Keratinocytes in Atopic dermatitis: Inflammatory signals

Esche, Clemens; Benedetto, Anna De; Beck, Lisa A.

doi:10.1007/s11882-004-0071-8

Cited by 91 publications

(76 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[38][39][40] Chemokines and cytokines are involved in recruiting innate effector cells and T cells to the skin in addition to regulating keratinocyte functions such as proliferation and differentiation. 41,42 In addition to keratinocytes, the skin has a vast collection of cell types that contribute to innate and adaptive immune functions: tissue-resident phagocytes, antigen-presenting cells (LC and dendritic cells/DC), mast cells, T cells (intraepithelial lymphocytes [IEL] and circulating), and the newly identified innate lymphoid cells (For review see 38,43 ). We will discuss the putative roles of the epidermal TJ network in regulating the skin immune system under homeostatic and pathologic conditions.…”

Section: Epidermal Tjs and Immunological Barriersmentioning

confidence: 99%

Epidermal tight junctions in health and disease

et al. 2014

View full text Add to dashboard Cite

Section: Epidermal Tjs and Immunological Barriersmentioning

confidence: 99%

Epidermal tight junctions in health and disease

et al. 2014

View full text Add to dashboard Cite

“…The study of congenital epidermal barrier disorders will help to elucidate the pathways necessary to establish the barrier and also hints at the existence of a complex molecular redundancy that is evoked to repair a disrupted barrier. Although these severe congenital defects are rare, impaired epidermal barrier function is a hallmark feature of 2 of the most common inflammatory skin disorders, psoriasis and AD (43)(44)(45)(46). Psoriasis is a chronic skin disease in which very distinct erythrosquamous silvery scales cover either areas of inflection, the trunk and proximal extremities, or the entire body.…”

Section: Impaired Barrier and Skin Inflammatory Disorders: Atopic Dermentioning

confidence: 99%

Epidermal barrier formation and recovery in skin disorders

Segre¹

2006

Journal of Clinical Investigation

431

357

View full text Add to dashboard Cite

Skin is at the interface between the complex physiology of the body and the external, often hostile, environment, and the semipermeable epidermal barrier prevents both the escape of moisture and the entry of infectious or toxic substances. Newborns with rare congenital barrier defects underscore the skin's essential role in a terrestrial environment and demonstrate the compensatory responses evoked ex utero to reestablish a barrier. Common inflammatory skin disorders such as atopic dermatitis and psoriasis exhibit decreased barrier function, and recent studies suggest that the complex response of epidermal cells to barrier disruption may aggravate, maintain, or even initiate such conditions. Either aiding barrier reestablishment or dampening the epidermal stress response may improve the treatment of these disorders. This Review discusses the molecular regulation of the epidermal barrier as well as causes and potential treatments for defects of barrier formation and proposes that medical management of barrier disruption may positively affect the course of common skin disorders.

show abstract

“…Recent evidence has suggested an important role of skin epithelium, composed mainly of keratinocytes, in the pathogenesis of AD (2). In response to danger signals (e.g., physical injury, microbial products, or allergens), keratinocytes secrete a variety of proinflammatory mediators, which regulate innate and adaptive immune reactions (3).…”

mentioning

confidence: 99%

TSLP acts on infiltrating effector T cells to drive allergic skin inflammation

Oyoshi²,

Garibyan³

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

233

223

View full text Add to dashboard Cite

Thymic stromal lymphopoietin (TSLP) is a cytokine expressed by epithelial cells, including keratinocytes, and is important in allergic inflammation. Allergic skin inflammation elicited by epicutaneous immunization of mice with ovalbumin (OVA), a potential model of atopic dermatitis, was severely impaired in TSLPR ؊/؊ mice, as evidenced by decreased infiltration of eosinophils and decreased local expression of T helper 2 (Th2) cytokines. However, secretion of Th2 cytokines by splenocytes from epicutaneous sensitized TSLPR ؊/؊ mice in response to OVA was normal. Skin dendritic cells from TSLPR ؊/؊ mice were normal in their ability to migrate to draining lymph nodes, express activation markers, and induce proliferation and Th2 cytokine production by naïve T cells. CD4 ؉ T cells from TSLPR ؊/؊ mice expressed the skin homing receptor E-selectin ligand normally, and homed to the skin normally, but failed to transfer allergic skin inflammation to WT recipients. TSLP enhanced Th2 cytokine secretion in vitro by targeting TSLPR on antigen specific T cells. Intradermal injection of anti-TSLP blocked the development of allergic skin inflammation after cutaneous antigen challenge of OVA immunized WT mice. These findings suggest that TSLP is essential for antigen driven Th2 cytokine secretion by skin infiltrating effector T cells and could be a therapeutic target in allergic skin inflammation.

show abstract

Keratinocytes in Atopic dermatitis: Inflammatory signals

Cited by 91 publications

References 48 publications

Epidermal tight junctions in health and disease

Epidermal tight junctions in health and disease

Epidermal barrier formation and recovery in skin disorders

TSLP acts on infiltrating effector T cells to drive allergic skin inflammation

Contact Info

Product

Resources

About