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Abstract

In this study, we investigated anti-cancer and antimicrobial activity of Aegle marmelos leaf extracts and their chemical profile characterized by gas chromatography coupled mass spectrometry (GC-MS). A. marmelos leaves were extracted with acetone, methanol, ethanol, and chloroform. Presence of phenolic compounds was identified in these extracts by qualitative analysis. All the extracts were subjected for anti-bacterial activity against the different strains of bacteria (Staphylococcus aureus, Bacillus subtilis, Bacillus cereus, Bacillus ariyabattai, Bacillus megaterium, Pseudomonas putida, Klebsiella pneumonia, Serratia marcescens, and Escherichia coli). It is noteworthy that acetone extract elicited maximum growth inhibition on Serratia marcescens. Based on profound anti bacterial activity, acetone and methanol extract of A. marmelos were checked for cytotoxicity against MDA-MB-231, HEp-2 and vero cells. MDA-MB-231 cells were more sensitive to acetone extract of A. marmelos with an IC 50 value of 79.62 µg/ml where as HEp-2 cells are more sensitive to methanol extract of A. marmelos with an IC 50 value of 47.08 µg/ml. Vero cells withstand 24 h treatment of both extract, and it is evidenced that both acetone and methanol extract of A. marmelos exhibited chemo sensitive property towards cancer cells. GCMS analysis was performed to characterize the active principles of acetone and methanol extracts of A. marmelos. GC MS data revealed the presence of ten major components. Overall, both acetone and methanol extract of A. marmelos found to be promising anti antibacterial and anti-cancer agent however the active principle of these should be isolated and characterized before reaching a concrete scientific conclusion. INTRODUCTION: Nature has wealthy medicinal resources which can cure the ailment of humanity.

Ethnomedicinal properties of Bael Aegle marmelos Corrêa family Rutaceae: A review

“…The acetone extract showed terpenoids in addition to all the phytochemicals detected for methanol extract but not the steroids. The terpenoids, flavonoids, saponins, tannins, steroids, glycosides, phlobatannins, quinones coumarins, sugars, and proteins were detected in the chloroform extract [50] . The ethyl acetate extract of the Bael stem showed the presence of alkaloids (Table 2) [51] .…”