Keratitis by a rare pathogen Colletotrichum gloeosporioides : A case report

Pote, Satish T.; Chakraborty, A.; Lahiri, KK; Patole, Milind S.; Deshmukh, Ranjana; Shah, Shilpa

doi:10.1016/j.mycmed.2017.04.009

Cited by 9 publications

(15 citation statements)

References 14 publications

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“…Five of our seven patients had trauma history, which agrees with findings in previous reports that ocular trauma was the primary risk factor for Colletotrichum keratitis . Because the conidia of Colletotrichum are not freely released, the traumatic implantation is essential for initiation of the infection .…”

Section: Discussionsupporting

confidence: 90%

“…Among the known species of Colletotrichum , C. dematium is the most reported pathogen for keratitis, followed by C. gloeosporioides and C. truncatum. In our study, all seven isolates belonged to two species complexes: C. truncatum and C. gloeosporioides and no C. dematium .…”

Section: Discussionmentioning

confidence: 99%

“…Colletotrichum spp. has been recognised as a rare cause of human infections in recent years, it can cause cutaneous mycosis, arthritis, endophthalmitis, and keratitis . Cases of Colletotrichum keratitis, an infrequent cause of fungal keratitis, are mostly documented in case reports and small series.…”

Section: Introductionmentioning

confidence: 99%

“…Species implicated in keratitis include C. dematium , C. coccodes, C. gloeosporioides , C. graminicola , C. crassipes, C. truncatum, and a Colletotrichum isolate without identification to species level . Only a few studies have diagnosed Colletotrichum keratitis based on nucleic acid sequence analyses, mainly sequencing the internal transcribed spacer (ITS) regions of ribosomal DNA . However, along with the application of molecular methods in fungal taxonomy, several new species of Colletotrichum are described based on not only their morphological characters, but also their molecular signatures.…”

Section: Introductionmentioning

confidence: 99%

“…2,8,9 Cases of Colletotrichum keratitis, an infrequent cause of fungal keratitis, are mostly documented in case reports and small series. Species implicated in keratitis include C. dematium, [10][11][12][13][14] C. coccodes, 13,15,16 C. gloeosporioides, 9,[17][18][19][20] C. graminicola, 21,22 C. crassipes, 13 C. truncatum, 2,4,8 and a Colletotrichum isolate without identification to species level. [23][24][25] Only a few studies have diagnosed Colletotrichum keratitis based on nucleic acid sequence analyses, mainly sequencing the internal transcribed spacer (ITS) regions of ribosomal DNA.…”

Section: Introductionmentioning

confidence: 99%

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Colletotrichum keratitis: A rare yet important fungal infection of human eyes

Hung

Hsiao

Yang

et al. 2020

Mycoses

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Summary Background Colletotrichum is a rare cause of human infection. Previous reports about Colletotrichum keratitis were limited, and most diagnoses from past reports were based on morphological distinction, which could have led to underestimation of the prevalence of Colletotrichum species. Objective We reported phylogenetic analysis, clinical feature and treatment outcome of molecularly diagnosed Colletotrichum keratitis in our hospital. Patients/Methods We recruited 65 patients with culture‐proven filamentous fungal keratitis between January 1, 2015 and December 30, 2018. Through molecular sequencing including internal transcribed spacer (ITS) and multi‐locus phylogenetic analysis of fungal DNA, seven patients were verified as infected with Colletotrichum species, and their medical records were reviewed to determine the clinical characteristics. Results Six of seven patients had predisposing factors including trauma (5) and immunosuppressive status (1). Six isolates were initially misidentified as other fungi through morphological identification. ITS sequencing identified the isolates belonged to two species complex (SC): C. truncatum and C. gloeosporioides; multi‐locus phylogenetic analysis enabled species identification including C. tropicale (3), C. fructicola (2), C. truncatum (1) and C. fusiforme (1). Five patients with C. gloeosporioides SC responded well to medical treatment and two patients with C truncatum SC underwent evisceration because of either no visual potential or intractable pain. Conclusions The molecular approach provides accurate diagnosis and raises epidemiological awareness of Colletotrichum keratitis. Through multi‐locus phylogenetic analysis, we report the human infections caused by C. tropicale, C. fructicola and C. fusiforme. We also highlight the different clinical outcomes between C. gloeosporioides SC and C. truncatum SC.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%