Kefir protective effects against nicotine cessation-induced anxiety and cognition impairments in rats

Noori, Negin; Bangash, Mohammad Yasan; Motaghinejad, Majid; Hosseini, Pantea; Noudoost, Behshad

doi:10.4103/2277-9175.146377

Cited by 26 publications

(16 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Before the tests starts, the animals were allowed to adapt themselves to the laboratory for at least 2 hr and they were used only once. All experimental procedures followed the Guidelines on Ethical Standards for investigation of experimental pain in animals ( Motaghinejad et al, 2014b ; Motaghinejad et al, 2015a ; Noori et al, 2014 ; Shojaii et al, 2015 ).…”

Section: Methodsmentioning

confidence: 99%

The effect of maternal forced exercise on offspring pain perception, motor activity and anxiety disorder: the role of 5-HT2 and D2 receptors and CREB gene expression

Motaghinejad

Motevalian

et al. 2017

J Exerc Rehabil

Self Cite

View full text Add to dashboard Cite

The effect of maternal forced exercise on central disorders in offsprings has been shown but the mechanism is still unclear. In this study, the role of 5-HT2 and D2 receptors in neuroprotective effects of maternal forced exercise on offspring neurodevelopment and neurobehavioral symptoms is evaluated. Sixty pregnant rats were trained by forced exercise and some behavioral and molecular aspects in their offspring were evaluated in presence of 5-HT2 and D2 receptors agonists and antagonists. The results showed that maternal forced exercise causes increase of pain tolerability and increase latency of pain perception in offspring in hot plate test, writhing test and tail flick test. Also maternal forced exercise causes decrease of depression and anxiety like behavior in offsprings. On the other hand, treatment of mothers by forced exercise in combination with 5-HT2 and D2 receptor antagonists inhibited the protective effects of forced exercise and cause disturbance in pain perception and tolerability and increase depression and anxiety in offsprings. Also expression of cyclic AMP response element binding protein (CREB) was changed in all experimental groups. In conclusion, our data suggested that maternal forced exercise causes neurobehavioral protective effect on offsprings and this effect might probably be mediated by 5-HT2 and D2 receptors and activation of CREB gene expression.

show abstract

Section: Methodsmentioning

confidence: 99%

The effect of maternal forced exercise on offspring pain perception, motor activity and anxiety disorder: the role of 5-HT2 and D2 receptors and CREB gene expression

Motaghinejad

Motevalian

et al. 2017

J Exerc Rehabil

Self Cite

View full text Add to dashboard Cite

show abstract

“…The preference for being in closed arms over the open ones was indicative of depressive behavior. [2528]…”

Section: Methodsmentioning

confidence: 99%

Study of the effects of controlled morphine administration for treatment of anxiety, depression and cognition impairment in morphine-addicted rats

et al. 2016

Self Cite

View full text Add to dashboard Cite

Background:Morphine dependency usually results in undesired outcomes such as anxiety, depression, and cognitive alterations. In this study, morphine was used to manage morphine dependence-induced anxiety, depression, and learning and memory disturbances.Materials and Methods:Forty rats were divided equally into five groups. Group 1 received saline for 21 days. Groups 2–5 were dependent by increasing administration of morphine (15–45 mg/kg) for 7 days. For the next 14 days, morphine was administered as the following regimen: Group 2: once daily; 45 mg/kg (positive controls), Group 3: the same dose with an increasing interval (6 h longer than the previous intervals each time), Group 4: the same dose with an irregular intervals (12, 24, 36 h intervals interchangeably), and Group 5: decreasing doses once daily (every time 2.5 mg/kg less than the former dosage). On days 22–26, elevated plus maze (EPM), open field test (OFT), forced swim test (FST), and tail suspension test (TST) were performed to investigate anxiety level and depression in animals. Between 17th and 21st days, Morris water maze (MWM) was used to evaluate the spatial learning and memory.Results:Chronic morphine administration caused depression and anxiety as observed by FST, EPM, and TST and decreased motor activity in OFT and caused impairment in learning and memory performance in MWM. Treatment with our protocol as increasing interval, irregular interval, and decreasing dosage of morphine caused marked reduction in depression, anxiety, and improved cognition performance compared with positive control group; and attenuated motor deficits in morphine-dependent rats, remarkably.Conclusions:Change in dosage regimens of morphine can reduce morphine-induced anxiety, depression, and cognitive impairments.

show abstract

“…Investigations have confirmed that nicotine withdrawal syndrome after chronic administration and adaptations can cause increased anxiety and depression [1,6,7]. On the other hand, the anxiety and depression observed during nicotine withdrawal are major concerns for designing nicotine dependency treatment protocols [1,6,8,9]. Taking these concerns into account, some anxiolytic and antidepressant agents are being used alongside nicotine withdrawal syndrome management [10,11].…”

Section: Introductionmentioning

confidence: 99%

Protective effects of forced exercise against nicotine-induced anxiety, depression and cognition impairment in rat

Motaghinejad

Fatima

Karimian

et al. 2015

Journal of Basic and Clinical Physiology and Pharmacology

Self Cite

View full text Add to dashboard Cite

Background: Nicotine is one of the psychostimulant agents displaying parasympathomimetic activity; the chronic neurochemical and behavioral effects of nicotine remain unclear. Exercise lowers stress and anxiety and can act as a non-pharmacologic neuroprotective agent. In this study, the protective effects of exercise in nicotine withdrawal syndrome-induced anxiety, depression, and cognition impairment were investigated. Methods: Seventy adult male rats were divided randomly into five groups. Group 1 served as negative control and received normal saline (0.2 mL/rat, i.p.) for 30 days, whereas group 2 (as positive control) received nicotine (6 mg/kg/day, s.c.) for the first 15 days. Groups 4, 5, and 6 were treated with nicotine (6 mg/kg/day, s.c.) for the first 15 days and then were treated with forced exercise, bupropion (20 mg/kg/day, i.p.), or a combination of the two for the following 15 days. Between day 25 and day 30, Morris water maze was used to evaluate spatial learning and memory. From days 31 to 35, the elevated plus maze (EPM), open field test (OFT), forced swim test (FST), and tail suspension test (TST) were used to investigate the level of anxiety and depression in the subjects. Results: Nicotine-dependent animals indicated a reflective depression and anxiety in a dose-dependent manner in FST, EPM, and TST, which were significantly different from the control group and also can significantly attenuate the motor activity and anxiety in OFT. Conclusions: Forced exercise, bupropion, or their combination can attenuate nicotine cessation-induced anxiety,

show abstract

Kefir protective effects against nicotine cessation-induced anxiety and cognition impairments in rats

Cited by 26 publications

References 38 publications

The effect of maternal forced exercise on offspring pain perception, motor activity and anxiety disorder: the role of 5-HT2 and D2 receptors and CREB gene expression

The effect of maternal forced exercise on offspring pain perception, motor activity and anxiety disorder: the role of 5-HT2 and D2 receptors and CREB gene expression

Study of the effects of controlled morphine administration for treatment of anxiety, depression and cognition impairment in morphine-addicted rats

Protective effects of forced exercise against nicotine-induced anxiety, depression and cognition impairment in rat

Contact Info

Product

Resources

About