Keratoameloblastoma of the mandible

Abstract

Keratoameloblastoma is a very rare ameloblastoma variant defined by extensive squamous metaplasia and keratinization. There are 13 previously reported cases in the literature, with a male predilection of 3:1. A 38-year-old male presented with a painless mandibular swelling which had been progressively increasing in size for 18 months. The incisional biopsy was misdiagnosed as basaloid squamous carcinoma. Owing to financial constraints, the patient had mandibular resection a decade after first noticing the growth, during which the clinical course was essentially benign, thus casting doubt on the initial diagnosis. The final histological diagnosis for both the incisional and resection biopsy specimens was keratoameloblastoma.

Miles to Discover in Histological Grading of Odontogenic Tumours

“…Keratoameloblastoma is a heterogenous group of odontogenic neoplasms which exhibit keratin formation in the connective tissue stroma [6]. Such frank keratin formation was absent in the present case.…”

Keratoameloblastoma: a case report and a review of the literature on its radiologic features

“…Reviews and reports in the extant English-language literature discuss only 11 cases. [4][5][6][7][8][9][10][11][12] Prior reports have focused on the histological features of keratoameloblastoma, while little attention has so far been paid to its radiological features.…”

Acanthomatous Ameloblastoma mimicking Carcinoma: A Case Report with Review

“…9 Considering the histologically, keratinization in ameloblastoma is found only in 3 variations: Acanthomatous ameloblastoma, Keratoameloblastoma and Papilliferous ameloblastoma. 10 In acanthomatous ameloblastoma islands of odontogenic epithelium exhibiting peripheral nuclear palisading with reverse polarization and conspicuous central squamous differentiation is seen. Squamous metaplasia such as that seen in acanthomatous ameloblastoma may be attributed to chronic irritation, calculus and oral sepsis (which could be a source of chronic irritation) have been suggested to play a role in etiology of ameloblastoma.…”