A methodology for assessing the inputs-outputs association for time-dependent predictive models subjected to safety
objectives is investigated. Firstly, new dependency models for sampling random values of uncertain inputs that comply
with the safety objectives are provided by making use of the desirability measures. Secondly, combining predictive risk
models with such dependency models leads to the development of new kernel-based statistical tests of independence
between the (safe) dynamic outputs and inputs. The associated test statistics are then normalized so as to introduce the first-order and total sensitivity indices that account for the desirability measures. Such indices rely on time-dependent sensitivity functionals (SFs) and kernel methods, which allow for treating nonstationary SFs as well as SFs having skewed or heavy-tailed distributions. Our approach is also well-suited for dynamic hazard models with prescribed copulas of inputs.