Keratoacanthoma Centrifugum Marginatum (KCM) after photodynamic therapy with good response to oral retinoids and topical 5‐fluorouracil

Silva, Esmeralda; Estébanez, Andrea; Martín, J.M.; Monteagudo, Carlos; Montesinos, E.

doi:10.1111/dth.12988

Cited by 5 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several authors reported successful treatment with oral retinoids for KCM. In English‐based literature, to date, nine cases (including our patient) had good therapeutic response to retinoids, either etretinate, acitretin or isotretinoin, dose ranging from 0.5 to 1 mg/kg body weight 5,7‐12 . Our patient had a good and prompt response to acitretin.…”

Section: Discussionmentioning

confidence: 64%

Keratoacanthoma centrifugum marginatum associated with mechanical trauma: Response to acitretin—A case report and review of the literature

Gavrić¹,

Lekić²,

Srećković

et al. 2020

Dermatologic Therapy

View full text Add to dashboard Cite

Keratoacanthoma centrifugum marginatum (KCM) is a very rare variant of keratoacanthoma, characterized with progressive centrifugal growth, central healing, and atrophy. Due to its rarity and lack of distinctive histopathological features, KCM often raises diagnostic and therapeutic challenge. We present a case of a 76‐year‐old Caucasian woman with a single large tumor on her right shin that responded to oral retinoids. The patient presented history of local trauma. The tumor developed over the course of 20 months from a scar. To the best of our knowledge, this is the fifth case of KCM associated with mechanical trauma as a possible triggering factor.

show abstract

Section: Discussionmentioning

confidence: 64%

Keratoacanthoma centrifugum marginatum associated with mechanical trauma: Response to acitretin—A case report and review of the literature

Gavrić¹,

Lekić²,

Srećković

et al. 2020

Dermatologic Therapy

View full text Add to dashboard Cite

show abstract

“…Solitary KCMs most commonly present on sunexposed surfaces of the head and neck as well as upper and lower extremities [4,[7][8][9][10]. The sizes of these lesions are variable, with some reports describing marginatum-type lesions as small as 5.0cm×5.0 cm to as large as 20.0cm×14.0cm [9,10].…”

Section: Case Discussionmentioning

confidence: 99%

Keratoacanthoma centrifugum marginatum

Xiao¹,

Hooper²,

Umphress³

et al. 2021

Dermatology Online Journal

View full text Add to dashboard Cite

“…While the cause is unclear, it has been found to be associated with ultraviolet ray exposure, smoking, and history of chemical exposure. In the recent years, cases that developed from photo dynamic therapy (PDT) have been reported (Silva, Estébanez, Martín, Monteagudo, & Montesinos, ). The lesions can be huge, with diameters as large as 20 cm.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of oral retinoids for keratoacanthoma centrifugum marginatum

Mizuta

Takahashi

Mori

et al. 2020

Dermatologic Therapy

View full text Add to dashboard Cite

Keratoacanthoma centrifugum marginatum (KCM) is a rare variant of keratoacanthoma. This condition is difficult to diagnose because of its large size and expansive nature and may be diagnosed as a malignant tumor. There are various treatments such as surgery and oral retinoids; however, limited studies have verified their effectiveness. Here, we report a case of KCM on the anterior chest of a 50‐year‐old woman and evaluate the efficacy of oral retinoids. In this case, oral retinoids were highly effective for KCM treatment. A total of 55 cases of KCM, including 54 previously reported cases, were reviewed, and their clinical characteristics and treatment were examined. In this report, 14 of 16 patients were effectively treated with oral retinoids, resulting in a treatment rate of 87.5%. Furthermore, even low‐to‐medium doses were sufficient for treatment and prevention. KCM can be misdiagnosed as a malignant disease based on its clinical features. Due to its large size and expansive nature, a wide excision may be performed; however, because oral retinoids have a very high response rate, an accurate diagnosis will help avoid an unnecessary wide excision.

show abstract

Keratoacanthoma Centrifugum Marginatum (KCM) after photodynamic therapy with good response to oral retinoids and topical 5‐fluorouracil

Cited by 5 publications

References 13 publications

Keratoacanthoma centrifugum marginatum associated with mechanical trauma: Response to acitretin—A case report and review of the literature

Keratoacanthoma centrifugum marginatum associated with mechanical trauma: Response to acitretin—A case report and review of the literature

Keratoacanthoma centrifugum marginatum

Efficacy of oral retinoids for keratoacanthoma centrifugum marginatum

Contact Info

Product

Resources

About