Keratin 17 activates AKT signalling and induces epithelial-mesenchymal transition in oesophageal squamous cell carcinoma

Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis

“…Two programs were associated with epithelial differentiation (Epi1/2). The Epi1 program was characterized by the expression of stress keratins ( KRT6 , KRT16 , and KRT17 ) that are associated with keratinocyte hyperproliferation and therefore may play a role in enhancing tumorigenesis and tumor growth 35 – 37 . Epi1 cells displayed upregulation of pathways involved in cell growth and proliferation, such as mTORC1 signaling and PI3K/AKT/mTOR signaling pathways, as well as metabolic pathways including oxidative phosphorylation and glycolysis.…”

Keratin 17 knockdown suppressed malignancy and cisplatin tolerance of bladder cancer cells, as well as the activation of AKT and ERK pathway

“…However, a recent in vitro and in vivo study on osteosarcoma cells have shown that KRT17 participates in the regulation of the AKT/mTOR/HIFα pathway [32]. Besides, the pro-tumor effect of KRT17 was found to be AKT-dependent in gastric cancer [33], as well as in esophageal squamous cell carcinoma [34]. The inconsistences between the reported studies may be caused by the underlying cell type specificity in various types of tumor.…”

Identification of MIRNA-MRNA-HUB Gene Network Prediction in Squamous Cell Lung Carcinoma Via Starbase Server and Insilico Analysis of Hub Genes

“…KRT17 played the role for biological process and cell division whereas perceived in the various condition of tumour progression which AKT or mTOR pathway involved in normal and cancerous. It works as growth regulation for contributed to cell cycle progression, prognosis, proliferation, and tumor development [20][21] . The phosphorylation activated the AKT in Thy308, then Ser473 added EMT for migrates the activity cancer exacerbation and increases the mesenchymal properties [21][22].It was a marker of basal cell differentiation in complex epithelia and analytical of a certain type of epithelial 'stem cells' that acts as a promoter of epithelial proliferation.…”

“…It works as growth regulation for contributed to cell cycle progression, prognosis, proliferation, and tumor development [20][21] . The phosphorylation activated the AKT in Thy308, then Ser473 added EMT for migrates the activity cancer exacerbation and increases the mesenchymal properties [21][22].It was a marker of basal cell differentiation in complex epithelia and analytical of a certain type of epithelial 'stem cells' that acts as a promoter of epithelial proliferation. It also act with psoriasis immunopathogenesis for assured peptide regions regulator of skin immune response and autoantigen.…”