Keratoacanthoma of the lip: A case report with emphasis on histogenesis

Kamath, Pooja; Pereira, Treville; Chande, Mayura; Shetty, Subraj

doi:10.4103/jomfp.jomfp_217_16

Cited by 7 publications

(5 citation statements)

References 13 publications

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“…Ramos et al [ 7 ] suggested that the KA growth cycle is similar to the life cycle of hair follicles, hinting at the possibility that KA may be derived from hair follicle cells. Kamath et al [ 3 ] found that KA cells can differentiate into cells similar to those of the outer root sheath of hair follicles, further supporting the possibility that skin KA originates from hair follicles. Since the lip mucosa lacks the hair follicle structure of the skin, lip KA may be derived from other structures of the lip mucosa.…”

Section: Discussionmentioning

confidence: 97%

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Lower lip recurrent keratoacanthoma: A case report

Liu¹,

Liu²,

Wang³

et al. 2022

WJCC

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BACKGROUND This paper introduces a case of recurrent keratoacanthoma (KA). KA is a self-healing disease. Recurrence after surgical resection is rare. In this case, the local application of retinoic acid ointment after the second operation achieved a good prognosis after 2 years of follow-up. CASE SUMMARY A 76-year-old male patient was admitted to the hospital for "lower lip rupture and scab for 3 mo". Treatment: A rectangular incision was made in the healthy tissue about 3 mm outside the periphery of the lower lip mass, and a modified Bernard sliding flap was designed to completely remove the mass. Pathology showed (lower lip) KA. When the patient returned 6 mo after surgery, the middle mucosa of the lower lip had a bulge with a diameter of about 0.5 cm. The boundary was still clear, the surface was ulcerated. A recurrence of lower lip KA was suspected and a fan-shaped incision was performed in the healthy tissue about 5 mm outside the lesion to completely resect. Pathological showed lower lip KA had recurred. Topical application of tretinoin cream was applied once a day for 3 mo. The lower lip wounds were clean at the 2-year postoperative follow-up and the mucosa was normal. CONCLUSION Adjuvant retinoic acid treatment after KA surgical resection can achieve good results.

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Section: Discussionmentioning

confidence: 97%

“…The cause of KA remains unknown. Sunlight exposure and UV radiation accumulation are considered to be the main risk factors for KA[ 3 ]. Related causes include viral infections, especially human papillomavirus[ 2 ], reduced immune function[ 4 ], trauma[ 5 ], and genetic factors[ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Lower lip recurrent keratoacanthoma: A case report

Liu¹,

Liu²,

Wang³

et al. 2022

WJCC

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“…Keratoacanthoma is a self-limiting benign proliferative epithelial lesion that usually presents an initial proliferative phase, followed by a maturation phase and a involutive or stationary phase, that may or may not have spontaneous regression. In contrast, the squamous cell carcinoma, in any localization, is a malignant epithelial neoplasia that does not undergo spontaneous involution [5,9].…”

Section: Discussionmentioning

confidence: 99%

Lip carcinoma mimicking keratoacanthoma: case reports

Lima

Viana

Souto

et al. 2022

RGO, Rev. Gaúch. Odontol.

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Oral amyloidosis is a disease characterized by extracellular and irreversible deposition of amorphous and fibrillar proteins in the oral cavity, being strongly associated with Multiple Myeloma. The objective of this study is to report a case of a 62-year-old woman diagnosed with Multiple Myeloma who, approximately 2 years after starting treatment for the underlying disease, presented a lesion on the lateral border of the tongue with exophytic growth, pinkish color, vascularized, painless, measuring 3cm in its largest diameter. After histopathological analysis through incisional biopsy, a final diagnosis of amyloidosis was obtained. As a local treatment, we opted for complete excision of the lesion. The patient evolved to death due to Multiple Myeloma influenced by the diagnosis of systemic amyloidosis. Oral amyloidosis is usually associated with the systemic presentation of the disease, making it necessary to conduct a thorough investigation of other organs. Its diagnosis is important since the prognosis is directly related and can negatively influence survival rates and treatment of the underlying disease.

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“…They may appear clinically like squamous cell carcinomas, and differentiation arises from histological analysis. The most common treatment modality is complete excision as this allows for histological examination of the lesion in its entirety [33].…”

Section: Keratoacanthomamentioning

confidence: 99%

Actinic cheilitis: guidance on monitoring and management in primary care

Shah,

Feng,

Carey

et al. 2023

J Oral Med Oral Surg

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Actinic cheilitis is an oral potentially malignant disorder caused by UV radiation leading to damage to epithelial keratinocytes of the lips. It predominantly affects the vermillion border of the lower lip. Due to its association with chronic UV exposure, associated risk factors include geographic areas, outdoor occupations, and skin subtypes. A high proportion of lip squamous cell carcinomas arise from actinic cheilitis lesions, with histological examination usually showing a degree of dysplasia. This paper aims to review the existing literature regarding the clinical picture of actinic cheilitis, its prevalence, differential diagnoses, and consensus on management, for the education of the general dental practitioner in identifying and surveillance of this lesion.

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Keratoacanthoma of the lip: A case report with emphasis on histogenesis

Cited by 7 publications

References 13 publications

Lower lip recurrent keratoacanthoma: A case report

Lower lip recurrent keratoacanthoma: A case report

Lip carcinoma mimicking keratoacanthoma: case reports

Actinic cheilitis: guidance on monitoring and management in primary care

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