Keloids: a review of therapeutic management

Ekstein, Samuel F.; Wyles, Saranya P.; Moran, Steven L.; Meves, Alexander

doi:10.1111/ijd.15159

Cited by 125 publications

(142 citation statements)

References 100 publications

(236 reference statements)

Supporting

Mentioning

125

Contrasting

Unclassified

Order By: Relevance

“…Cutaneous pathological keloids are an abnormal fibroproliferative wound healing reaction (Ekstein et al, 2020). The etiology of keloids remains unclear but may be closely involved in genetics and external system factors (Tan et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Circular RNA CircCOL5A1 Sponges the MiR-7-5p/Epac1 Axis to Promote the Progression of Keloids Through Regulating PI3K/Akt Signaling Pathway

Liu

Zhang

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

Keloids, as a result of abnormal wound healing in susceptible individuals, are characterized by the hyper-proliferation of fibroblasts and exaggerated deposition of extracellular matrix. Current surgical and therapeutic modalities provide limited satisfactory results. Growing evidence has highlighted the roles of circRNAs in acting as miRNA sponges. However, up to date, the regulatory mechanism of circRNAs in the pathological process of keloids has rarely been reported. In this study, cell proliferation, cell migration, flow cytometry, western blotting, fluorescence in situ hybridization, dual-luciferase activity, and immunohistochemistry assays were applied to explore the roles and mechanisms of the circCOL5A1/miR-7-5p/Epac1 axis in the keloid. The therapeutic potential of circCOL5A1 was investigated by establishing keloid implantation models. The RT-qPCR result revealed that circCOL5A1 expression was obviously higher in keloid tissues and keloid fibroblasts. Subsequent cellular experiments demonstrated that circCOL5A1 knockdown repressed the proliferation, migration, extracellular matrix (ECM) deposition, whereas promoted cell apoptosis, through the PI3K/Akt signaling pathway. Furthermore, RNA-fluorescence in situ hybridization (RNA-FISH) illustrated that both circCOL5A1 and miR-7-5p were located in the cytoplasm. The luciferase reporter gene assay confirmed that exact binding sites were present between circCOL5A1 and miR-7-5p, as well as between miR-7-5p and Epac1. Collectively, the present study revealed that circCOL5A1 functioned as competing endogenous RNA (ceRNA) by adsorbing miR-7-5p to release Epac1, which contributed to pathological hyperplasia of keloids through activating the PI3K/Akt signaling pathway. Our data indicated that circCOL5A1 might serve as a novel promising therapeutic target and represent a new avenue to understand underlying pathogenesis for keloids.

show abstract

Section: Discussionmentioning

confidence: 99%

Circular RNA CircCOL5A1 Sponges the MiR-7-5p/Epac1 Axis to Promote the Progression of Keloids Through Regulating PI3K/Akt Signaling Pathway

Liu

Zhang

et al. 2021

Front. Cell Dev. Biol.

View full text Add to dashboard Cite

show abstract

“…In addition to laser therapy with TAC administration, a low recurrence rate is achieved when surgical excision is combined with other treatment modalities, such as TAC, 5-Fluorouracil, pressure therapy, silicone gel, electron beam, and radiation therapy (68). Although there are already many treatment modalities, no gold standard for keloid treatment has been established, and many efforts are being made in the exploration of new therapies (69).…”

Section: Research Focuses and Development Trends From 1990 To 2019mentioning

confidence: 99%

Scientific landscape and trend analysis of keloid research: a 30-year bibliometric review

Chong¹,

Long²,

Ho³

2021

Ann Transl Med

View full text Add to dashboard Cite

Background: Keloids remain troublesome for clinicians because of the lack of standard therapy, and the underlying mechanisms are still unclear. Bibliometric analysis could be a powerful tool to comprehensively review research trends, evaluate publication performances and provide future perspectives. There is no bibliometric analysis focusing on keloid research.Methods: Keloid related publications were searched in Web of Science Core Collection from the publication year 1990 to 2019. Bibliometric data were provided on document type, annual publication number, most productive journals, publication geography, top potential authors, and highly cited articles.The distribution of single words in article titles was analyzed to evaluate the main research focuses and determine their development trends. Word cluster analysis was further performed to detect emerging trends in keloid research. Results: The number of annual articles increased from 24 in 1990 to 63 in 2006 and then increased sharply, reaching 139 in 2019. Dermatologic Surgery published the highest number of articles followed by Plastic and Reconstructive Surgery. The USA ranked top with six publication indicators and China had a dramatic increase in the annual number of articles since 2012. Recent research hotspots include underlying pathogenetic mechanisms, keloid treatment, and therapeutic effect evaluation.Discussion: Keloids remain a research focus. Efforts will be continuously made to understand the underlying mechanism of keloid formation. Despite many treatment modalities, there is no gold standard for keloid treatment, and many efforts are being made in the exploration of new therapies. Moreover, it is foreseeable that objective measurement tools will have a higher status in the assessment of keloids and scars.

show abstract

“…Mitomycin C is a chemotherapeutic agent that is capable of decreasing fibroblast production and cell division by inhibiting transcription of DNA to RNA. It accomplishes this by creating DNA crosslinks [ 2 ]. After excision, gauze soaked with MC at a dose of 1mg/ml is generally applied for 3-5 minutes postoperatively and again at three weeks post-op.…”

Section: Reviewmentioning

confidence: 99%

Keloid Scars: An Updated Review of Combination Therapies

Thornton

García

Hoyer

et al. 2021

Cureus

View full text Add to dashboard Cite

Keloid scars are a common yet poorly understood complication of wound healing that can cause a diminished quality of life. Currently, there is little agreement amongst the medical community regarding the best treatment modality for keloids. For this reason, we have created an updated review of the most successful combination therapies for keloid scars and compared their efficacy based on rates of recurrence following treatment. Additionally, these combination therapies have been compared with intralesional triamcinolone acetonide corticosteroid (TAC), which is considered the mainstay monotherapy for keloids. All combination therapies included in our review were shown to produce superior outcomes than TAC monotherapy. We have also found that certain combination therapies are known to produce superior results when used in specific anatomic locations. Intralesional TAC plus intralesional cryotherapy appeared to have the most promising results for non-auricular keloids, and the authors suggest considering this as a first-line treatment. Additionally, the use of surgical excision plus compression therapy achieved superior results for auricular keloids and should be considered first-line for keloids in these locations.

show abstract

Keloids: a review of therapeutic management

Cited by 125 publications

References 100 publications

Circular RNA CircCOL5A1 Sponges the MiR-7-5p/Epac1 Axis to Promote the Progression of Keloids Through Regulating PI3K/Akt Signaling Pathway

Circular RNA CircCOL5A1 Sponges the MiR-7-5p/Epac1 Axis to Promote the Progression of Keloids Through Regulating PI3K/Akt Signaling Pathway

Scientific landscape and trend analysis of keloid research: a 30-year bibliometric review

Keloid Scars: An Updated Review of Combination Therapies

Contact Info

Product

Resources

About