Keratin- and VEGF-Incorporated Honey-Based Sponge–Nanofiber Dressing: An Ideal Construct for Wound Healing

Tavakoli, Mohamadreza; Mirhaj, Marjan; Varshosaz, Jaleh; Al-Musawi, Mastafa H.; Almajidi, Yasir Q.; Danesh Pajooh, Amir Mohammad; Shahriari-Khalaji, Mina; Sharifianjazi, Fariborz; Alizadeh, Mansoor; Labbaf, Sheyda; Shahrebabaki, Kimia Eslami; Nasab, Pegah Madani; Firuzeh, Mahboubeh; Esfahani, Salar Nasr

doi:10.1021/acsami.3c11093

Cited by 20 publications

(2 citation statements)

References 63 publications

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“…On the other hand, this demonstrates that IL-17 is an essential component in the process of facilitating wound repair. VEGF is one of these factors that can stimulate vascular healing following the creation of a wound [ 65 ]. On the other hand, CXCL1 has a significant role in the recruitment of neutrophils that secrete MMP-9, which continues to be beneficial for the improvement of wound repair [ 66 ].…”

Section: Il-17 Familymentioning

confidence: 99%

IL-17 in wound repair: bridging acute and chronic responses

Mu,

Gu,

Tang

et al. 2024

Cell Commun Signal

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Chronic wounds, resulting from persistent inflammation, can trigger a cascade of detrimental effects including exacerbating inflammatory cytokines, compromised blood circulation at the wound site, elevation of white blood cell count, increased reactive oxygen species, and the potential risk of bacterial infection. The interleukin-17 (IL-17) signaling pathway, which plays a crucial role in regulating immune responses, has been identified as a promising target for treating inflammatory skin diseases. This review aims to delve deeper into the potential pathological role and molecular mechanisms of the IL-17 family and its pathways in wound repair. The intricate interactions between IL-17 and other cytokines will be discussed in detail, along with the activation of various signaling pathways, to provide a comprehensive understanding of IL-17’s involvement in chronic wound inflammation and repair.

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Section: Il-17 Familymentioning

confidence: 99%

IL-17 in wound repair: bridging acute and chronic responses

Mu,

Gu,

Tang

et al. 2024

Cell Commun Signal

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“…Electrospun nanofibrous mats of biodegradable protein polymers are widely studied for wound healing because of their high fiber surface, biocompatibility, biodegradability, and fibroblast cell viability area that allows cell binding, such as composites of electrospun gelatin/human hair keratin, cellulose/pectin/soy protein/pomegranate peel extract, keratin/VEGF-incorporated honey, and poly(vinyl alcohol) (PVA)/graphene oxide, and ZnO-incorporated silk fibroin, etc. Thymol, curcumin, and Ag nanoparticles, have been extensively studied as an antibiotic agent to provide antibacterial activity to the electrospun nanofibrous membranes.…”

Section: Introductionmentioning

confidence: 99%

Wound Dressing Based on Silver Nanoparticle Embedded Wool Keratin Electrospun Nanofibers Deposited on Cotton Fabric: Preparation, Characterization, Antimicrobial Activity, and Cytocompatibility

Hassan,

Heins,

Zheng

2024

ACS Appl. Bio Mater.

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Wool keratin (WK) protein is attractive for wound dressing and biomedical applications due to its excellent biodegradability, cytocompatibility, and wound-healing properties. In this work, WK-based wound dressings were prepared by depositing WK/poly(vinyl alcohol) (PVA) and silver nanoparticle (Ag NP)-embedded WK/PVA composite nanofibrous membranes on cotton fabrics by electrospinning. Ag NPs were biosynthesized by reduction and stabilization with sodium alginate. The formed Ag NPs were characterized by ultraviolet–visible and Fourier transform infrared (FTIR) spectroscopy, and their size was determined by transmission electron microscopy and image analysis. The formed Ag NPs were spherical and had an average diameter of 9.95 nm. The produced Ag NP-embedded WK/PVA composite nanofiber-deposited cotton fabric surface was characterized by FTIR and dynamic contact angle measurements, and the nanofiber morphologies were characterized by scanning electron microscopy. The average diameter of the nanofibers formed by 0.1% Ag NP-embedded WK/PVA solution was 146.7 nm. The antibacterial activity of the surface of cotton fabrics coated with electrospun composite nanofibers was evaluated against the two most common wound-causing pathogens, Staphylococcus aureus and Pseudomonas aeruginosa. The cotton fabric coated with 0.1% Ag NP-embedded WK/PVA nanofibers showed very good antibacterial activity against both pathogens, and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay results showed good cytocompatibility against L-929 mouse fibroblast cells. However, the increase in Ag NP content in the nanofibers to 0.2% negatively affected the cell viability due to the high release rate of Ag ions. The results achieved show that the developed wound dressing has good potential for wound healing applications.

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Multitasking Asynchronous Collaborative Nanosystem for Diabetic Wound Healing Based on Hypoglycemic, Antimicrobial, and Angiogenesis‐Promoting Effects

Ren,

Wang,

Gao

et al. 2024

Adv Healthcare Materials

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A diabetic foot ulcer (DFU) is a common and serious complication of diabetes. This complication can result in amputation and death because of the several challenges associated with wound healing that can be attributed to the complex wound microenvironment, including biofilm infection, hyperglycemia, and diabetic angiopathy. Existing investigations on the wound‐healing rate consider only one or two pathogenic factors, and therefore, despite the extensive research on these pathological microenvironments, there is an urgent need to optimize the wound‐healing rate in patients with diabetic foot ulcers. To this end, a multitasking asynchronous collaborative nanosystem is designed in this study. The designed nanosystem can efficiently clear biofilm infections using optimized photodynamic therapy based on a poly photosensitizer ionic liquid (i.e., Ce6IL), reduce local blood glucose concentration using glucose oxidase, and reconstruct blood vessels by stimulating endothelial cell proliferation and migration using nitric oxide. The experimental results indicate that the three‐step sequential collaboration strategy for clearing biofilm infections, reducing glucose concentrations, and reconstructing damaged blood vessels can help significantly accelerate wound healing rate in patients with diabetic foot ulcers.

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Keratin- and VEGF-Incorporated Honey-Based Sponge–Nanofiber Dressing: An Ideal Construct for Wound Healing

Cited by 20 publications

References 63 publications

IL-17 in wound repair: bridging acute and chronic responses

IL-17 in wound repair: bridging acute and chronic responses

Wound Dressing Based on Silver Nanoparticle Embedded Wool Keratin Electrospun Nanofibers Deposited on Cotton Fabric: Preparation, Characterization, Antimicrobial Activity, and Cytocompatibility

Multitasking Asynchronous Collaborative Nanosystem for Diabetic Wound Healing Based on Hypoglycemic, Antimicrobial, and Angiogenesis‐Promoting Effects

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