Kefir Ameliorates Alcohol‐Induced Liver Injury Through Modulating Gut Microbiota and Fecal Bile Acid Profile in Mice

Cui, Yuanyuan; Jing, Chun; Yue, Yuan; Ning, Mengge; Chen, Hong; Yuan, Yahong; Yue, Tianli

doi:10.1002/mnfr.202300301

Cited by 9 publications

(1 citation statement)

References 66 publications

(99 reference statements)

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“…The serum was stored at −20 • C for later use (Cui et al, 2024). Following blood extraction, fecal samples were collected from each mouse and frozen at −80 • C. The liver tissue was extracted, washed with normal saline, and dried with filter paper.…”

Section: Groupmentioning

confidence: 99%

Structural characterization of Aspalatus linearis polysaccharide and its improving effect on acute alcoholic liver injury

Zhang,

Liu,

et al. 2024

Journal of Food Science

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Polysaccharides from natural sources can regulate the composition of intestinal flora through the “gut‐liver axis” pathway, potentially ameliorating alcoholic liver injury. Aspalathus linearis, also known as rooibos, is one such natural product that has shown promise in this regard. This study looked at the structural properties of A. linearis polysaccharide (ALP) and how well it would work to treat acute alcoholic liver impairment. This study looks at the composition of monosaccharides, functional groups, and molecular weight (Mw) of a newly discovered water‐soluble polysaccharide, named ALP. The polysaccharide is composed of pyranose rings, amide groups, and sulfate groups linked by β‐glycosidic linkage. It has a relative Mw of 4.30 × 103 kDa and is composed of glucose, rhamnose, and some other monosaccharides. The study found that treating mice with the model of acute alcoholic liver disease with ALP could alleviate pathological symptoms, inhibit the release of inflammatory cytokines, and suppress indicators of oxidative stress. Experiments have shown that different doses of ALP can activate the P4502E1/Keap1‐Nrf2‐HO‐1 signaling pathway. The regulation of inflammatory factors and downstream antioxidant enzymes occurs as a result. Based on these data, it is likely that ALP protects the liver via the “gut‐liver axis” pathway by reducing oxidative stress‐related damage, inflammation, and alcohol‐related alterations to the gut microbiome. The results indicate that ALP mitigates injury caused by oxidative stress, inflammatory responses, and changes in the gut microbiota induced by alcohol through the “gut‐liver axis” pathway, which provides protection to the liver. This provides preliminary evidence for the development of related drugs.Practical ApplicationResearchers extracted a polysaccharide from fresh leaves of Auricularia auricula. The polysaccharide was purified and determined to have a predominantly homogeneous molecular weight. An acute alcoholic liver damage mouse model was established, and it was concluded that the polysaccharide could ameliorate liver injury in mice through the “gut‐liver axis” pathway. This novel polysaccharide can be used as an additive to develop functional foods with beneficial effects, which can positively impact the daily maintenance of consumers.

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Section: Groupmentioning

confidence: 99%

Structural characterization of Aspalatus linearis polysaccharide and its improving effect on acute alcoholic liver injury

Zhang,

Liu,

et al. 2024

Journal of Food Science

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Effects of kefir consumption on gut microbiota and health outcomes in women with polycystic ovary syndrome

Çıtar Dazıroğlu,

Acar Tek,

Cevher Akdulum

et al. 2024

Food Science & Nutrition

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Polycystic Ovary Syndrome (PCOS), which is common among women of reproductive age, is characterized by low‐grade chronic inflammation and is associated with several health problems and dysbiosis. Kefir has been shown to have many beneficial health effects; however, its effect on PCOS is unknown. This study aimed to examine the effect of kefir on the intestinal microbiota and health outcomes in PCOS. In this intervention study, 17 women with PCOS consumed 250 mL/day of kefir (containing Lactobacillus kefiranofaciens subsp. kefiranofaciens, Lactobacillus kefiranofaciens subsp. kefirgranum, Lactobacillus kefiri, Lactobacillus acidophilus, Lactobacillus parakefiri, Lactobacillus bulgaricus, Lactobacillus reuteri, Lactobacillus casei, Lactobacillus fermentum, Lactobacillus helveticus, Lactococcus lactis, Leuconostoc mesentereoides, Bifidobacterium bifidum, Streptococcus thermophilus, Kluyveromyces marxianus, Kluyveromyces lactis, Acetobacter pasteurianus, and Saccharomyces cerevisiae) for 8 weeks. Food consumption and physical activity records, anthropometrical measurements, quality of life, and fecal and blood samples were taken at the study's beginning and end. Quality of life in mental health (58.8 ± 15.08; 64.0 ± 15.23, respectively) and physical function (95.00 and 100.00, respectively) categories showed a significant increase after kefir intervention (p < .05). Additionally, Interleukin‐6 (IL‐6), one of the inflammatory cytokines, significantly decreased (174.00 and 109.10 ng/L, respectively) (p < .05). The intestinal barrier permeability was evaluated with zonulin, and no significant change was observed. Gut microbiota analysis showed that while the relative abundance of the class Bacilli and genus Lactococcus significantly increased, the genus Holdemania decreased with kefir consumption (p < .05). In conclusion, kefir appears to be beneficial for improving the microbiota and some health outcomes, like reducing inflammation and improving quality of life in PCOS. Therefore, kefir may be useful in the treatment of PCOS.

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Protective effects of polysaccharides from Polygonatum cyrtonema on the acute alcohol induced liver damage

Gui,

Zheng,

Huang

et al. 2024

Food Bioscience

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Kefir Ameliorates Alcohol‐Induced Liver Injury Through Modulating Gut Microbiota and Fecal Bile Acid Profile in Mice

Cited by 9 publications

References 66 publications

Structural characterization of Aspalatus linearis polysaccharide and its improving effect on acute alcoholic liver injury

Structural characterization of Aspalatus linearis polysaccharide and its improving effect on acute alcoholic liver injury

Effects of kefir consumption on gut microbiota and health outcomes in women with polycystic ovary syndrome

Protective effects of polysaccharides from Polygonatum cyrtonema on the acute alcohol induced liver damage

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