ABSTRAK Sebagian besar penduduk di daerah pedesaan bertaraf ekonomi menengah ke bawah, memiliki keterbatasan akses informasi, dan memiliki mata pencaharian berbeda dibanding penduduk kota. Bantar Kulon merupakan daerah pedesaan dan Kronggahan adalah daerah perkotaan di Yogyakarta. Mengingat terjadinya pergeseran pola penyakit dari penyakit menular ke penyakit tidak menular serta adanya pengaruh lingkungan dan gaya hidup terhadap terjadinya penyakit degeneratif, dilakukan pengkajian mengenai faktor risiko sindroma metabolik di dua daerah tersebut. Penelitian ini dilakukan untuk mengetahui apakah ada perbedaan kadar glukosa darah puasa (GDP) dan tekanan darah (TD), serta keluhan/ penyakit utama pada penduduk di daerah pedesaan dan perkotaan. Sebanyak 71 orang dari Bantar Kulon dan 91 orang dari Kronggahan diperiksa kadar GDP menggunakan GCU Multi-Function Monitoring System (EasyTouch®). Tekanan darah diperiksa menggunakan sphygmomanometer raksa dan otomatis. Faktor risiko GDP dan TD kedua lokasi ditampilkan dalam bentuk deskriptif berdasarkan cut-off (GDP: ≥100mg/dL; TD: ≥140/90 mmHg). Uji t atau Mann Whitney U dilakukan untuk mengetahui perbedaaan nilai variabel antar kedua lokasi. Hasil dinyatakan berbeda bermakna jika p<0,05. Data keluhan kesehatan ditampilkan secara deskriptif. Tidak ada perbedaan kadar GDP antara desa dan kota (p=0,385). Persentase subjek yang memiliki GDP ≥ 100 mg/dL lebih banyak di kota dibanding desa (42,3% vs 26,4%). Persentase hipertensi berdasarkan pemeriksaan lebih tinggi di kota dibanding desa (50,5% vs 33,8%). Berdasarkan wawancara, keluhan/ penyakit tertinggi pada kedua wilayah adalah hipertensi sebanyak 23 orang (33,82%) di desa dan 30 (32,97%) di kota. Disimpulkan bahwa faktor risiko GDP di atas normal lebih banyak ditemukan di desa sedangkan hipertensi lebih banyak ditemukan di kota. Keluhan/ penyakit utama di kedua wilayah adalah hipertensi.KATA KUNCI kadar glukosa darah; penyakit metabolik; hipertensi; pedesaan; perkotaan ABSTRACT Most people living in rural areas are from lower to middle income class, have limited access to information, and have different occupations compared to those in urban areas. In Yogyakarta, Bantar Kulon is a rural area, while Kronggahan is an urban area. Currently, the pattern of disease is shifting from infectious diseases to non-communicable diseases with environment and lifestyle factors as determinants. Thus, it is necessary to study the trends of risk factors for metabolic syndrome in both areas. This study aimed to seek the difference of fasting blood glucose (FBG), blood pressure (BP), and major complaints/illness between rural and urban areas. 71 people from Bantar Kulon and 91 people from Kronggahan were examined for FBG levels using GCU Monitoring System (EasyTouch®). Blood pressures were checked using sphygmomanometer. Risk factors for FBG and BP were presented as frequencies based on cut-offs (FBG: ≥100mg/dL; BP: ≥140/90 mmHg). T-test or Mann-Whitney U test were used to analyze the difference in variables between both areas. Results were significantly different if p <0.05. Health complaint data were displayed descriptively. There was no difference in FBG level between rural and urban areas (p = 0.385). The percentage of subjects with FBG ≥ 100 mg / dL was higher in Kronggahan than in Bantar Kulon (42.3% vs 26.4%). Based on examination, percentage of hypertension was higher in urban than rural areas (50.5% vs. 33.8%). Based on interviews, the top complaint/ disease in both areas was hypertension. The number of subjects who were diagnosed with hypertension were 23 (33,82%) and 30 (32,97%) from Bantar Kulon and Kronggahan respectively. Impaired fasting glucose was more common in Bantar Kulon (rural area) while hypertension is more common in Kronggahan (urban area). The main complaint / disease in both regions is hypertension.KEYWORDS blood glucose; metabolic syndrome; hypertension; rural area; urban area