Keratocystic odontogenic tumor: Case report, treatment review and future diagnostic trends

Bharani, K.S.N. Shiva; Lakshmi, Subha; Kamath, Anuradha; Hammannavar, Reshma

doi:10.1016/j.ajoms.2012.01.011

Cited by 5 publications

(7 citation statements)

References 54 publications

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“…There are pros and cons for all the treatment options. A variety of treatment modalities, ranging from conservative to radical, have been developed in an attempt to definitively treat KCOT [24]. The general approach to treating KCOT is enucleation and curettage, and the alternative therapies of decompression/marsupialization are also valid but have specific limited indication [10].…”

Section: Discussionmentioning

confidence: 99%

“…Aggressive treatment addresses the "neoplastic nature" of KCOT and includes peripheral ostectomy, chemical curettage with Carnoy's solution or en bloc/segmental resection. Excision of the mucosa overlying the lesion has been recommended, based on histological evidence that clusters of epithelial islands and microcysts (presumably with the potential to cause recurrence), found in the area where the lesion was connected with the mucosa [24].…”

Section: Discussionmentioning

confidence: 99%

“…Aggressive surgery/resection is indicated in multiple recurrences, in tumors that cannot be managed by other methods, and in malignant transformation since cases of carcinoma arising from KCOT have been documented [10] [24]. Conversely, cases have been successfully treated by marsupialization alone, and this, in consequence, would deny KCOT of its tumorigenic nature.…”

Section: Discussionmentioning

confidence: 99%

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Odontogenic Keratocyst Tumor: A Case Report and Literature Review

Belmehdi¹,

Chbicheb²,

Wady³

2016

OJST

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First described by Philipsen in 1956, the odontogenic keratocyst is characterized by a large squamous keratinization of its border, an aggressive growth and a high recurrent rate. It is now designated by the World Health Organization as a keratocystic odontogenic tumour (KOT). Clinically, the KOT is manifested by an asymptomatic growth. Radiographically, it appears as a well-defined unilocular or multilocular osteolytic lesion. The diagnostic approach is based on a combined analysis of the medical history, the clinical appearance and the radiographic appearance. The diagnosis may be confirmed by the anatomical pathology report. Finally, treatment consists of surgical excision and follow up is characterized by a high rate of recurrence. The authors report a case of keratocystic odontogenic tumor of the upper jaw and review the various diagnoses, therapeutics and follow up aspects of this type of tumors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Odontogenic Keratocyst Tumor: A Case Report and Literature Review

Belmehdi¹,

Chbicheb²,

Wady³

2016

OJST

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“…Inflammation caused by marsupialization helps change the biologic behavior into a less aggressive form. The existence of greater proliferative activity in the epithelial cells of inflamed odontogenic keratocysts may be associated with the disruption of the typical structure [ 16 , 17 ], and marsupialization changes the cyst epithelium immunohistochemically [ 18 ]. However, marsupialization alone has not been recommended because of unpredictable recurrence rates [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

Deep Neck Space Infection Caused by Keratocystic Odontogenic Tumor

Kim

You

et al. 2014

Maxillofacial Plastic and Reconstructive Surgery

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Keratocystic odontogenic tumor (KCOT) is a benign cystic intraosseous tumor of odontogenic origin. An infection of a KCOT is not common because KCOT is a benign developmental neoplasm. Moreover, a severe deep neck space infection with compromised airway caused by infected KCOT is rare. This report presents a 60-year-old male patient with a severe deep neck space infection related to an infected KCOT due to cortical bone perforation and rupture of the exudate. Treatment of the deep neck space infection and KCOT are reported.

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“…With advances in genetic and molecular research with special reference to PTCH1 mutations and involvement of the Hedgehog signaling pathway a more lucid understanding of the pathogenesis has been realised. It is probable that future treatment strategies will use molecular approaches that may eventually reduce or eliminate the need for aggressive surgical intervention [50].…”

Section: New Avenues In Managementmentioning

confidence: 99%