Keratitis due to Lasiodiplodia theobromae successfully treated with voriconazole: A case series from Assam

Konwar, Chaitali; Gogoi, Tapan; Chakraborty, Abhishikta; Nimje, Vivek; Gogoi, Navonil; Nath, Reema

doi:10.1016/j.ijmmb.2024.100558

Cited by 2 publications

References 18 publications

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Favorable outcome of Lasiodiplodia theobromae keratomycosis : a clinical case and systematic review

Lazrak,

Desbois,

Bonnafous

et al. 2024

BMC Ophthalmol

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Backroud Keratitis caused by Lasiodiplodia theobromae is rare and typically associated with a poor prognosis. Current literature lacks sufficient evidence on effective management of patients with this condition. Case presentation A 74-year-old former agricultural worker presented with a red right eye, discomfort, and decreased visual acuity, progressing over three days without treatment. Examination revealed type 2 diabetes and a non-perforating, spiculated corneal abscess with a hypopyon in the right eye. Initial treatment included a triple antibiotic therapy and supportive care. Direct mycological examination identified numerous septate mycelial filaments. Antifungal treatment with natamycin and voriconazole, both topically and orally, was initiated. Cultures confirmed Lasiodiplodia theobromae. The patient showed significant improvement. Treatment continued for eight weeks, with a final visual acuity of 20/50 due to a stromal scar. Conclusion An extensive literature review conducted in November 2023, using databases such as PubMed and Google Scholar with the keywords “lasiodiplodia” and “keratitis” yielded no previous cases of this specific condition being managed solely with the combined use of natamycin and voriconazole. This antifungal combination is commonly included in most management protocols for fungal keratitis. Factors such as the use of corticosteroids and delayed diagnosis were noted to adversely affect the prognosis. This case and this systematic review underscores the potential for non-surgical management options in severe fungal keratitis.

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Favorable outcome of Lasiodiplodia theobromae keratomycosis : a clinical case and systematic review

Lazrak,

Desbois,

Bonnafous

et al. 2024

BMC Ophthalmol

View full text Add to dashboard Cite

show abstract

Favorable outcome of Lasiodiplodia theobromae keratomycosis : a clinical case and systematic review.

Lazrak,

Desbois,

Bonnafous

et al. 2024

Preprint

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Backroud: Keratitis caused by Lasiodiplodia theobromae is rare and typically associated with a poor prognosis. Current literature lacks sufficient evidence on effective management of patients with this condition. Case presentation: A 74-year-old former agricultural worker presented with a red right eye, discomfort, and decreased visual acuity, progressing over three days without treatment. Examination revealed type 2 diabetes and a non-perforating, spiculated corneal abscess with a hypopyon in the right eye. Initial treatment included a triple antibiotic therapy and supportive care. Direct mycological examination identified numerous septate mycelial filaments. Antifungal treatment with natamycin and voriconazole, both topically and orally, was initiated. Cultures confirmed Lasiodiplodia theobromae. The patient showed significant improvement. Treatment continued for eight weeks, with a final visual acuity of 20/50 due to a stromal scar. Conclusion An extensive literature review conducted in November 2023, using databases such as PubMed and Google Scholar with the keywords "lasiodiplodia” and “keratitis" yielded no previous cases of this specific condition being managed solely with the combined use of natamycin and voriconazole. This antifungal combination is commonly included in most management protocols for fungal keratitis. Factors such as the use of corticosteroids and delayed diagnosis were noted to adversely affect the prognosis. This case and this systematic review underscores the potential for non-surgical management options in severe fungal keratitis.

show abstract

Keratitis due to Lasiodiplodia theobromae successfully treated with voriconazole: A case series from Assam

Cited by 2 publications

References 18 publications

Favorable outcome of Lasiodiplodia theobromae keratomycosis : a clinical case and systematic review

Favorable outcome of Lasiodiplodia theobromae keratomycosis : a clinical case and systematic review

Favorable outcome of Lasiodiplodia theobromae keratomycosis : a clinical case and systematic review.

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