Ketamine anaesthesia following premedication of rabbits with vitamin C

Elsa, A. T.; Ubandawaki, Stephen

doi:10.4142/jvs.2005.6.3.239

Cited by 7 publications

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“…Elas and Najafpour have also reported that vitamin C administration prior to ketamine treatment could be used to increase the duration of anesthesia in rabbits. 29,30 Oral melatonin can enhance the anesthetic effect of thiopental and ketamine in rats. 31 Egwu has stated that vitamin C prolonged the sleeping time of rabbits after xylazine administration.…”

Section: Discussionmentioning

confidence: 99%

Intraoperative Vitamin C Reduces the Dosage of Propofol in Patients Undergoing Total Knee Replacement

Yang

Feng

Zhang

et al. 2021

JPR

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Purpose: Propofol is commonly used as an intravenous anesthetic in surgical patients. However, its usage is associated with adverse effects. Auxiliary medication can reduce the dose of intravenous anesthetics. Hence, we investigated whether vitamin C could lower propofol dosage in elderly patients undergoing total knee replacement surgery. Patients and Methods: The trial was carried out in PLA General Hospital in Beijing, China. We enrolled patients aged ≥50 years who were undergoing unilateral total knee arthroplasty with total intravenous anesthesia combined with lumbar sciatic nerve block. The patients were randomly assigned to either the vitamin C (Vc) group (0.067 g/kg) or the control group (an equivalent dose of normal saline). Nerve block was done for all the patients before the general anesthesia. The same depth of anesthesia was maintained during the operation. We compared the propofol dosage and adverse events (eg hypotension) during anesthesia between the two groups. This study was registered with the Chinese Clinical Trial Registry, www.chictr.org.cn, number ChiCTR-TRC-16010112. Results: There were significant differences in the total infusion dose (Vc group: 704.3 ± 188.6 mg; control group: 888.6 ± 232.7 mg; p = 0.016) and the average maintenance dose of propofol (Vc group: 5.8 ± 1.0 mg/kg/h; control group: 6.9 ± 1.6 mg/kg/h; p = 0.013). But there were no significant differences in the induction dose of propofol (control group: 90 mg, range 80-115 mg; Vc group: 100 mg, range 90-110 mg, p = 0.379) between the Vc and control groups. Furthermore, there were no significant differences in the hemodynamics and the incidence of intraoperative hypotension. Conclusion: Vitamin C can reduce the dosage of propofol in patients undergoing total knee replacement.

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Section: Discussionmentioning

confidence: 99%

Intraoperative Vitamin C Reduces the Dosage of Propofol in Patients Undergoing Total Knee Replacement

Yang

Feng

Zhang

et al. 2021

JPR

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“…Its deficiency has been reported to cause impairment of CNS function (Laurence et al 1997). Previous studies reported that the use of vitamin C for premedication could accelerate the onset of anesthesia and increase the time of surgical anesthesia (Elsa and Ubandawaki 2005;Ito et al 2014). Elsa and Ubandawaki (2005) administered different doses of vitamin C to rabbits before ketamine anesthesia.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies reported that the use of vitamin C for premedication could accelerate the onset of anesthesia and increase the time of surgical anesthesia (Elsa and Ubandawaki 2005;Ito et al 2014). Elsa and Ubandawaki (2005) administered different doses of vitamin C to rabbits before ketamine anesthesia. They found a statistically significant increase in total anesthesia time with an increasing dose of vitamin C as CNS functions were disrupted.…”

Section: Discussionmentioning

confidence: 99%

“…No complications occurred while anesthetizing the rabbits. Some studies (Elsa and Ubandawaki 2005;Yanmaz et al 2016) showed that vitamin C had a depressive effect on the CNS and reduced the heart rate. In the present study, although the decrease in heart rate was statistically significant in both groups, the decrease in the MK group was greater than that in the AAMK group however, no significant difference in heart rate was found between the groups (P > 0.05).…”

