Keratin/Polylactic acid/graphene oxide composite nanofibers for drug delivery

Schifino, Gioacchino; Gasparini, Claudio; Drudi, Simone; Giannelli, Marta; Sotgiu, Giovanna; Posati, Tamara; Zamboni, R.; Treossi, Emanuele; Maccaferri, Emanuele; Giorgini, Loris; Mazzarro, Raffaello; Morandi, Vittorio; Palermo, Vincenzo; Bertoldo, Monica; Aluigi, Annalisa

doi:10.1016/j.ijpharm.2022.121888

Cited by 16 publications

(18 citation statements)

References 65 publications

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“…Keratin solution alone is difficult to spin, due to its poor viscosity [ 109 ]; as such, it is usually necessary to add polymers or prepare high molecular weight keratin, in order to adjust the viscosity of the spinning fluid. Researchers have investigated the compatibility of keratin with various polymers in co-spinning, and successfully developed various types of keratin-based nanofibrous films [ 110 , 111 ]. Aluigi et al [ 112 ] prepared keratin-based nanofibrous films using a mixture of wool keratin and polyamide (PA6) as the electrospinning stock solution.…”

Section: Preparation Methods Of Keratin-based Biofilmsmentioning

confidence: 99%

Preparation Methods and Functional Characteristics of Regenerated Keratin-Based Biofilms

Wang

Tong

2022

Polymers

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The recycling, development, and application of keratin-containing waste (e.g., hair, wool, feather, and so on) provide an important means to address related environmental pollution and energy shortage issues. The extraction of keratin and the development of keratin-based functional materials are key to solving keratin-containing waste pollution. Keratin-based biofilms are gaining substantial interest due to their excellent characteristics, such as good biocompatibility, high biodegradability, appropriate adsorption, and rich renewable sources, among others. At present, keratin-based biofilms are a good option for various applications, and the development of keratin-based biofilms from keratin-containing waste is considered crucial for sustainable development. In this paper, in order to achieve clean production while maintaining the functional characteristics of natural keratin as much as possible, four important keratin extraction methods—thermal hydrolysis, ultrasonic technology, eco-friendly solvent system, and microbial decomposition—are described, and the characteristics of these four extraction methods are analysed. Next, methods for the preparation of keratin-based biofilms are introduced, including solvent casting, electrospinning, template self-assembly, freeze-drying, and soft lithography methods. Then, the functional properties and application prospects of keratin-based biofilms are discussed. Finally, future research directions related to keratin-based biofilms are proposed. Overall, it can be concluded that the high-value conversion of keratin-containing waste into regenerated keratin-based biofilms has great importance for sustainable development and is highly suggested due to their great potential for use in biomedical materials, optoelectronic devices, and metal ion detection applications. It is hoped that this paper can provide some basic information for the development and application of keratin-based biofilms.

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Section: Preparation Methods Of Keratin-based Biofilmsmentioning

confidence: 99%

Preparation Methods and Functional Characteristics of Regenerated Keratin-Based Biofilms

Wang

Tong

2022

Polymers

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“…Biodegradable polymers acting as functional scaffolds have been critical factors in bone tissue engineering [ 4 , 5 ]. Polylactic acid (PLA) is a kind of aliphatic polyester commonly used in different biomedical fields, including bone and maxillofacial regeneration in the field of tissue engineering scaffolds, because of its good biocompatibility and biodegradability [ 6 , 7 , 8 ].…”

Section: Introductionsmentioning

confidence: 99%

“…Electrospinning technology is a popular and easy method of generating non-woven fibrous materials, by which bioactive materials can be added into a PLA matrix [ 9 , 10 ]. The fibrous membranes with a large surface area, high porosity and similar morphology to an extracellular matrix were formed under a high electric field to realize the rapid prototyping of nanofibers [ 8 , 9 , 10 ]. These are the advantages of electrospinning technology.…”

Section: Introductionsmentioning

confidence: 99%

Graphene Oxide/RhPTH(1-34)/Polylactide Composite Nanofibrous Scaffold for Bone Tissue Engineering

Fei

Yao

Wang

et al. 2023

IJMS

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Polylactide (PLA) is one of the most promising polymers that has been widely used for the repair of damaged tissues due to its biocompatibility and biodegradability. PLA composites with multiple properties, such as mechanical properties and osteogenesis, have been widely investigated. Herein, PLA/graphene oxide (GO)/parathyroid hormone (rhPTH(1-34)) nanofiber membranes were prepared using a solution electrospinning method. The tensile strength of the PLA/GO/rhPTH(1-34) membranes was 2.64 MPa, nearly 110% higher than that of a pure PLA sample (1.26 MPa). The biocompatibility and osteogenic differentiation test demonstrated that the addition of GO did not markedly affect the biocompatibility of PLA, and the alkaline phosphatase activity of PLA/GO/rhPTH(1-34) membranes was about 2.3-times that of PLA. These results imply that the PLA/GO/rhPTH(1-34) composite membrane may be a candidate material for bone tissue engineering.

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“…This goal can be reached by electrospinning, a technique that generates nanofibrous systems that mimic the structural environment of ECM and support the growth of cells in applications such as tissue engineering [ 9 , 10 ] and dental implants [ 5 , 11 ]. In wound dressing, WK-nanofibers could also have applications in producing nanofibers membranes with antibacterial properties [ 12 , 13 ] and drug delivery systems [ 14 , 15 ]. The typical applications of WK-nanofibers have been presented in Figure 2 .…”

Section: Introductionmentioning

confidence: 99%

Wool Keratin Nanofibers for Bioinspired and Sustainable Use in Biomedical Field

Ramírez

Vineis

Cruz‐Maya

et al. 2022

JFB

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Keratin is a biocompatible and biodegradable protein as the main component of wool and animal hair fibers. Keratin-based materials support fibroblasts and osteoblasts growth. Keratin has been extracted by sulphitolysis, a green method (no harmful chemicals) with a yield of 38–45%. Keratin has been processed into nanofibers from its solutions by electrospinning. Electrospinning is a versatile and easy-to-use technique to generate nanofibers. It is an eco-friendly and economical method for the production of randomly and uniaxially oriented polymeric nanofibers. Thanks to their high specific surface area, nanofibers have great potential in the biomedical field. Keratin nanofibers have received significant attention in biomedical applications, such as tissue engineering and cell growth scaffolds, for their biocompatibility and bio-functionality. Accordingly, we propose an extensive overview of recent studies focused on the optimization of keratinbased nanofibers, emphasizing their peculiar functions for cell interactions and the role of additive phases in blends or composite systems to particularize them as a function of specific applications (i.e., antibacterial).

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Keratin/Polylactic acid/graphene oxide composite nanofibers for drug delivery

Cited by 16 publications

References 65 publications

Preparation Methods and Functional Characteristics of Regenerated Keratin-Based Biofilms

Preparation Methods and Functional Characteristics of Regenerated Keratin-Based Biofilms

Graphene Oxide/RhPTH(1-34)/Polylactide Composite Nanofibrous Scaffold for Bone Tissue Engineering

Wool Keratin Nanofibers for Bioinspired and Sustainable Use in Biomedical Field

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