Keratomykose engl. (Keratomycosis)

Behrens–Baumann, W.

doi:10.1007/978-3-662-60399-4_9

Cited by 2 publications

(19 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In temperate climates, mycotic keratitis occurs more frequently as a result of yeast infections (mainly Candida species, 22-66 % [4]) in the context of immunosuppression (incl. diabetes, HIV/AIDS, steroid therapy) or chronic ocular surface disease (mainly exposure keratopathy, keratoconjunctivitis sicca) [3,8,9,11,12]. Nowadays, however, Fusarium keratitis is by no means to be considered a disease confined to the tropics [1]: Authors from Germany, the United Kingdom, Denmark, the Netherlands, and the USA have described an increase in diseases with Fusarium keratitis in recent years [1,4,5].…”

Section: Epidemiology and Risk Factorsmentioning

confidence: 99%

“…Too superficial sampling then results in a false negative culture [19,23]. Probably also due to this, the sensitivity of the culture detection for Fusarium keratitis is only 50 %; occasionally, culture detection is possible by deep stromal biopsy or anterior chamber sample [1,3]. The culture analysis should be continued for at least 2 weeks, as late positive findings are also possible and relevant for resistance testing [16].…”

Section: Culturementioning

confidence: 99%

“…In contrast to culture, the panfungal PCR assay has a sensitivity of 70-100 % for Fusarium keratitis and is an important tool for confirming the diagnosis, if available [3,4,12]. Differentiation of Fusarium species is also possible based on the TEF-1α (translation elongation factor 1-alpha) region or the RNA polymerase II subunits 1 and 2 (RPB1 and RPB2) [25].…”

Section: Molecular Geneticsmentioning

confidence: 99%

“…Delayed diagnosis and limited access to antifungal therapeutics, surgical treatment options, and donor corneas in the regions above usually lead to significant functional loss and blindness in the affected eye [1,2]. However, for about two decades now [3], an increase in cases of mycotic keratitis, especially due to Fusarium, has been recorded in Europe, including in Germany [1,4,5]. Fusarium, like Aspergillus, belongs to the filamentous fungi and occurs ubiquitously in nature as an opportunistic pathogen.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Die Fusarien-Keratitis auf dem Vormarsch – eine aktuelle klinische Übersicht

Khoramnia,

Augustin,

Kovalchuk

et al. 2023

Klin Monbl Augenheilkd

View full text Add to dashboard Cite

ZusammenfassungDie Keratitis durch Fusarien stellt in Deutschland ein insgesamt seltenes, aber durch seinen raschen Krankheitsverlauf, die meist verspätete Diagnosestellung und die eingeschränkten konservativen Behandlungsoptionen mittels antimykotischer Therapie ein ernst zu nehmendes Krankheitsbild mit potenziell visusbedrohendem Verlauf dar. Durch die zunehmende Anwendung von Kontaktlinsen und möglicherweise durch die veränderten klimatischen Bedingungen ist ein weiterer Anstieg der Fallzahlen in Deutschland zu erwarten. Das rechtzeitige Erkennen und Einleiten der antimykotischen Therapie und bei ausbleibender Besserung die frühzeitige Durchführung einer notfallmäßigen Keratoplastik sind hierbei maßgeblich für den Therapieerfolg.

show abstract

Section: Epidemiology and Risk Factorsmentioning

confidence: 99%

Section: Culturementioning

confidence: 99%

Section: Molecular Geneticsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Die Fusarien-Keratitis auf dem Vormarsch – eine aktuelle klinische Übersicht

Khoramnia,

Augustin,

Kovalchuk

et al. 2023

Klin Monbl Augenheilkd

View full text Add to dashboard Cite

show abstract

“…This is attributed to the increasing use of soft contact lenses, topical steroids, and systemic immunosuppression. Other risk factors include ocular trauma, previous corneal surgery, and ocular surface diseases [3,4]. The diagnosis can be difficult to make, and the findings are not easily distinguishable from other infectious corneal diseases.…”

Section: Introductionmentioning

confidence: 99%

Recurrent Filamentous Fungal Keratitis Caused When the Primarily Selected Graft Diameter was Too Small

Berger

Seitz

Flockerzi

et al. 2022

Klin Monbl Augenheilkd

View full text Add to dashboard Cite

Purpose To establish the importance of using a sufficiently large corneal graft in primary penetrating keratoplasty in order to prevent recurrence of fungal keratitis. Oberservations A 58-year-old female patient underwent emergency penetrating keratoplasty (diameter 7.0 mm, double running suture) for therapy-resistant fungal keratitis (Fusarium solani) at an external eye clinic. Despite intensive antifungal therapy, new fungal infiltrates appeared in the host cornea after a few days. The patient was referred to our department for further treatment. On first presentation, circular infiltrates were seen around the corneal graft with anterior chamber involvement and therapy-resistant hypopyon. We performed an emergency penetrating repeat keratoplasty (diameter of 13.0 mm, 32 interrupted sutures) combined with anterior chamber lavage and intracameral and intrastromal drug injection. Conclusion and Importance Fungal keratitis sometimes has a frustrating clinical course. Therefore, early diagnosis with effective therapy initiation is of the utmost importance. In cases of penetrating keratoplasty, optimal planning and timing (before anterior chamber involvement) should be provided. Sufficient safety distance must be ensured in the choice of graft diameter, fixation with multiple interrupted sutures, and anterior chamber lavage, as well as intracameral and intrastromal drug administration. Incomplete excision carries a risk of recurrence and endophthalmitis in the course. Close postoperative control is necessary to detect early recurrences.

show abstract

Keratomykose engl. (Keratomycosis)

Cited by 2 publications

References 38 publications

Die Fusarien-Keratitis auf dem Vormarsch – eine aktuelle klinische Übersicht

Die Fusarien-Keratitis auf dem Vormarsch – eine aktuelle klinische Übersicht

Recurrent Filamentous Fungal Keratitis Caused When the Primarily Selected Graft Diameter was Too Small

Contact Info

Product

Resources

About