Keratoplasty in Contact Lens Related Acanthamoeba Keratitis

Kettesy, Beáta; Módis, László; Berta, András; Kemény-Beke, Ádám

doi:10.5772/21621

Cited by 3 publications

(2 citation statements)

References 48 publications

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“…Конфокальная микроскопия роговицы in vivo представляет собой быстрый и точный (чувствительность -84-100 %) метод диагностики при подозрении на АК. Метод контактный, неинвазивный, позволяет визуализировать цисты акантамёб в виде округлых высокорефлективных образований, расположенных в слоях эпителия роговицы до средней стромы [8,9,22,23]. При помощи конфокальной микроскопии удаётся выявить и другой важный диагностический признак АК -кератоневрит, имеющий вид утолщённых нервных стволов и белых линий вдоль нервов, обусловленных нейротропностью амёб.…”

Section: диагностикаunclassified

Acanthamoeba keratitis. Review of literature. Case reports

Skryabina

Владимировна²,

Astakhov

et al. 2019

Ophthalmology Reports

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Acanthamoeba keratitis (АК) is a parasitic infectious condition caused by corneal invasion by free-living amoebae. In 86% of cases, AK affects contact lens wearers. Delayed diagnosis and inadequate treatment of this disease leads to development of a severe form of keratouveitis and corneal perforation. Consequently, this group of diseases is one of the causes of visual disability in working-age population.

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Section: диагностикаunclassified

Acanthamoeba keratitis. Review of literature. Case reports

Skryabina

Владимировна²,

Astakhov

et al. 2019

Ophthalmology Reports

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“…It is caused by the ubiquitous free-living pathogenic species of Acanthamoeba [10, 12–15] . Acanthamoeba can be found commonly in soil, air, water, cooling towers, sewage systems, and heating, ventilating, air conditioning (HVAC) systems [16, 17] . Since the first case of Acanthamoeba keratitis reported by Naginton et al .…”

Section: Acanthamoeba Keratitis and Pathogenesismentioning

confidence: 99%

Role of Protease-Activated Receptors 2 (PAR2) in Ocular Infections and Inflammation

Tripathi

Alizadeh

2014

Receptor Clin Invest

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Protease-activated receptors (PARs) belong to a unique family of G protein-coupled receptors (GPCRs) that are cleaved at an activation site within the N-terminal exodomain by a variety of proteinases, essentially of the serine (Ser) proteinase family. After cleavage, the new N-terminal sequence functions as a tethered ligand, which binds intramolecularly to activate the receptor and initiate signaling. Cell signals induced through the activation of PARs appear to play a significant role in innate and adoptive immune responses of the cornea, which is constantly exposed to proteinases under physiological or pathophysiological conditions. Activation of PARs interferes with all aspects of the corneal physiology such as barrier function, transports, innate and adoptive immune responses, and functions of corneal nerves. It is not known whether the proteinase released from the microorganism can activate PARs and triggers the inflammatory responses. The role of PAR2 expressed by the corneal epithelial cells and activation by serine protease released from microorganism is discussed here. Recent evidences suggest that activation of PAR2, by the serine proteinases, play an important role in innate and inflammatory responses of the corneal infection.

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