Keio Uterus Transplantation Research: From Basic Research toward          Future Clinical Application

Kisu, Iori; Banno, Kouji; Matoba, Yusuke; Yamada, Yasuaki; Emoto, Katsura; Masugi, Yohei; Murakami, Kentaro; Obara, Hideaki; Aoki, Daisuke

doi:10.2302/kjm.2021-0008-ir

Cited by 2 publications

(2 citation statements)

References 41 publications

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“…UTx is a new concept in the field of infertility treatment, and transplant centers are expanding globally. Programs for UTx have been or will be launched in Australia, 42 Japan, 43 the United Kingdom, 44 the Netherlands, 45 South Korea, 35 Singapore, 35 Taiwan, 35 Egypt, 35 Mexico, 35 Colombia, and Argentina 35 …”

Section: Resultsmentioning

confidence: 99%

Miracles of science: Birth after uterus transplantation

Ongun,

Celik,

Arayici

et al. 2023

J of Obstet and Gynaecol

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AimThe concept of regaining childbearing ability via uterus transplantation (UTx) motivates many infertile women to pursue giving birth to their own children. This article provides insight into maternal and neonatal outcomes of the procedure globally and facilitates quality of care in related medical fields.MethodsThe authors searched ISI Web of Science, MEDLINE, non‐PubMed‐indexed journals, and common search engines to identify peer‐review publications and unpublished sources in scientific reference databases.ResultsThe feasibility of the procedure has been proven with 46 healthy children in 88 procedures so far. Success relies upon dedicated teamwork involving transplantation surgery, obstetrics and reproductive medicine, neonatology, pediatrics, psychology, and bioethics. However, challenges exist owing to donor, recipient, and fetus. Fetal growth in genetically foreign uterine allograft with altered feto‐maternal interface and vascular anatomy, immunosuppressive exposure, lack of graft innervation leading to “unable‐to‐feel” uterine contractions and conception via assisted reproductive technology create notable risks during pregnancy. Significant portion of women are complicated by at least one or more obstetric problems. Preeclampsia, gestational hypertension and diabetes mellitus, elevated kidney indices, and preterm delivery are common complications.ConclusionsUTx has short‐ and long‐term satisfying outcome. Advancements in the post‐transplant management would undoubtedly lead this experimental procedure into mainstream clinical practice in the near future. However, both women and children of UTx need special consideration due to prematurity‐related neonatal problems and the long‐term effects of transplant pregnancy. Notable health risks for the recipient and fetus should be discussed with potential candidates for UTx.

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Section: Resultsmentioning

confidence: 99%

Miracles of science: Birth after uterus transplantation

Ongun,

Celik,

Arayici

et al. 2023

J of Obstet and Gynaecol

View full text Add to dashboard Cite

show abstract

“…In the report, it is also concluded that patients with MRKHS need multifaceted support from a comprehensive perspective that takes into account the physical and social impacts of disease diagnosis and notification on the individual and their families. 4 In the wake of UTx research, the increased awareness of the situation of patients with MRKHS among the public and gynecologists is of great significance to the patients. To improve the sexual well-being and reproductive health among these patients in Japan, comprehensive postoperative management for patients with MRKHS following vaginoplasty is warranted.…”

mentioning

confidence: 99%