorded.…”

Section: Methods and Analysismentioning

confidence: 99%

NIMBUS study protocol: a single-centre feasibility study of non-invasive monitoring with bowel ultrasound in paediatric inflammatory bowel disease

Green,

Mayberry,

Ashton

et al. 2023

BMJ Open

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show abstract

Section: Introductionmentioning

confidence: 99%

“…Ulcerative colitis (UC) is the inflammation of the rectal mucosa that usually extends proximally to other areas of the colon [ 1 ]. UC is characterized by cytokine imbalance, immune dysfunction and intestinal mucosa-associated inflammation [ 1 ]. UC patients generally present with bloody diarrhea, abdominal pain and tenesmus, with increasing global incidence [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Network pharmacology for systematic understanding of Schisandrin B reduces the epithelial cells injury of colitis through regulating pyroptosis by AMPK/Nrf2/NLRP3 inflammasome

Zhang

Wang

Shen

et al. 2021

Aging

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Ulcerative colitis (UC) is a chronic inflammatory disease with increasing incidence and prevalence in many countries. The purpose of this study is to explore the function of Schisandrin B and its underlying molecular mechanisms in colitis. In this study, mice with colitis were induced by giving 2.0% dextran sulfate sodium (DSS, MP) in the drinking water for seven days. Furthermore, TCMSP server and GEO DataSets were used to analyze the mechanism of Schisandrin B in colitis. It was found that Schisandrin B presented colitis in mice model. At the same time, Schisandrin B not only reduced inflammation in vivo and vitro model of colitis, but also suppressed the nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain-containing 3 (NLRP3) inflammasome in vivo and vitro model of colitis. In addition, Schisandrin B induced AMP-activated protein kinase (AMPK) / Nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway in model of colitis, and regulated AMPK protein at 316 sites. The inhibition of AMPK reduced the anti-inflammation effects of Schisandrin B on NLRP3 inflammasome. Apart from that, Schisandrin B decreased reactive oxygen species (ROS)-induced mitochondrial damage and reduced epithelial cells damage of colitis through regulating pyroptosis. Collectively, our novel findings for first time showed that, Schisandrin B suppressed NLRP3 inflammasome activation-mediated interleukin-1beta (IL-1β) level and pyroptosis in intestinal epithelial cells of colitis model through the activation of AMPK/Nrf2 dependent signaling-ROS-induced mitochondrial damage, which may be a significant therapeutic approach in the treatment of acute colitis.

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WITHDRAWN: The application of Traditional Chinese Medicine in the treatment of ulcerative colitis and the elucidation of relevant mechanisms

ZHU,

WANG,

Aisikaer

et al. 2024

Pharmacological Research - Natural Products

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Keeping It Simple: Using Intestinal Ultrasound to Assess Ulcerative Colitis with a Novel UC-Ultrasound Index

Cited by 3 publications

References 11 publications

NIMBUS study protocol: a single-centre feasibility study of non-invasive monitoring with bowel ultrasound in paediatric inflammatory bowel disease

NIMBUS study protocol: a single-centre feasibility study of non-invasive monitoring with bowel ultrasound in paediatric inflammatory bowel disease

Network pharmacology for systematic understanding of Schisandrin B reduces the epithelial cells injury of colitis through regulating pyroptosis by AMPK/Nrf2/NLRP3 inflammasome

WITHDRAWN: The application of Traditional Chinese Medicine in the treatment of ulcerative colitis and the elucidation of relevant mechanisms

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