Keratocystic odontogenic tumor: a review

Godhi, Brinda Suhas; Kukreja, Pankaj

doi:10.1007/s12663-009-0031-x

Cited by 24 publications

(17 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present study, showed an intense p53 expression in OKC when compared with ameloblastoma, which lends support to the new nomenclature for this lesion as Keratocystic odontogenic tumour; warranting the need for more aggressive treatment modality such as enucleation with application of carnoy's solution [26].…”

Section: Resultssupporting

confidence: 84%

Classifying odontogenic keratocysts as benign cystic neoplasms: a molecular insight into its aggressiveness

Shetty¹,

Urs²,

Godhi³

et al. 2010

J. Maxillofac. Oral Surg.

View full text Add to dashboard Cite

Objective The present study was conducted with the aim to evaluate the expression of p53 in Odontogenic Keratocyst (OKC) and Ameloblastoma to correlate with the aggressiveness of these lesions. Material and methods Immunohistochemical (IHC) staining was performed using anti-p53 antibody in eighteen cases each of OKC and ameloblastoma. Results p53 positivity was seen in all the cases of OKCs and ameloblastomas. p53 positive cells were seen predominantly in the suprabasal cell layer of OKC and in the peripheral pre-ameloblast like cells in ameloblastoma. Total p53 count was significantly higher in ameloblastoma as compared to OKC. But the intensely stained p53 cell count showed no statistically significant difference between the two lesions. Conclusion The high p53 expression in OKC when compared with ameloblastoma, acknowledges OKC as an aggressive lesion and hence a more aggressive treatment modality is recommended.

show abstract

Section: Resultssupporting

confidence: 84%

Classifying odontogenic keratocysts as benign cystic neoplasms: a molecular insight into its aggressiveness

Shetty¹,

Urs²,

Godhi³

et al. 2010

J. Maxillofac. Oral Surg.

View full text Add to dashboard Cite

show abstract

“…Authors had been shedding light into the importance of careful histological exam in extensive lesions, in order to prevent a poor diagnosis 8 . Thus, a biopsy is the first step in any extended mandibular lesion.…”

Section: Discussionmentioning

confidence: 99%

“…For a while since its first description by Philipsen in 1956 OKC ideal treatment was considered controversial 8 , diverging between conservative and aggressive surgical treatments. Lately, the literature has suggested less invasive interventions 9 .…”

Section: Introductionmentioning

confidence: 99%

Association of Treatment and a 3-D image follow - up on a Recurrent Keratocyst

et al. 2017

View full text Add to dashboard Cite

Introduction: Accordingly to the latest edition of the World Health Organization (WHO) the previously known Keratocyst Odontogenic Tumour (KCOT) has now returned to the simple odontogenic cyst (OKC) classification. We present a case successfully treated by a combination of minimal-invasive approaches. Case Presentation: A large OKC was identified extending from tooth 3.8 through the condylar process in the mandible and staged surgical conservative approaches were performed. Total healing was achieved and followed -up over 8 years. The case was well documented via panoramic radiographs, CBCTs, and a 3D image tool illustrates the cortical bone destruction (before treatment) and the cortical bone healing after treatment. Discussion: Agreement regarding terminology and treatment of OKC has been reached. In this case, a complete healing of a recurrent OKC was achieved by decompression, enucleation, and blurring of the bone walls. Rigorous follow-up enriched by a 3D reconstruction imaging allows an educational view of the healing. Conclusion: This case suggests that a staged surgery approaches concurrent to rigorous patient follow-up could be a feasible alternative to extensive OKT treatment.And, reinforces the importance of collaboration between orthodontist, pathologist, OMS, and the patient have crucial importance in the conservative management of the lesion.

show abstract

“…Different studies show different recurrence rates (2,4,33). Most reports show that recurrence will appear with in 5 to 7 years (12,22,27,29).…”

Section: Discussionmentioning

confidence: 99%

Keratokistik odontojenik tümör: 64 vakalık retrospektif çalışma

Akay¹,

Tetik²,

Zeytinoğlu³

2015

Ege Tıp Dergisi

View full text Add to dashboard Cite

Aim: The purpose of this retrospective study was to evaluate the clinicopathological features of 64 patients with keratocystic odontogenic tumor (KCOT). Materials and Methods:The patients ranged in age at the time of diagnosis from 8 to 74 years (mean: 38.20 ± 16.71). Postoperative follow-up period was 3-8 years (mean time 4.76 ± 1.10). This research was carried out on panoramic radiographs and histopathological samples. Data such as gender, age, treatment methods, location of the tumor, presence of impacted teeth and its histological features were subjected to descriptive statistical analyses with the statistical software program. Results:Of the 64 analyzed cases of KCOT, 68.8% of them were men and 31.2% were females (male-to-female ratio was 2.2:1). It was observed that KCOT peaked in the third and fifth decade of life (23.4%-20.3%). The incidence of KCOT was higher in the mandible than in the maxilla (76.6%-23.4%). There was recurrence in nine out of 64 subjects (14.1%) in the follow-up period. The recurrence was more often found in posterior mandible. It is noteworthy that in 9 recurrent subjects, 7 lesions were parakeratotic and 4 lesions were associated with daughter cysts. Conclusion:Although there are several studies about KCOT in the literature, the choice of treatment modalities remains controversial. In recurrent subjects, more aggressive therapy approaches should be considered. Periodic controls and aggressive treatment approaches may be effective in the prevention of recurrences. (%23.4-%20.3). KOT insidansı mandibulada maksillaya oranla daha yüksekti (% 76.6-% 23.4 Keywords

show abstract

Keratocystic odontogenic tumor: a review

Cited by 24 publications

References 44 publications

Classifying odontogenic keratocysts as benign cystic neoplasms: a molecular insight into its aggressiveness

Classifying odontogenic keratocysts as benign cystic neoplasms: a molecular insight into its aggressiveness

Association of Treatment and a 3-D image follow - up on a Recurrent Keratocyst

Keratokistik odontojenik tümör: 64 vakalık retrospektif çalışma

Contact Info

Product

Resources

About