Section: Discussionmentioning

confidence: 99%

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Yeni Zelanda Beyaz Tavşanlarında Medetomidin – Ketamin Anestezisi Öncesi Preanestezik Olarak Vitamin C Kullanılması

Yaygingül¹

2018

Kocatepe Veterinary Journal

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This study aimed to investigate the effects of premedication with ascorbic acid (vitamin C) on physiologic parameters before medetomidine-ketamine anesthesia in New Zealand white rabbits. A total of 14 rabbits of both sexes, 1-4 months of age and 2-4 kg in body weight, were used in this study. The rabbits were randomly assigned one of two groups: medetomidine-ketamine (MK) or ascorbic acid-medetomidine-ketamine (AAMK). The rabbits in the MK group were given 0.25 mg/kg of medetomidine and 15 mg/kg of ketamine intramuscularly. The rabbits in the AAMK group were given 60 mg/kg of vitamin C intramuscularly 20 min prior to the same dose of medetomidine-ketamine anesthesia. The onset of anesthesia, time of surgical anesthesia, and total anesthesia time in the two groups was recorded. Heart rate, respiratory rate, and body temperature were also recorded at 0, 5, 10, 15, 20, 25, 30, 45 and 60 minutes during anesthesia. Physiologic parameters were not statistically different between the two groups. Pretreatment with vitamin C prior to medetomidine-ketamine anesthesia decreased the duration of onset of anesthesia. As a result, it was concluded that vitamin C can be used prior to anesthesia to accelerate the effect of medetomidine-ketamine in rabbits. ÖZBu çalışmada, beyaz Yeni Zelanda tavşanlarında medetomidin -ketamin anestezisi öncesi preanestezik olarak uygulanan askorbik asitin (vitamin C=vit ) fizyolojik parametreler üzerine etkisinin araştırılması amaçlanmıştır. Her iki cinsiyette 1-4 aylık ve 2-4 kg vücut ağırlığında sahip toplam 14 tavşan bu çalışma için kullanıldı. Tavşanlar rastgele iki gruba ayrıldı; medetomidin -ketamin (MK) ya da askorbik asit -medetomidin -ketamin (AAMK). MK grubundaki tavşanlara 0.25 mg/kg medetomidin ve 15 mg/kg ketamin intramuscular olarak uygulandı. AAMK grubundaki tavşanlara aynı dozdaki medetomidin-ketamin anestezisinden 20 dk önce 60 mg/kg oranında kas içi C vitamini verildi. İki grupta anestezi başlangıç zamanı, cerrahi anestezi süresi ve total anestezi zamanı kaydedildi. Anestezi sırasında kalp oranı, solunum oranı ve vücut sıcaklığı 0, 5, 10, 15, 20, 25, 30, 45 ve 60 dakikalarda kaydedildi. Fizyolojik parametreler açısından her iki grupta istatiksel olarak fark belirlenemedi. Sonuç olarak, tavşanlarda medetomidin -ketamin anestezisi öncesi C vitaminin kullanılması anestezi giriş süresini kısalttığı görülmüştür.

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“…Some researchers maintain anaesthesia in rabbits using a continuous rate infusion of either ketamine and fentanyl or propofol, along with isoflurane (Sakamoto et al, 2003). Early work with vitamin C suggests it may also potentiate ketamine anaesthesia in rabbits (Elsa and Ubandawaki, 2005).…”

Section: Injectable Agentsmentioning

confidence: 99%

Rabbit anaesthesia

Longley

2008

Anaesthesia of Exotic Pets

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Ketamine anaesthesia following premedication of rabbits with vitamin C

Cited by 7 publications

References 0 publications

Intraoperative Vitamin C Reduces the Dosage of Propofol in Patients Undergoing Total Knee Replacement

Intraoperative Vitamin C Reduces the Dosage of Propofol in Patients Undergoing Total Knee Replacement

Yeni Zelanda Beyaz Tavşanlarında Medetomidin – Ketamin Anestezisi Öncesi Preanestezik Olarak Vitamin C Kullanılması

Rabbit anaesthesia

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