Ketamine anaesthesia has no effect on striatal dopamine metabolism in rats

Koshikawa, Noriaki; Tomiyama, Katsunori; Omiya, Kiyomi; Kobayashi, Masafumi

doi:10.1016/0006-8993(88)90954-7

Cited by 35 publications

(10 citation statements)

References 7 publications

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“…No data in the literature support this hypothesis. In contrast, a number of studies have consistently shown that halothane increases striatal DA levels (Ford and Marsden 1986;Savaki et al 1986;Spampinato et al 1986;Osborne et al 1990;Stahle et al 1990;Miyano et al 1993;Mantz et al 1994;Shiraishi et al 1997;Keita et al 1999) whereas ketamine has no effect (Ylitalo et al 1976;Koshikawa et al 1988;Lannes et al 1991;Micheletti et al 1992;Onoe et al 1994;Mantz et al 1994;Irifune et al 1997;Tsukada et al 2000).…”

Section: Discussionmentioning

confidence: 93%

“…One of the most commonly used anesthetic, ketamine, is a noncompetitive N-methyl-D-aspartate antagonist that induces psychotic symptoms in humans. This effect is thought to be due to a facilitation of DA neurotransmission although several studies indicate that ketamine has no significant effect on striatal DA levels (Ylitalo et al 1976;Koshikawa et al 1988;Lannes et al 1991;Micheletti et al 1992;Onoe et al 1994;Mantz et al 1994;Irifune et al 1997;Tsukada et al 2000). Volatile anesthetics such as halothane have been consistently shown to release striatal DA (Ford and Marsden 1986;Savaki et al 1986;Spampinato et al 1986;Osborne et al 1990;Stahle et al 1990;Miyano et al 1993;Mantz et al 1994;Shiraishi et al 1997;Keita et al 1999).…”

mentioning

confidence: 99%

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Effects of Amphetamine and Evoked Dopamine Release on [11C]raclopride Binding in Anesthetized Cats

Ginovart

Hassoun

Cavorsin

et al. 2002

Neuropsychopharmacology

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Section: Discussionmentioning

confidence: 93%

mentioning

confidence: 99%

Effects of Amphetamine and Evoked Dopamine Release on [11C]raclopride Binding in Anesthetized Cats

Ginovart

Hassoun

Cavorsin

et al. 2002

Neuropsychopharmacology

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“…The average values (n ϭ 4 for each points) for Bound and Free were used in a Scatchard analysis in which the ratios Bound/Free were plotted against Bound. Koshikawa et al, 1988;Onoe et al, 1994;Tsukada et al, 2000a) dopamine concentration in the striatum. It is of interest that MK-801 significantly increased stereotypic behavior but did not affect the striatal dopamine concentration (Weihmuller et al, 1991).…”

Section: Discussionmentioning

confidence: 98%

Cholinergic Neuronal Modulation Alters Dopamine D₂Receptor Availability In Vivo by Regulating Receptor Affinity Induced by Facilitated Synaptic Dopamine Turnover: Positron Emission Tomography Studies with Microdialysis in the Conscious Monkey Brain

et al. 2000

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To evaluate the cholinergic and dopaminergic neuronal interaction in the striatum, the effects of scopolamine, a muscarinic cholinergic antagonist, on the striatal dopaminergic system were evaluated multi-parametrically in the conscious monkey brain using high-resolution positron emission tomography in combination with microdialysis. L-3,4-Dihydroxyphenylalanine (L-[␤-11 C]DOPA) and 2␤-carbomethoxy-3␤-(4-fluorophenyl)-tropane ([␤-11 C]CFT) were used to measure dopamine synthesis rate and dopamine transporter (DAT) availability, respectively. For assessment of dopamine D 2 receptor binding in vivo, [ 11 C]raclopride was applied because this labeled compound, which has relatively low affinity to dopamine D 2 receptors, was hypothesized to be sensitive to the striatal synaptic dopamine concentration. Systemic administration of scopolamine at doses of 10 and 100 g/kg dose-dependently increased both dopamine synthesis and DAT availability as measured by L-[␤-11 C]DOPA and [␤-11 C]CFT, respectively. Scopolamine decreased the binding of [ 11 C]raclopride in a dose-dependent manner. Scopolamine induced no significant changes in dopamine concentration in the striatal extracellular fluid (ECF) as determined by microdialysis. However, scopolamine dose-dependently facilitated the striatal ECF dopamine induced by the DAT inhibitor GBR12909 at a dose of 0.5 mg/kg. Scatchard plot analysis in vivo of [ 11 C]raclopride revealed that scopolamine reduced the apparent affinity of dopamine D 2 receptors. These results suggested that the inhibition of muscarinic cholinergic neuronal activity modulates dopamine turnover in the striatum by simultaneous enhancement of the dynamics of dopamine synthesis and DAT availability, resulting in no significant changes in apparent "static" ECF dopamine level but showing a decrease in [ 11 C]raclopride binding in vivo attributable to the reduction of affinity of dopamine D 2 receptors.

