Kelulut honey ameliorates glucocorticoid induced osteoporosis via its antioxidant activity in rats

Kamaruzzaman, Mohd Amir; Thanu, Amardev; Yusof, Mohd Imran; Soelaiman, Ima Nirwana; Ramli, Elvy Suhana Mohd

doi:10.4103/2221-1691.271722

Cited by 15 publications

(11 citation statements)

References 4 publications

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“…199 Kelulut honey also reduced the MDA level and augmented SOD activity in dexamethasone-mediated osteoporotic rats. 199 This observation implies that the antioxidant properties of the honey can prevent osteoblast apoptosis by oxidative stress. 199,200 Several phenolic compounds in honey have been reported contributing to the bone protective effects of honey.…”

Section: Honey and Skeletal Healthmentioning

confidence: 86%

“…198 A recent study found that Kelulut honey at 400 mg/kg reversed the changes in the femoral bones of rats receiving long-term dexamethasone. 199 Bone structural parameters and osteoblast number in the Kelulut honey treated-group were preserved with a lower osteoclast number compared to the non-treated osteoporotic group. 199 Kelulut honey also reduced the MDA level and augmented SOD activity in dexamethasone-mediated osteoporotic rats.…”

Section: Honey and Skeletal Healthmentioning

confidence: 89%

“…199 Bone structural parameters and osteoblast number in the Kelulut honey treated-group were preserved with a lower osteoclast number compared to the non-treated osteoporotic group. 199 Kelulut honey also reduced the MDA level and augmented SOD activity in dexamethasone-mediated osteoporotic rats. 199 This observation implies that the antioxidant properties of the honey can prevent osteoblast apoptosis by oxidative stress.…”

Section: Honey and Skeletal Healthmentioning

confidence: 89%

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Direct and Indirect Effect of Honey as a Functional Food Against Metabolic Syndrome and Its Skeletal Complications

Ramli

Sukalingam

Kamaruzzaman

et al. 2021

DMSO

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Metabolic syndrome (MetS) refers to the simultaneous presence of hypertension, hyperglycemia, dyslipidemia and/or visceral obesity, which predisposes a person to cardiovascular diseases and diabetes. Evidence suggesting the presence of direct and indirect associations between MetS and osteoporosis is growing. Many studies have reported the beneficial effects of polyphenols in alleviating MetS in in vivo and in vitro models through their antioxidant and anti-inflammation actions. This review aims to summarize the effects of honey (based on unifloral and multi-floral nectar sources) on bone metabolism and each component of MetS. A literature search was performed using the PubMed and Scopus databases using specific search strings. Original studies related to components of MetS and bone, and the effects of honey on components of MetS and bone were included. Honey polyphenols could act synergistically in alleviating MetS by preventing oxidative damage and inflammation. Honey intake is shown to reduce blood glucose levels and prevent excessive weight gain. It also improves lipid metabolism by reducing total cholesterol, triglycerides and low-density lipoprotein, as well as increasing high-density lipoprotein. Honey can prevent bone loss by reducing the adverse effects of MetS on bone homeostasis, apart from its direct action on the skeletal system. In conclusion, honey supplementation could be integrated into the management of MetS and MetS-induced bone loss as a preventive and adjunct therapeutic agent.

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Section: Honey and Skeletal Healthmentioning

confidence: 86%

Section: Honey and Skeletal Healthmentioning

confidence: 89%

Section: Honey and Skeletal Healthmentioning

confidence: 89%

See 1 more Smart Citation

Direct and Indirect Effect of Honey as a Functional Food Against Metabolic Syndrome and Its Skeletal Complications

Ramli

Sukalingam

Kamaruzzaman

et al. 2021

DMSO

View full text Add to dashboard Cite

show abstract

“…Kelulut honey has also been demonstrated to have anti-oxidative properties when it ameliorated glucocorticoid-induced osteoporosis via a reduction in lipid peroxidation and increase in SOD [ 11 ]. Kelulut honey supplementation prevented sperm and testicular oxidative damage in streptozotocin-induced diabetic rats by increasing SOD activity and GSH level and decreasing protein carbonyl (PC) and MDA levels in the sperm and testis [ 55 ].…”

