Keratocystic odontogenic tumor: a 10-year retrospective study of 83 cases in an Iranian population

Habibi, Ataollah; Saghravanian, Nasrollah; Habibi, Mehdi; Mellati, Ehsan; Habibi, Morteza

doi:10.2334/josnusd.49.229

Cited by 103 publications

(100 citation statements)

References 32 publications

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“…As it is associated with an aggressive characteristic, a high recurrence rate, and based on histological findings, the term was changed to KCOT in the WHO classification in 2005 (Barnes et al 2005;Cakur et al 2008). For a long time, total resection was the only treatment option for KCOT (Habibi et al 2007;González-Alva et al 2008;Grasmuck and Nelson 2010), but complete removal of a large KCOT requires an extensive approach. Some surgeons adopt this conservative approach, which is total resection, for KCOT, whereas marsupialization followed by close follow-up has been proposed by other groups (Nakamura et al 2002;Pogrel and Jordan 2004;Maurette et al 2006;Habibi et al 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Traditionally, the treatment for KCOT has been total resection and extraction of the cyst-associated tooth (Habibi et al 2007;González-Alva et al 2008;Grasmuck and Nelson 2010). The recurrence rate with total resection varies among reports.…”

Section: Introductionmentioning

confidence: 99%

“…Compared to other odontogenic cystic lesions, KCOT has locally destructive characteristics and is associated with a high recurrence rate after surgery (Vered et al 2005;Giuliani et al 2006;Habibi et al 2007;Cakur et al 2008;González-Alva et al 2008;Grasmuck and Nelson 2010).…”

Section: Introductionmentioning

confidence: 99%

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Minimally Invasive Treatment for Hard Palate-Invading Maxillary Keratocystic Odontogenic Tumor

Nomura

Arakawa

Fujishima

et al. 2015

Tohoku J. Exp. Med.

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Keratocystic odontogenic tumor (KCOT) is one of the benign developmental odontogenic cystic lesions arising from impacted teeth. In comparison to other odontogenic cysts, such as radicular cysts and dentigerous cysts, KCOT is known to be more aggressive and is associated with a relatively high recurrence rate. Traditionally, KCOT has been treated with total resection through sublabial incision. Marsupialization is advocated to reduce surgical invasion. However in all the cases, marsupialization was performed in the oral cavity. With the recent development of appropriate instruments and the endoscopic modified medial maxillectomy (EMMM) technique, which allows preservation of the inferior turbinate and nasolacrimal duct, an exclusive endoscopic approach to KCOT becomes possible. However, when the KCOT invades the hard palate, total resection of the tumor requires subtotal maxillectomy including hard palate. Consequently, as the maxillary sinus connects to the oral cavity, life-long use of a prosthesis becomes mandatory. Here we report a case of a seventeen-year-old female with a hard palate-invading KCOT who was successfully treated with the EMMM approach. The KCOT was fenestrated to the nasal cavity, leading to preservation of the hard palate. The lesion invading the hard palate was found to remain unchanged over one year upon follow-up. The trans-nasal approach with EMMM is a direct, minimally invasive method providing a direct field of view for the treatment of maxillary odontogenic cysts. Marsupialization of the KCOT with the EMMM technique might be a viable treatment option if the maxillary KCOT invades surrounding structures.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Minimally Invasive Treatment for Hard Palate-Invading Maxillary Keratocystic Odontogenic Tumor

Nomura

Arakawa

Fujishima

et al. 2015

Tohoku J. Exp. Med.

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“…Habibi et al study on Iranian populations showed that 8.1% of 83 cases with KCOTs, were associated with NBCCS and 7.6% of them had recurrence [21].…”

Section: Minor Criteria [13-15]mentioning

confidence: 99%

Non-Syndromic Multiple Odontogenic Keratocysts: A Case Report and Comparison with Syndromic Multiple Odontogenic Keratocysts

Golgire¹,

Varekar²

2016

J Clin Case Rep

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The Odontogenic Keratocyst (OKC) is a relatively common developmental odontogenic cyst arising from the dental lamina remnants. Multiple OKCs are rare and occur either in syndromic and non-syndromic groups. The Keratocyst demands special consideration because of its aggressive clinical nature and propensity for recurrence. Epithelial proliferation plays a significant role in behaviour of OKC and suggests that more aggressive behaviour is present in case of syndromic OKC than non-syndromic ones. Here we report a case of multiple OKCs in a 20 year old female patient having simultaneous occurrence of cystic lesions in maxilla and mandible without any syndromic manifestations. Comparison between syndromic and non syndromic multiple OKCs is also discussed.

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“…The role of mutation of the PTCH gene in the etiology of KCOTs resulted in reclassification of this lesion as a neoplasm in the WHO classification of head and neck tumors in 2005 and its renaming as KCOT (5). KCOTs often occur in the mandibular ramus and angle region but rarely in other mandibular regions and in the maxillary region (7,8). Radiographically, KCOTs present as well defined radiolucent lesions with smooth and usually corticated margins.…”

Section: Introductionmentioning

confidence: 99%

Keratokistik odontojenik tümör: 64 vakalık retrospektif çalışma

Akay¹,

Tetik²,

Zeytinoğlu³

2015

Ege Tıp Dergisi

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Aim: The purpose of this retrospective study was to evaluate the clinicopathological features of 64 patients with keratocystic odontogenic tumor (KCOT). Materials and Methods:The patients ranged in age at the time of diagnosis from 8 to 74 years (mean: 38.20 ± 16.71). Postoperative follow-up period was 3-8 years (mean time 4.76 ± 1.10). This research was carried out on panoramic radiographs and histopathological samples. Data such as gender, age, treatment methods, location of the tumor, presence of impacted teeth and its histological features were subjected to descriptive statistical analyses with the statistical software program. Results:Of the 64 analyzed cases of KCOT, 68.8% of them were men and 31.2% were females (male-to-female ratio was 2.2:1). It was observed that KCOT peaked in the third and fifth decade of life (23.4%-20.3%). The incidence of KCOT was higher in the mandible than in the maxilla (76.6%-23.4%). There was recurrence in nine out of 64 subjects (14.1%) in the follow-up period. The recurrence was more often found in posterior mandible. It is noteworthy that in 9 recurrent subjects, 7 lesions were parakeratotic and 4 lesions were associated with daughter cysts. Conclusion:Although there are several studies about KCOT in the literature, the choice of treatment modalities remains controversial. In recurrent subjects, more aggressive therapy approaches should be considered. Periodic controls and aggressive treatment approaches may be effective in the prevention of recurrences. (%23.4-%20.3). KOT insidansı mandibulada maksillaya oranla daha yüksekti (% 76.6-% 23.4 Keywords

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Keratocystic odontogenic tumor: a 10-year retrospective study of 83 cases in an Iranian population

Cited by 103 publications

References 32 publications

Minimally Invasive Treatment for Hard Palate-Invading Maxillary Keratocystic Odontogenic Tumor

Minimally Invasive Treatment for Hard Palate-Invading Maxillary Keratocystic Odontogenic Tumor

Non-Syndromic Multiple Odontogenic Keratocysts: A Case Report and Comparison with Syndromic Multiple Odontogenic Keratocysts

Keratokistik odontojenik tümör: 64 vakalık retrospektif çalışma

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