Keratosis pilaris caused by dupilumab for the treatment of bronchial asthma

Abstract

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An uncommon case of lichen spinulosus induced by dupilumab in a patient treated for bronchial asthma

“…7 To date, KP occurrence has been reported in 2 asthma patients under treatment with dupilumab. 8 It has been hypothesized that dupilumab induces a transition of hair follicles from telogen phase to anagen phase, by increasing regulatory T lymphocyte activity. 8 Subsequently, given the insufficient ability of hairs to penetrate the stratum corneum, the hair remains in the follicular infundibulum leading to the development of KP.…”

“…8 It has been hypothesized that dupilumab induces a transition of hair follicles from telogen phase to anagen phase, by increasing regulatory T lymphocyte activity. 8 Subsequently, given the insufficient ability of hairs to penetrate the stratum corneum, the hair remains in the follicular infundibulum leading to the development of KP. 8 Furthermore, LS has been described in HIV patients and has been also associated to overexpression of immunological response to hair follicular microorganisms (i.e., Malassetia spp.…”

“…8 Subsequently, given the insufficient ability of hairs to penetrate the stratum corneum, the hair remains in the follicular infundibulum leading to the development of KP. 8 Furthermore, LS has been described in HIV patients and has been also associated to overexpression of immunological response to hair follicular microorganisms (i.e., Malassetia spp. ); in both these conditions an overexpression of Th17 mediate response has been reported.…”