Section: Medicinal Properties Of Tualang Gelam and Kelulut Honeysmentioning

confidence: 99%

“…This honey has a slightly sour taste and is more liquid than the other honeys. It possesses antibacterial, antioxidant, and anti-osteoporotic properties due to its high antioxidant properties [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Physicochemical and Medicinal Properties of Tualang, Gelam and Kelulut Honeys: A Comprehensive Review

et al. 2021

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Tualang, Gelam and Kelulut honeys are tropical rainforest honeys reported to have various medicinal properties. Studies related to the medicinal properties and physicochemical characteristics of these honeys are growing extensively and receiving increased attention. This review incorporated and analysed the findings on the biological and physicochemical properties of these honeys. Tualang, Gelam and Kelulut honeys were found to possess a wide variety of biological effects attributed to their physicochemical characteristics. Findings revealed that these honeys have anti-diabetic, anti-obesity, anti-cancer, anti-oxidative, anti-microbial, anti-inflammatory and wound-healing properties and effects on the cardiovascular system, nervous system and reproductive system. The physicochemical properties of these honeys were compared and discussed and results showed that they have high-quality contents and excellent antioxidant sources.

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Anti‐inflammatory, antiosteoporotic, and bone protective effect of hydroxysafflor yellow A against glucocorticoid‐induced osteoporosis in rats

Kuai,

Zheng,

Kumar

et al. 2024

J Biochem & Molecular Tox

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Osteoporosis is a common condition worldwide, affecting millions of people. Women are more commonly affected than men, and the risk increases with age. Inflammatory reaction plays a crucial role in the expansion of osteoporosis. Osteoporosis is characterized by a gradual decline in bone density and bone tissue quality, which increases fragility and raises the risk of fractures. We scrutinized the anti‐osteoporosis effect of hydroxysafflor yellow A (HYA) against glucocorticoid‐induced osteoporosis (GIOP) in rats. In‐silico study was carried out on EGFR receptor (PDBID: 1m17), Estrogen Alpha (PDB id: 2IOG), MTOR (PDB id: 4FA6), RANKL (PDB id: 1S55), and VEGFR2 (PDB id: 1YWN) protein. For this investigation, Sprague‐Dawley (SD) rats were used, and they received an oral dose of HYA (5, 10, and 20 mg/kg, b.w.) along with a subcutaneous injection of dexamethasone (0.1 mg/kg/day) to induce osteoporosis. The biomechanical, bone parameters, antioxidant, cytokines, inflammatory, nutrients, hormones, and urine parameters were estimated. HYA treatment significantly suppressed the body weight and altered the organ weight. HYA treatment remarkably suppressed the level of alkaline phosphatase, acid phosphatase, and improved the level of bone mineral density (total, proximal, mild, and dis). HYA treatment restored the level of calcium (Ca), phosphorus (P), estradiol (E2), and parathyroid hormone near to the normal level. HYA treatment remarkably altered the level of biomechanical parameters, antioxidant, cytokines, urine, and inflammatory parameters. HYA treatment altered the level of osteoprotegerin (OPG), receptor activator of nuclear factor kappa beta (RANKL) and RANKL/OPG ratio. The result clearly showed the anti‐osteoporosis effect of HYA against GIOP‐induced osteoporosis in rats via alteration of antioxidant, cytokines, inflammatory, and bone protective parameters.

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Kelulut honey ameliorates glucocorticoid induced osteoporosis via its antioxidant activity in rats

Cited by 15 publications

References 4 publications

Direct and Indirect Effect of Honey as a Functional Food Against Metabolic Syndrome and Its Skeletal Complications

Direct and Indirect Effect of Honey as a Functional Food Against Metabolic Syndrome and Its Skeletal Complications

Physicochemical and Medicinal Properties of Tualang, Gelam and Kelulut Honeys: A Comprehensive Review

Anti‐inflammatory, antiosteoporotic, and bone protective effect of hydroxysafflor yellow A against glucocorticoid‐induced osteoporosis in rats

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