Keloids: Etiology, and Management by Excision and Intensive Prophylactic Radiation

A Radiobiological Analysis of Multicenter Data for Postoperative Keloid Radiotherapy

“…Studies were included if the follow-up time to assess recurrence was at least 1 year. Series reporting results of surgery without postoperative radiotherapy were also added to the database to establish a baseline for analyzing the dose response (3,7,(28)(29)(30)(31)(32)(33)(34). Results were tabulated separately for earlobe vs. non-earlobe locations whenever they were reported.…”

“…Despite the negative view of postoperative radiotherapy expressed in the review by Leventhal et al (1), there is a reasonably strong body of literature supporting postoperative radiotherapy for keloids as opposed to surgery alone (7,(28)(29)(30)(31)(32)(33)(34). The German Patterns of Care Study, for instance, is an impressive-sized series that reported only 11.4% keloid recurrences from 880 cases undergoing postoperative radiotherapy (2).…”

Surgery and Perioperative Intralesional Corticosteroid Injection for Treating Earlobe Keloids: A Korean Experience

“…The incidence of keloid formation is difficult to assess as it varies from 4.5% to 16% in the Black and Hispanic populations 4,5 . The incidence of keloid in dark-skinned people is estimated to be 3 to 20 times that of light-skinned people 1,[5][6][7] .…”

Adjuvant Radiation of Bilateral Postauricular Keloids: An Illustration of Technique

“…They tend to be susceptible to high rates of recurrence, 1 persist without regression unlike normal scars, and grow beyond the margins of the original wound. [2][3][4] Pathophysiologic mechanisms are not well understood, but it is hypothesized that there is a failure within the cellular regulation pathway to recognize completion of the healing process.…”