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“…It may be that the CBF increase is too minor to produce a detectable effect, or that it is counteracted by a local action of this substance on the extracellular DA. The effect of ketamine on the extracellular DA is a matter of some controversy [42,43,44,45], but it is well documented that DA release is under the control of NMDA receptors, on which ketamine exerts an antagonistic action. Thus the absence of an effect of ketamine on BP raclo in the striatum could be due to both a slight increase in the CBF, favouring radioligand binding, and a simultaneous increase in the extracellular DA with which it is competing, as has previously been suggested [46,47].…”

Section: Discussionmentioning

confidence: 99%

PET study of the [ 11 C]raclopride binding in the striatum of the awake cat: effects of anaesthetics and role of cerebral blood flow

Hassoun

Cavorsin

Ginovart

et al. 2003

European Journal of Nuclear Medicine and Molecular Imaging

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Cats were trained to stay in a containment box, without developing any signs of behavioural stress, while their head was maintained in a position that allowed positron emission tomography (PET) experiments to be performed. The binding potential for [(11)C]raclopride (BP(raclo)), a radioligand with good specificity for dopamine (DA) receptors of the D(2) type, was measured in the striatum and in three experimental situations: awake, anaesthetised with ketamine (50 mg kg(-1) h(-1); i.m.) and anaesthetised with halothane (1.5%). Non-specific binding was evaluated in the cerebellum. In the striatum of both sides, the BP(raclo) was unmodified by ketamine anaesthesia when compared with awake animals. In contrast, a large increase in BP(raclo) was observed under halothane anaesthesia. The non-specific binding of [(11)C]raclopride, evaluated in the cerebellum, was also unchanged under ketamine anaesthesia but greatly increased under halothane anaesthesia. To evaluate whether changes in the cerebral blood flow (CBF) resulting from the different experimental situations could be at the root of these discrepancies, injections of [(15)O]H(2)O were performed; measurements revealed a drastically increased CBF under halothane anaesthesia and a slight enhancement under ketamine anaesthesia, when compared with the waking state. These results are the first to be obtained on this topic in awake cats, and show that the BP(raclo) is greatly dependent on alterations in the CBF.

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Ketamine anaesthesia has no effect on striatal dopamine metabolism in rats

Cited by 35 publications

References 7 publications

Effects of Amphetamine and Evoked Dopamine Release on [11C]raclopride Binding in Anesthetized Cats

Effects of Amphetamine and Evoked Dopamine Release on [11C]raclopride Binding in Anesthetized Cats

Cholinergic Neuronal Modulation Alters Dopamine D₂Receptor Availability In Vivo by Regulating Receptor Affinity Induced by Facilitated Synaptic Dopamine Turnover: Positron Emission Tomography Studies with Microdialysis in the Conscious Monkey Brain

PET study of the [ 11 C]raclopride binding in the striatum of the awake cat: effects of anaesthetics and role of cerebral blood flow

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Ketamine anaesthesia has no effect on striatal dopamine metabolism in rats

Cited by 35 publications

References 7 publications

Effects of Amphetamine and Evoked Dopamine Release on [11C]raclopride Binding in Anesthetized Cats

Effects of Amphetamine and Evoked Dopamine Release on [11C]raclopride Binding in Anesthetized Cats

Cholinergic Neuronal Modulation Alters Dopamine D2Receptor Availability In Vivo by Regulating Receptor Affinity Induced by Facilitated Synaptic Dopamine Turnover: Positron Emission Tomography Studies with Microdialysis in the Conscious Monkey Brain

PET study of the [ 11 C]raclopride binding in the striatum of the awake cat: effects of anaesthetics and role of cerebral blood flow

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Resources

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Cholinergic Neuronal Modulation Alters Dopamine D₂Receptor Availability In Vivo by Regulating Receptor Affinity Induced by Facilitated Synaptic Dopamine Turnover: Positron Emission Tomography Studies with Microdialysis in the Conscious Monkey Brain