Keratosis Palmaris et Plantaris

Focal palmoplantar and gingival keratosis: A distinct palmoplantar ectodermal dysplasia with epidermolytic alterations but lack of mutations in known keratins

“…The adult patients additionally demonstrated slight periungeal keratoses at several toe-and fingernails, but there were no subungeal keratoses, nail changes, hyperhidrosis, or follicular hyperkeratosis as described in some other cases of FPGK. [1][2][3][4] The fourth patient was a 6-year-old girl who showed slight and painful hyperkeratosis at the weight-bearing plantar skin, but no lesions of the oral mucosa at first examination. The definite diagnosis of FPGK could only be made 3 years later, after the patient developed some circumscribed leukoplakic lesions of the attached gingiva.…”

“…In addition to these findings, some of the affected patients were also reported to present nail changes, peri-and subungeal keratoses, follicular hyperkeratosis, hyperhidrosis, and oral keratotic lesions at other points of mechanical pressure. [1][2][3][4] Since the first description of focal palmoplantar and gingival keratosis (FPGK) in 1964, 2 only a few cases have been reported, including some families affected by the disease in several consecutive generations pointing to autosomal dominant inheritance. 1,[3][4][5][6] The clinical features of the disease remain to be defined in more detail.…”

X‐Linked Dominant Inheritance in Palmoplantar Keratoderma with Leukokeratosis: A Study of the Pedigree of Two Cases

“…Though the keratotic lesions of the soles were painful while walking, the absence of fissure in them could be due to the presence of hyperhiderosis. None of these siblings had any nail changes though dystrophic changes had been observed (10, 12). Absence of involvement of nail, hair and periorificial area and constriction bands ruled out pachyonychia congenita and Olmsted syndrome respectively.…”

“…PPK in combination with carcinoma oesophagus and oral leukokeratosis has been reported in the past (8–9). The combination of oral leukokeratosis without any other systemic changes has also been seen with PPK (10–13). Squamous cell carcinoma may develop in the tylotic skin either in association with carcinoma of oesophagus or without it (5, 14).…”

Pityriasis Rubra Pilaris in Korea

“…In the literature, we often found th a t keratoderm a palm aris et plantaris, hyperkeratosis palm aris et plantaris, and tylosis were simi lar to PK P [1,2,4,5,6]. Psoriasis, callosities, arsenical keratosis, tinea pedis, phrynoderm a, and even yaws could easily be confused in m any patients.…”