Keratin coated titanium as an aid to osseointegration: Physicochemical and mechanical properties

Ranjit, Eliza; Hamlet, Stephen; Love, Robert M.

doi:10.1016/j.surfcoat.2023.129457

Cited by 8 publications

(8 citation statements)

References 48 publications

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“…It is unlikely however that the difference in initial proliferation of MG-63 cells observed on the Ti-KC surface in this study could be attributed to surface roughness, as both of the keratin-coated surfaces (i.e. Ti-KC and Ti-KF) exhibited a similar Ra value (0.43 µm and 0.46 µm respectively c.f 0.28 µm for untreated titanium) [20]. This suggests potential for other surface properties to play important roles in cell-biomaterial interactions influencing cellular responses.…”

Section: Discussionmentioning

confidence: 64%

“…Commercially pure (99%) titanium grade IV discs (in vitro studies-10 mm diameter x 2 mm thick, in vivo studies-5 mm diameter x 1 mm thick, Huizhou Boguan Vaccum Applied Materials Co., Ltd, China) were coated with keratin (99.9% pure, Keraplast Manufacturing, New Zealand) via solvent casting and molecular grafting, as described previously [20].…”

Section: Keratin Coated Titaniummentioning

confidence: 99%

“…Details of the surface characteristics of the titanium surfaces coated with wool keratin using APTES as the silane agent and glutaraldehyde as the cross-linking agent have been previously reported [20]. Briefly, the solvent cast titanium surface (Ti-KC) exhibited a thick continuous keratin coating while the molecular grafted titanium surface (Ti-KF) had a thinner, non-uniform keratin coating over the titanium surface.…”

Section: Keratin-coated Titaniummentioning

confidence: 99%

“…Both coated titanium surfaces were chemically stable over 28 d, with the solvent cast titanium surface (Ti-KC) exhibiting good adhesion and tensile bond strength of the coated keratin [20].…”

Section: Keratin-coated Titaniummentioning

confidence: 99%

“…In this regard, our previous studies have described the preparation and physical properties of two keratin-coated titanium surfaces [20]. This study aimed to first characterise the response of osteoblastic MG-63 cells to culture on these keratin-coated titanium surfaces in vitro, followed by a pilot in vivo preclinical study in rodents to assess their effect on bone healing of an intraosseous calvaria defect.…”

Section: Introductionmentioning

confidence: 99%

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The effects of keratin-coated titanium on osteoblast function and bone regeneration

Ranjit,

Hamlet,

Shelper

et al. 2024

Biomed. Mater.

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Introduction: Wool derived keratin, due to its demonstrated ability to promote bone formation, has been suggested as a potential bioactive material for implant surfaces. The aim of this study was to assess the effects of keratin-coated titanium on osteoblast function in vitro and bone healing in vivo.Methods: Keratin-coated titanium surfaces were fabricated via solvent casting and molecular grafting. The effect of these surfaces on the attachment, osteogenic gene, and osteogenic protein expression of MG-63 osteoblast-like cells were quantified in vitro. The effect of these keratin-modified surfaces on bone healing over three weeks using an intraosseous calvaria defect was assessed in rodents.Results: Keratin coating did not affect MG-63 proliferation or viability, but enhanced osteopontin, osteocalcin and bone morphogenetic expression in vitro. Histological analysis of recovered calvaria specimens showed osseous defects covered with keratin-coated titanium had a higher percentage of new bone area two weeks after implantation compared to that in defects covered with titanium alone.Conclusions: The keratin-coated surfaces were biocompatible and stimulated osteogenic expression in adherent MG-63 osteoblasts. Furthermore, a pilot preclinical study in rodents suggested keratin may stimulate earlier intraosseous calvaria bone healing. 

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Section: Discussionmentioning

confidence: 64%

Section: Keratin Coated Titaniummentioning

confidence: 99%

Section: Keratin-coated Titaniummentioning

confidence: 99%

Section: Keratin-coated Titaniummentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The effects of keratin-coated titanium on osteoblast function and bone regeneration

Ranjit,

Hamlet,

Shelper

et al. 2024

Biomed. Mater.

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Bioinspired Physico‐Chemical Surface Modifications for the Development of Advanced Retentive Systems

Dzinovic,

Clark,

Keyhani

et al. 2024

Adv Materials Technologies

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A major aspiration in advanced materials is to create artificial adhesive surfaces for wearable medical devices to meet the demands of the body's challenging settings and dynamics. For instance, dentures replace missing teeth and operate within the oral cavity, where an interplay between forces, muscles, saliva, and roughness of mucosa undermine their ability to grip oral tissues. Consequently, the lack of effective retentive strategies represents a source of dissatisfaction for denture wearers globally. Nature is rich in examples that employ physical and chemical adhesive strategies to optimize interfacial forces in dry and wet environments. Here, keratin‐coated octopus‐like suction cups are presented at the micro‐ and macroscale to improve the retention of rigid poly(methyl methacrylate). Microtopographies are obtained using two‐photon polymerization and maskless lithography, while denture prototypes with macrotopographies are derived via digital light processing 3D printing. Results suggest that microtopographies and keratin‐coated surfaces sustain higher maximum adhesion stress than the non‐topographical and non‐coated surfaces in moist environments, where retention is typically lacking. Proof‐of‐concept dentures demonstrate higher maximum detachment forces than conventional dentures with and without denture adhesive within dry and wet environments. This interdisciplinary research highlights the potential application of a nature‐inspired physico‐chemical approach in the next generation of complete dentures.

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Biomedical Applications of Green and Sustainable Polymers

Pazarçeviren

2024

Reference Module in Materials Science and Materials Engineering

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Keratin coated titanium as an aid to osseointegration: Physicochemical and mechanical properties

Cited by 8 publications

References 48 publications

The effects of keratin-coated titanium on osteoblast function and bone regeneration

The effects of keratin-coated titanium on osteoblast function and bone regeneration

Bioinspired Physico‐Chemical Surface Modifications for the Development of Advanced Retentive Systems

Biomedical Applications of Green and Sustainable Polymers

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