Kernel learning enables fluorescence microscopic image deconvolution with enhanced performance and speed
Shenghua Cheng,
Qiqi Lu,
Hua Ye
et al.
Abstract:The contrast and resolution of fluorescence microscopic images can be effectively improved by classic iterative Richardson-Lucy Deconvolution (RLD) algorithm, but this method is computationally expensive, particularly for three-dimensional data. Variants of RLD with manually designed unmatched backward projector can greatly accelerate deconvolution, however, they require careful parameter optimization to avoid introducing artifacts. Here, we develop Kernel Learning Deconvolution (KLD), which automatically lear… Show more
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