Keratoprosthesis

Jun, Jason; Siracuse-Lee, Donna; Daly, Mary K.; Dohlman, Claes H.

doi:10.1007/978-3-540-85544-6_10

Cited by 1 publication

(9 citation statements)

References 43 publications

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“…PHEMA is used in contact lenses because of its favorable tear film wettability . Reports concerning the ocular response to PHEMA and PMMA and mechanical data (Fig. ) suggest that the novel KPro may sustain intraocular pressure and resist mechanical rupture.…”

Section: Discussionmentioning

confidence: 96%

“…An artificial cornea or keratoprosthesis can restore vision when cornea transplantation is not a viable option . Approximately 8 million people worldwide are blind due to corneal disease.…”

Section: Introductionmentioning

confidence: 99%

“…However, upon failure, regrafting may be necessary, and only 20% of regrafts are viable after 5 years. Unsuccessful corneal grafts and inadequate donor cornea supplies drive the demand for safe and effective keratoprostheses . However, currently available full penetrating keratoprostheses (KPros) inadequately address one or more of the following vital parameters: long term host integration, mass transport, tissue epithelialization, or innervation.…”

Section: Introductionmentioning

confidence: 99%

“…However, currently available full penetrating keratoprostheses (KPros) inadequately address one or more of the following vital parameters: long term host integration, mass transport, tissue epithelialization, or innervation. An inadequate KPro design can result in extrusion, necrosis, increased intraocular pressure, or infection …”

Section: Introductionmentioning

confidence: 99%

“…Vascularization and corneal cell ingrowth were observed in the device skirt . Similar to Guo's KPro, our current study presents a PHEMA‐PMMA KPro that incorporates the core‐skirt model, in which the core (or central transparent region) is designed to facilitate vision while the porous skirt (outer rim) should permit tissue ingrowth. Unlike Guo's KPro, our KPro design applies an alternate fabrication technique by combining PHEMA and PMMA and using sodium chloride (NaCl) as a pore‐generating agent (i.e., porogen) to create a network of pores in the skirt.…”

Section: Introductionmentioning

confidence: 99%

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Engineering copolymeric artificial cornea with salt porogen

Zellander

Wardlow

Djalilian

et al. 2013

J Biomedical Materials Res

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Artificial corneas or keratoprostheses (KPros) are designed to replace diseased or damaged cornea. Although many synthetic KPros have been developed, current products are often inappropriate or inadequate for long term use due to ineffective host integration. This study presents an alternative approach of engineering a KPro that comprises a combination of poly (2-hydroxyethyl methacrylate) (PHEMA), poly (methyl methacrylate) (PMMA), and sodium chloride (NaCl) as porogen. Based on the core-skirt model for KPro, the porous outer portion of artificial cornea (skirt) was engineered by combining NaCl with HEMA and MMA monomers to promote tissue ingrowth from the host. The central optic (core) was designed to provide >85% light transmission in the visible wavelength range and securely attached to the skirt. Mechanical tensile data indicated that our KPro (referred to as salt porogen KPro) is mechanically stable to maintain its structure in the ocular environment and during implantation. Using human corneal fibroblasts (HCFs), we demonstrate that the cells grew into the pores of the skirt and proliferated, suggesting biointegration is adequately achieved. This novel PHEMA-PMMA copolymeric salt porogen KPro may offer a cornea replacement option that leads to minimal risk of corneal melting by permitting sufficient tissue ingrowth and mass transport.

show abstract

Section: Discussionmentioning

confidence: 96%

“…An artificial cornea or keratoprosthesis can restore vision when cornea transplantation is not a viable option . Approximately 8 million people worldwide are blind due to corneal disease.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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