The compliance matrix for a general anisotropic material is usually expressed in an arbitrarily chosen coordinate system, which brings some confusion or inconvenience in identifying independent elastic material constants and comparing elastic properties between different materials. In this paper, a unique stiffest orientation-based standardized compliance matrix is established, and 18 independent elastic material constants are clearly shown. During the searching process for the stiffest orientation, it is interesting to find from our theoretical analysis and an example that a material with isotropic tensile stiffness does not definitely possess isotropic elasticity. Therefore, the ratio between the maximum and minimum tensile stiffnesses, although widely used, is not a correct measure of anisotropy degree. Alternatively, a simple and correct measure of anisotropy degree based on the maximum shear-extension coupling coefficient in all orientations is proposed. However, for a two-dimensional constitutive relation, both the stiffness ratio and the shear-extension coupling coefficient can be adopted as proper measures of anisotropy degree.