Keratoameloblastomatous transformation of a recurrent unicystic ameloblastoma: a novel case raising diagnostic and classification difficulties

Abstract

Keratoameloblastomatous transformation of a recurrent unicystic ameloblastoma: a novel case raising diagnostic and classification difficulties CORRESPONDENCE Pathology (xxxx), xxx(xxx), -Please cite this article as: Ide F et al., Keratoameloblastomatous transformation of a recurrent unicystic ameloblastoma: a novel case raising diagnostic and classification difficulties, Pathology,

Transformation of an odontogenic keratocyst into a solid variant of odontogenic keratocyst/keratoameloblastoma during long‑term follow‑up: A case report

“…Various histopathological features have been reported in cases of KA: i) Simple histology (follicular AB with extensive keratinization); ii) simple histology with OKC-like features; and iii) complex histology (simple histology with OKC-like features, epithelial follicles packed with parakeratin, and epithelial ribbons forming lamellar stacks of parakeratin extruded into the stroma) ( 10 ). The diagnostic differences between KA and SOKC are the stellate reticulum-like appearance of focal areas, subnuclear vacuolization of basal cells and lamellated-type central keratinization, which are characteristic of KA ( 11 ). However, a lesion with histological features resembling those of both SOKC and KA has been reported under the name of SOKC with ameloblastomatous transformation ( 7 ), and SOKC and KA may fall into a similar histological spectrum of odontogenic tumors.…”

“…The recurrent lesion was solid and consisted of OKC, AB with prominent central keratinization, and epithelium with features of both. Recently, the concept of SOKC/KA has been proposed based on the clinicopathological similarity between the two lesions ( 10 , 11 ). In accordance with this concept, the lesion in the present case was diagnosed as originating from OKC and becoming SOKC/KA upon recurrence.…”