Keratoprostheses: Advancing toward a true artificial cornea

Hicks, C.R.; Fitton, J. Helen; Chirilă, Traian V.; Crawford, Gemma; Constable, Ian J.

doi:10.1016/s0039-6257(97)00024-6

Cited by 141 publications

(96 citation statements)

References 69 publications

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“…This contrasts with several other published keratoprosthesis series where high incidences of serious complications are noted within the first 6 months. 5 The flexibility of the hydrogel optic allows Corneal replacement using a synthetic hydrogel cornea CR Hicks et al 390…”

Section: Discussionmentioning

confidence: 99%

Corneal replacement using a synthetic hydrogel cornea, AlphaCor™: device, preliminary outcomes and complications

Hicks

Crawford

Lou

et al. 2003

Eye

128

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Section: Discussionmentioning

confidence: 99%

Corneal replacement using a synthetic hydrogel cornea, AlphaCor™: device, preliminary outcomes and complications

Hicks

Crawford

Lou

et al. 2003

Eye

128

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“…[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] Several complications, associations, and risk factors have been identified. [21][22][23][24][25] The indications and surgical techniques have been evolving with experience.…”

Section: Introductionmentioning

confidence: 99%

AlphaCor artificial cornea: clinical outcome

Jirásková

Rozsíval

Burova

et al. 2011

Eye

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Purpose The purpose of this study was to describe the long-term results of AlphaCor implantations, and to evaluate the main complications and risk factors. Methods Retrospective analysis of preoperative and follow-up data from 15 AlphaCor implantations. Analysis of outcomes, trends, and associations was performed and compared with data from published clinical trials and a literature review.Results The survival rate of the device at 1, 2, and 3 years was 87%, 58%, and 42%, respectively. Postoperative visual acuity ranged from hand movement to 0.8. The most significant complications were stromal melt (nine cases), optic deposition (three eyes), and retroprosthetic membrane formation (three eyes). The most common device-unrelated complication was trauma (three patients). All complications were managed without loss of the eye. Conclusion AlphaCor provides a treatment option for patients with corneal blindness in which a donor tissue graft would not succeed.

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“…Corneal transplants are currently the only treatment for restoring vision. Total corneal transplantation has a 90% success rate in patients with good prognoses (low graft vascularization and inflammation), but almost no chance of success in patients with alkali burns or recurrent graft failures (4). The shortcomings of corneal transplantation include significant immune rejection rates (5,6), the possibility of infections (7,8), and donor shortages (7).…”

mentioning

confidence: 99%

The Development of a Tissue-Engineered Cornea: Biomaterials and Culture Methods

et al. 2008

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ABSTRACT:The field of corneal tissue engineering has made many strides in recent years. The challenges of engineering a biocompatible, mechanically stable, and optically transparent tissue are significant. To overcome these challenges, researchers have adopted two basic approaches: cell-based strategies for manipulating cells to create their own extracellular matrix, and scaffold-based strategies for providing strong and transparent matrices upon which to grow cells. Both strategies have met with some degree of success. In addition, recent advances have been made in innervating a tissueengineered construct. Future work will need to focus on further improving mechanical stability of engineered constructs as well as improving the host response to implantation.

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Keratoprostheses: Advancing toward a true artificial cornea

Cited by 141 publications

References 69 publications

Corneal replacement using a synthetic hydrogel cornea, AlphaCor™: device, preliminary outcomes and complications

Corneal replacement using a synthetic hydrogel cornea, AlphaCor™: device, preliminary outcomes and complications

AlphaCor artificial cornea: clinical outcome

The Development of a Tissue-Engineered Cornea: Biomaterials and Culture Methods

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