Keloid scarring, but not Dupuytren’s contracture, is associated with unexplained carotid atherosclerosis

Abstract

Background: Atherosclerosis, a response to injury, may be thought of as scarring in the artery wall. TGF-and associated signaling molecules have been implicated in the pathophysiology of keloid scarring, Dupuytren's Contracture and atherosclerotic plaques in independent studies. Purpose: To test the hypothesis that excess cutaneous scarring and Dupuytren's contractures predispose independently to carotid atherosclerosis . Methods: Among 1,747 patients with plaque measurements and complete data for multivariable regression analysis, 57 Caucasian patients had Dupuytren's contractures and 12 had keloid scars. Carotid total plaque area (TPA) was measured by 2-Dimensional ultrasound. Results: In linear multivariable regression analysis with coronary risk factors, keloid scars were associated with TPA (P= 0.018), but Dupuytren's contractures were not. Patients with keloid scarring were younger (P<0.0001), and more likely to be diabetic (P<0.0001) Conclusions: Keloid scarring is a clinical clue to excess atherosclerosis not explained by traditional risk factors. Such patients may benefit from therapy directed at targets related to signalling molecules common to both the process of keloid scarring and atherosclerosis. These findings suggest previously unexplored possibilities for the prevention and treatment of atherosclerosis. The differences between

The Relationship between Proliferative Scars and Endothelial Function in Surgically Revascularized Patients

“…Moreover, Ozdol et al (20) investigated the percutaneously revascularized patients and suggested that patients with proliferative scars may have a higher risk of in-stent restenosis. In a similar study, Johnsen et al (21) found that carotid total plaque area, which is a stronger predictor of coronary events than intima media thickness, was significantly higher in keloid patients (22).…”

Erosive Arthritis, Fibromatosis, and Keloids: A Rare Dermatoarthropathy

“…However, it is thought that the fibroblasts are inherently unstable in keloids in contrast to palmar fibromatosis [ 10 ]. One study found increased incidence of carotid atherosclerotic plaque in keloid patients when compared to those with palmar fibromatosis [ 12 ]. They speculated that the myofibroblasts in these diseases originated from different cellular precursors.…”

Surgical considerations in skin of colour: minimizing pathological scars

“…Other relevant history includes age (older patients have a lower frequency of hypertrophic scars), ethnicity (keloids are more commonly found in African and Asian than in white populations), family history of pathological wound healing and current medical history 13 (e.g. diabetes, 14 pregnancy 15 and uncontrolled hypertension 16 ), all of which are known factors that adversely can influence wound healing and scar formation.…”