Keratoacanthoma (KA): An update and review

Kwiek, Bartłomiej; Schwartz, Robert A.

doi:10.1016/j.jaad.2015.11.033

Cited by 199 publications

(215 citation statements)

References 139 publications

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“…KAs are most frequently recognized as a variant of follicular SCC [6]. They have a tendency to develop quickly and clinically present as solitary papules ranging from 0.5 to 2 cm in diameter.…”

Section: Discussionmentioning

confidence: 99%

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Eruptive Keratoacanthomas within a Red Ink Tattoo: A Case Report

Healey¹,

Galbraith²,

Sammour³

et al. 2018

CRCM

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Background: There has been a longstanding debate regarding whether keratoacanthomas (KAs) are neoplastic or reactive/inflammatory lesions. Aim: The aim of this case report is to, within the aforementioned debate, offer support in favor of the potential reactive nature of keratoacanthomas. Case Presentation: A 64-year-old male presented with an eruption of 25 keratoacanthomas within a red ink tattoo. Eruptions were partially resolved over a matter of months, and completely resolved with treatment using oral Acitretin therapy. We believe this to be the third such reported case of eruptive KAs within only the red ink portions of a tattoo. Prior cases involved 2 and 8 KAs each. Discussion: Multiple studies suggest that KAs are neoplastic in nature and very distinct from cutaneous squamous cell carcinoma. Especially interesting is the finding that KAs have increased expression of apoptotic genes; this is particularly notable because of the tendency for these lesions to spontaneously involute. Skin tumorigenesis can occur in predisposed individuals after carcinogen exposure, thus red ink possesses theoretical potential as a carcinogen. KAs could be seen in this case as in fact a reactive neoplasm.

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Section: Discussionmentioning

confidence: 99%

“…Most commonly, however, they are found to be isolated and apparently spontaneous. Rare cases of eruptive lesions are encountered mainly with genetic syndromes [6]. The appearance of eruptive KAs confined to a red ink tattoo is inconsistent with these known syndromes.…”

Section: Discussionmentioning

confidence: 99%

Eruptive Keratoacanthomas within a Red Ink Tattoo: A Case Report

Healey¹,

Galbraith²,

Sammour³

et al. 2018

CRCM

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“…The exact incidence of KA is probably underestimated [2]. It is assumed that KA originates from hair follicle [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…It is assumed that KA originates from hair follicle [3,4]. Multiple KA is a rare entity and can be familial or sporadic [2]. Many options are available to treat keratoacanthoma.…”

Section: Introductionmentioning

confidence: 99%

Multiple Keratoacanthoma Responsive to Acitretin in an Old Man with Depressed Mood

Zarch¹

2017

Foc Sci

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Introduction: Keratoacanthoma (KA) is a common neoplasm and one of variety squamous cell carcinoma (SCC) characterized by rapid growth with potential for tissue damage. Case Presentation: A 64-year-old man presented with hyperkeratotic papules that initially appeared on the dorsum of his hand and slowly progressed to form a large annular plaque along with multiple small keratotic plaques and papules. He was depressed and worried about the appearance and lesions. He had a history of multiple surgery on the lesions that had recurrence and finally the surgeon decided to do extensive excision with flap that had recurrence on the donor and recipient site, too. Treatment with Acitretin was started. Evolution of new lesions had decreased and stable lesions had begun to regress. Conclusions: Although the gold standard for the treatment of keratoacanthoma is surgical excision, oral retinoid can be a good choice for multiple recurrent keratoacanthoma.

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“…KA presents with a solitary, pink or flesh-colored, dome-shaped nodule with a central keratin plug [1,2]. A fully developed lesion shows lipping of the edge of the lesion that overlaps the central keratin-filled crater, giving it a symmetrical appearance [1,2].…”

Section: Introductionmentioning

confidence: 99%

Aberrant DNA Methylation in Keratoacanthoma

Nobeyama

Nakagawa

2016

PLoS ONE

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BackgroundKeratoacanthoma (KA) is a self-limiting epidermal tumor for which histopathological examination sometimes suggests malignancy. Based on inconsistent clinical views, KA can be regarded as both a benign tumor and a variant of squamous cell carcinoma (SCC). Aberrant DNA methylation frequently occurs in malignant tumors but it scarcely occurs in benign tumors. Whether aberrant methylation occurs in KA has not been previously examined.ObjectiveThe aim is to elucidate whether aberrant methylation of CpG islands (CGI) containing a high density of cytosine-guanine dinucleotide (CpG) sites occurs in KA.MethodsFive SCC cell lines, two cultured samples of normal human epidermal keratinocytes (NHEKs), 18 clinical SCC samples, and 21 clinical KA samples were analyzed with Infinium HumanMethylation450 BeadChips, quantitative real-time methylation-specific PCR (RT-MSP) and/or bisulfite sequencing.ResultsGenome-wide analyses of NHEK, KA, and SCC indicated that there was a greater number of aberrantly hypermethylated CGIs in SCC than in KA and there were aberrantly hypermethylated CGIs which are common in both. Among the common hypermethylated CGIs, RT-MSP and bisulfite sequencing targeting CGIs located on CCDC17, PVR, and MAP3K11 gene bodies also showed that methylation levels were significantly higher in KA than in normal epidermis. Statistical analyses suggested that the methylation level of CGI located on PVR in SCC might be correlated to lymph node metastasis (P = 0.013, Mann-Whitney U test) and that the methylation level of CGI in MAP3K11 in KA might be correlated to age (P = 0.031, linear regression analysis).ConclusionAberrant DNA methylation occurs in KA.

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Keratoacanthoma (KA): An update and review

Cited by 199 publications

References 139 publications

Eruptive Keratoacanthomas within a Red Ink Tattoo: A Case Report

Eruptive Keratoacanthomas within a Red Ink Tattoo: A Case Report

Multiple Keratoacanthoma Responsive to Acitretin in an Old Man with Depressed Mood

Aberrant DNA Methylation in Keratoacanthoma

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