Kemadrin in Postencephalitic Parkinsonism

The Pharmacological Properties of the Optical Isomers of Benzhexol, Procyclidine, Tricyclamol and Related Compounds

“…The powerful peripheral atropine-like (" antimuscarinic ") actions of benzhexol, procyclidine, and its quaternary derivative tricyclamol, are described by Cunningham, Harned, Clark, Cosgrove, Daugherty, Hine, Vessey, and Yuda (1949), Montuschi, Phillips, Prescott, and Green (1952) and Lee, Gibson, Dinwiddie, and Mills (1954) respectively. The atropine-like properties of related quaternary aminocyclohexyl-carbinols have also been mentioned (see Adamson, Barrett, and Wilkinson, 1951).…”

A New Anti‐tremor Compound

“…Techniques and tests for the objective measurement of response to treatment in Parkinsonian patients have been devised (Schwab and Prichard 1951), but have been used in few clinical trials. As has been pointed out (Montuschi et al 1952), the results of objective tests can be very misleading, because the patient's performance depends on such factors as his mood, the degree of training and of mental concentration, and his attitude to the observer, and these may vary from day to day.…”

Parkinsonism and the use of Tranquilizers

“…for Diethazine (41) and 60 mg./kg. for Procyclidine (32). The LD 50 by oral administration for Diethazine is 450 mg./kg.…”